Targeted Chemotherapy Delivery via Gold Nanoparticles: A Scoping Review of In Vivo Studies
Abstract
:1. Introduction
2. Materials and Methods
2.1. Literature Search and Study Selection
2.2. Data Analysis
2.3. Quality Assessment
3. Results
3.1. Literature Review and Design of Eligible Studies
3.2. Synthesis and Delivery of AuNPs-Chemotherapy Conjugates (AuNPCC)
3.3. Selection of Chemotherapeutics
3.4. In Vivo Antitumoral Activity of AuNPCC
3.5. Systemic Biodistribution of AuNPCC
4. Discussion
4.1. Literature Overview
4.2. Limitations of the Study
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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First Author | Novelty |
---|---|
Bao [17] | Using hybrid liposome with AuNPs to investigate the therapeutic outcome |
Davidi [18] | AuNPs acting as drug carrier, radiosensitizer and contrast agent |
Hale [19] | Using 2nm AuNPs conjugated with maytansine analogue for the treatment of hepatocellular carcinoma |
Hung [20] | Significant inhibition of mutated KRAS gene in colorectal cancer cells using AuNPs with Doxurubicin (DXR) |
Khademi [21] | Efficient usage of Chitosan coated-AuNPs with aptamers and DXR on cancer cell lines |
Li [22] | Reducing toxicity and improving tumoral tissue destruction with heated-hallow AuNPs with thermosensitive liposomal DXR carriers |
Liu [23] | Using chemo-photothermal synergic cancer therapy through AuNPs-Paclitaxel (PTX) and a hydrogel with gold nanorods with phototermal properties |
Mirrahimi [24] | Using a novel nanocomplex comprising alginate nanogel co-loaded with Cisplatin (CIS) and AuNPs for chemo-phothermal therapy |
Nair [25] | Enhanced anti-tumor effect and diminished system toxicity through chemo-photothermal therapy with hallow AuNPs and docetaxel |
Peng [26] | The use of renal-clearable AuNPs with DXR |
Ruttala [27] | Usage of a nanoplatform created from AuNPs-Lonidamine-Albumin-Aptamer for targeted tumoral destruction |
Xing [28] | Using AuNPs-DXRcomplex co-encapsulated withing a liposome for targeted chemo-photothermal therapy |
Xiong [29] | Prevention of tumoral CIS-induced chemoresistence throught AuNPs pretreatment |
Zabielska-Koczywas [30] | The biodistribution and the effect of Glutathione-stabilized AuNPs with DXR in Feline Injection Site Sarcoma |
Zhou [31] | The diagnostics and therapeutic effect of fluorescent gold nanoclusters conjugated with CIS and folic acid |
First Author | Year of Publication | Type of AuNPCC | Chemotherapeutic | Type of Tumor | Route of Administration |
---|---|---|---|---|---|
Bao [17] | 2014 | loaded in liposomes | PTX | Hepatic carcinoma | intravascular |
Davidi [18] | 2017 | simple conjugates | CIS | A431 (squamous carcinoma) | intravascular |
Hale [19] | 2018 | maytansine conjugated AuNPs (Brust–Schiffrin synthesis) | Maytansine | HCC | intravascular |
Hung [20] | 2019 | biopolymer composite | DXR | DLD-1 (colorectal adenocarcinoma) | intraperitoneal |
Khademi [21] | 2020 | biopolymer composite | DXR | 4T1 (breast carcinoma) | intravascular |
Li [22] | 2018 | loaded in liposomes | DXR | MCF-7 (breast carcinoma) | intravascular |
Liu [23] | 2019 | biopolymer composite | PTX | 4T1 (breast carcinoma) | subcutaneous |
Mirrahimi [24] | 2019 | nanogel construct | CIS | CT26 (colon adenocarcinoma) | intraperitoneal |
Nair [25] | 2020 | folate-calix construct | DXR | HeLa (cervical cancer); A549 (lung adenocarcinoma) | intraperitoneal |
Peng [26] | 2019 | simple conjugates | DXR | 4T1 (breast carcinoma) | intravascular |
Ruttala [27] | 2020 | simple conjugates | Ionidamine | DU-145 (prostate cancer) | intravascular |
Xing [28] | 2018 | loaded in liposomes | DXR | U14 (cervical carcinoma) | intravascular |
Xiong [29] | 2014 | simple conjugates | CIS | SK-OV-3 (ovarian carcinoma) | intraperitoneal |
Zabielska-Koczywas [30] | 2018 | glutathione conjugates | DXR | FFS1 (feline fibrosarcoma) | intravascular |
Zhou [31] | 2016 | folate-calix construct | CIS | 4T1 (breast carcinoma) | intravascular |
First Author | Type of Surface Ligand | Type of Carrier |
---|---|---|
Bao [17] | PEG | liposomes |
Davidi [18] | PEG7 | not used |
Hale [19] | direct surface bond | not used |
Hung [20] | PEG; PEI | not used |
Khademi [21] | chitosan | not used |
Li [22] | direct surface bond | liposomes |
Liu [23] | direct surface bond | nanogel |
Mirrahimi [24] | direct surface bond | nanogel |
Nair [25] | Folic Acid | not used |
Peng [26] | PEG; MBA | not used |
Ruttala [27] | aptamer AS1411 | not used |
Xing [28] | direct surface bond | liposomes |
Xiong [29] | direct surface bond | not used |
Zabielska-Koczywas [30] | glutathione | not used |
Zhou [31] | Folic Acid | not used |
First Author | Route of Administration | Ex Vivo/In Vivo Analysis | Imaging Evaluation |
---|---|---|---|
Bao [17] | intravascular | ex vivo | chromatography |
Davidi [18] | intravascular | ex vivo | atomic absorption spectroscopy |
Khademi [21] | intravascular | ex vivo | NIR fluorescence |
Li [22] | intravascular | in vivo | NIR fluorescence |
Nair [25] | intraperitoneal | ex vivo | ICP-MS |
Ruttala [27] | intravascular | in vivo | FOBI fluorescence imaging |
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Morărașu, Ș.; Iacob, Ș.; Tudorancea, I.; Luncă, S.; Dimofte, M.-G. Targeted Chemotherapy Delivery via Gold Nanoparticles: A Scoping Review of In Vivo Studies. Crystals 2021, 11, 1169. https://doi.org/10.3390/cryst11101169
Morărașu Ș, Iacob Ș, Tudorancea I, Luncă S, Dimofte M-G. Targeted Chemotherapy Delivery via Gold Nanoparticles: A Scoping Review of In Vivo Studies. Crystals. 2021; 11(10):1169. https://doi.org/10.3390/cryst11101169
Chicago/Turabian StyleMorărașu, Ștefan, Ștefan Iacob, Ionuț Tudorancea, Sorinel Luncă, and Mihail-Gabriel Dimofte. 2021. "Targeted Chemotherapy Delivery via Gold Nanoparticles: A Scoping Review of In Vivo Studies" Crystals 11, no. 10: 1169. https://doi.org/10.3390/cryst11101169