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Crystals
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Nano-Biotechnology: Nanomaterials for Targeted Delivery
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Nano-Biotechnology: Nanomaterials for Targeted Delivery

A special issue of Crystals (ISSN 2073-4352).

Deadline for manuscript submissions: closed (25 February 2022) | Viewed by 9076

Special Issue Editors

Dr. Fahimeh Charbgoo

E-Mail Website
Guest Editor
DWI - Leibniz-Institute for Interactive Materials, Forckenbeckstraße 50, 52074 Aachen, Germany
Interests: nanomedicine; DNA nanocarriers; aptamer; remote control; gene activation; biomimics
Dr. Ionut Tudorancea

E-Mail Website
Guest Editor
1. 1st Medical Department, “Grigore T. Popa” University of Medicine and Pharmacy, Iași, Romania
2. Cardiology Department, Emergency Clinical County Hospital, Iasi, Romania
Interests: cardiac arrhythmias; pacemakers; heart rate variability; electrocardiography; cardiovascular pharmacology; experimental medicine; blood pressure; heart failure; hypertension; acute coronary syndromes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We now have potential platforms for improving lives by introducing non-aggressive methods of therapy and reducing the side effects of medical agents. This has already begun through the targeted delivery of therapeutics and remote control of bioprocesses. Nanobiotechnology can develop materials with unique properties for this purpose such as a high level of penetration, high capacity for loading cargo and multi-functionality. There are some nanomaterials that are approved by the Food, Drug Administration (FDA) and European Medicines Agency (EMA), which are mostly biomimicking nanocarriers such as lipid and peptide nanoparticles but also some metal nanoparticles such as SPOIN, and nanocrystals such as paliperidone palmitate and dantrolene sodium have FDA and EMA approval. Researchers have made substantial efforts to produce systems for delivering therapeutics at specific sites at the desired times with controlled doses using nanomaterials. However, there have been few clinical applications, and this important issue should be addressed in our future studies. The change in the identity of nanocarriers should also be researched; this results in a change in their fate in the body due to corona formation on the nanoparticle’s surface. To discuss this and many other open questions, introduce the latest research and develop new ideas and directions, we will provide a Special Issue on Nanomaterials and Targeted delivery in Crystals, an open access journal.

This Special Issue is collecting research articles and review papers on “Nanobiotechnology: Nanomaterials for Targeted Delivery”.

Dr. Fahimeh Charbgoo
Dr. Ionut Tudorancea
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Crystals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nanofabrication
  • Drug targeting
  • Nanocarriers
  • Remote control
  • Trigger-responsive system

Published Papers (4 papers)

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Review

15 pages, 309 KiB  
Review
Nanocarrier-Based Management of Venous and Arterial Thrombosis
by Mihai Ștefan Cristian Haba, Dragomir N. Șerban, Ionela Lăcrămioara Șerban, Ivona Maria Tudorancea, Raluca Maria Haba, Minela Aida Mărănducă, Daniela Maria Tănase, Radu Iliescu and Ionuț Tudorancea
Crystals 2022, 12(4), 450; https://doi.org/10.3390/cryst12040450 - 23 Mar 2022
Cited by 1 | Viewed by 1939
Abstract
Cardiovascular diseases represent the leading cause of mortality worldwide, with recent epidemiological studies revealing an increasing trend of prevalence and incidence globally. Among cardiovascular disorders, both arterial and venous thrombosis and particularly their acute life-threating complications such as ischemic stroke, acute myocardial infarction, [...] Read more.
Cardiovascular diseases represent the leading cause of mortality worldwide, with recent epidemiological studies revealing an increasing trend of prevalence and incidence globally. Among cardiovascular disorders, both arterial and venous thrombosis and particularly their acute life-threating complications such as ischemic stroke, acute myocardial infarction, deep venous thrombosis and pulmonary embolism are responsible for more than 25% of all deaths worldwide. The modern approach following progresses in anticoagulant, thrombolytic and antiaggregant therapies has significantly improved the prognoses of these conditions in the last past decades. However, several challenges still remain such as achieving the optimal drug concentration at the injured site, reducing the shortcomings of drug resistance and the incidence of life-threatening hemorrhages. Nanomedicine is a well-known field of medicine in which atomic and molecular structures ranging between 0.1–100 nm are used in various domains due to their specific mechanical, electrical, thermal and magnetic properties. Recent experimental and clinical evidence have shown that nanotechnology could be a safe, effective and an appealing approach for various non-cardiovascular and cardiovascular diseases such as thromboembolic conditions. In this review, we have described the most promising nanotechnology-based approaches not only for the diagnosis, but also for the treatment of vascular thrombotic diseases. Full article
(This article belongs to the Special Issue Nano-Biotechnology: Nanomaterials for Targeted Delivery)
11 pages, 3614 KiB  
Review
Collagen-Binding Nanoparticles: A Scoping Review of Methods and Outcomes
by Cristian-Ene Roată, Ștefan Iacob, Ștefan Morărașu, Cristian Livadaru, Ionuț Tudorancea, Sorinel Luncă and Mihail-Gabriel Dimofte
Crystals 2021, 11(11), 1396; https://doi.org/10.3390/cryst11111396 - 15 Nov 2021
Cited by 6 | Viewed by 1796
Abstract
(1) Background: Collagen is the main component of the connective tissue, playing an important role in the histological architecture and function of living organisms. Targeted therapy and improved imaging diagnosis can be obtained through collagen-binding nanoparticles that concentrate in the extracellular matrix. (2) [...] Read more.
(1) Background: Collagen is the main component of the connective tissue, playing an important role in the histological architecture and function of living organisms. Targeted therapy and improved imaging diagnosis can be obtained through collagen-binding nanoparticles that concentrate in the extracellular matrix. (2) Methods: We performed a scoping review of studies that analyzed the binding capacity of collagen-targeting nanoparticles. The search algorithm and inclusion criteria were based on PRISMA and ARRIVE guidelines. (3) Results: Fourteen studies matched all the inclusion criteria. All studies analyzed the distribution of nanoparticles in the collagen matrix, either by using collagen-targeting nanoparticles or by using unmodified ones. Most studies used collagen-binding nanoparticles for vascular research to target sites of endothelial injury, atherosclerotic plaques, or myocardial infarction. Two studies targeted the exposed collagen in models of liver fibrosis. (4) Conclusions: Our review summarizes the current literature on the methods and outcomes of using nanoparticles to target collagen. The studies reveal that there is high applicability for collagen-binding nanoparticles in cardiac or hepatic pathology and they could prove useful for targeted therapy of neoplastic lesions, which show an abundance of stromal collagen. Full article
(This article belongs to the Special Issue Nano-Biotechnology: Nanomaterials for Targeted Delivery)
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16 pages, 324 KiB  
Review
Nanomaterial-Based Drug Targeted Therapy for Cardiovascular Diseases: Ischemic Heart Failure and Atherosclerosis
by Mihai Ștefan Cristian Haba, Dragomir N. Șerban, Lăcrămioara Șerban, Ivona Maria Tudorancea, Raluca Maria Haba, Ovidiu Mitu, Radu Iliescu and Ionuț Tudorancea
Crystals 2021, 11(10), 1172; https://doi.org/10.3390/cryst11101172 - 27 Sep 2021
Cited by 5 | Viewed by 2480
Abstract
Cardiovascular diseases (CVDs) represent the most important epidemic of our century, with more than 37 million patients globally. Furthermore, CVDs are associated with high morbidity and mortality, and also increased hospitalization rates and poor quality of life. Out of the plethora of conditions [...] Read more.
Cardiovascular diseases (CVDs) represent the most important epidemic of our century, with more than 37 million patients globally. Furthermore, CVDs are associated with high morbidity and mortality, and also increased hospitalization rates and poor quality of life. Out of the plethora of conditions that can lead to CVDs, atherosclerosis and ischemic heart disease are responsible for more than 2/3 of the cases that end in severe heart failure and finally death. Current therapy strategies for CVDs focus mostly on symptomatic benefits and have a moderate impact on the underlying physiopathological mechanisms. Modern therapies try to approach different physiopathological pathways such as reduction of inflammation, macrophage regulation, inhibition of apoptosis, stem-cell differentiation and cellular regeneration. Recent technological advances make possible the development of several nanoparticles used not only for the diagnosis of cardiovascular diseases, but also for targeted drug delivery. Due to their high specificity, nanocarriers can deliver molecules with poor pharmacokinetics and dynamics such as: peptides, proteins, polynucleotides, genes and even stem cells. In this review we focused on the applications of nanoparticles in the diagnosis and treatment of ischemic heart failure and atherosclerosis. Full article
(This article belongs to the Special Issue Nano-Biotechnology: Nanomaterials for Targeted Delivery)
12 pages, 889 KiB  
Review
Targeted Chemotherapy Delivery via Gold Nanoparticles: A Scoping Review of In Vivo Studies
by Ștefan Morărașu, Ștefan Iacob, Ionuț Tudorancea, Sorinel Luncă and Mihail-Gabriel Dimofte
Crystals 2021, 11(10), 1169; https://doi.org/10.3390/cryst11101169 - 26 Sep 2021
Cited by 1 | Viewed by 1940
Abstract
In the field of oncology, a lot of improvements in nanotechnology creates support for better diagnosis and therapeutic opportunities, and due to their physical and chemical properties, gold nanoparticles are highly applicable. We performed a literature review on the studies engaging the usage [...] Read more.
In the field of oncology, a lot of improvements in nanotechnology creates support for better diagnosis and therapeutic opportunities, and due to their physical and chemical properties, gold nanoparticles are highly applicable. We performed a literature review on the studies engaging the usage of gold nanoparticles on murine models with a focus on the type of the carrier, the chemotherapy drug, the target tumoral tissue and outcomes. We identified fifteen studies that fulfilled our search criteria, in which we analyzed the synthesis methods, the most used chemotherapy conjugates of gold nanoparticles in experimental cancer treatment, as well as the improved impact on tumor size and system toxicity. Due to their intrinsic traits, we conclude that chemotherapy conjugates of gold nanoparticles are promising in experimental cancer treatment and may prove to be a safer and improved therapy option than current alternatives. Full article
(This article belongs to the Special Issue Nano-Biotechnology: Nanomaterials for Targeted Delivery)
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