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Crystals
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Hydroxyapatite Base Nanocomposites
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Hydroxyapatite Base Nanocomposites

A special issue of Crystals (ISSN 2073-4352). This special issue belongs to the section "Hybrid and Composite Crystalline Materials".

Deadline for manuscript submissions: closed (15 December 2020) | Viewed by 31832

Special Issue Editors

Dr. Réka Barabás

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Guest Editor
Faculty of Chemistry and Chemical Engineering，Babeş-Bolyai University(UBB), Cluj Napoca, Romania
Interests: Hap composites, bioceramics, bio-nanomaterials
Special Issues, Collections and Topics in MDPI journals
Dr. Liliana Bizo

E-Mail Website
Guest Editor
Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, Cluj-Napoca, Romania
Interests: oxide materials, biomaterials, optoelectronic materials, characterization methods (X-ray powder diffraction-XRPD)
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Graziella-Liana Turdean

E-Mail Website1 Website2
Guest Editor
Faculty of Chemistry and Chemical Engineering, Department of Chemical Engineering, Babes-Bolyai University, Arany Janos Street, No. 11, 400028 Cluj-Napoca, Romania
Interests: nano/materials for electrodes; supramolecular and nanostructured redox bio/systems
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Tissue engineering is a very important research field for developing new structural materials for implants. Hydroxyapatite base nanocomposites are promising materials for tissue engineering applications. Hydroxyapatite (Hap) with excellent biocompatibility could be combined with materials with other favorable properties, like enhanced mechanical properties, flexibility, adsorption capacity, porosity, etc.

The nanosized constituent materials of the composites present following advantages:

constituent materials interact at a molecular level, they could build self-assembled structures, the specific surface of nanocomposites is higher, so the adsorption capacity could be enhanced.

As future materials for the new generation implants, Hap-base nanocomposites present enhanced mechanical properties, like higher load-bearing capacity and flexibility in the case of the natural bones.

On the other hand, nanocomposites could be used as coating materials for implants, so their adsorption capacity and porosity are essential factors for the adsorption of active substances with an anti-inflammatory effect or the porosity for new bone tissue formation.

As drug carriers, Hap base nanocomposites present a good opportunity for trapping active substances. The special structures, which could be built using different crosslinking agents, could fix the active substances inside of the composites, and the adsorb different materials on the nanocomposites’ surfaces.

We invite researchers to contribute to the Special Issue on "Hap base nanocomposites"; which is intended to serve as a multidisciplinary forum covering broad aspects of science, technology and the applications of Hap base nanocomposites.

The main topics are, without limitation:

  • Preparation and characterization of bio-nanocomposites
  • Applications of Hap base nanocomposites
  • Special structures of nanocomposites as drug carriers
  • Interdependence of structure and properties of nanocomposites
  • Adsorption and desorption kinetics on Hap base nanocomposites
Assoc. prof. Réka Barabás
Dr. Liliana BIZO
Prof. Dr. Graziella-Liana TURDEAN
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Crystals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanocomposites
  • nanohydroxyapatite
  • nanocomposites
  • drug carriers
  • encapsulation by electrospinning
  • drug delivery

Related Special Issue

Published Papers (6 papers)

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Research

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16 pages, 1423 KiB  
Article
Influence of HAP on the Morpho-Structural Properties and Corrosion Resistance of ZrO2-Based Composites for Biomedical Applications
by Réka Barabás, Carmen Ioana Fort, Graziella Liana Turdean and Liliana Bizo
Crystals 2021, 11(2), 202; https://doi.org/10.3390/cryst11020202 - 19 Feb 2021
Cited by 11 | Viewed by 2316
Abstract
In the present work, ZrO2-based composites were prepared by adding different amounts of antibacterial magnesium oxide and bioactive and biocompatible hydroxyapatite (HAP) to the inert zirconia. The composites were synthesized by the conventional ceramic processing route and morpho-structurally analyzed by X-ray [...] Read more.
In the present work, ZrO2-based composites were prepared by adding different amounts of antibacterial magnesium oxide and bioactive and biocompatible hydroxyapatite (HAP) to the inert zirconia. The composites were synthesized by the conventional ceramic processing route and morpho-structurally analyzed by X-ray powder diffraction (XRPD) and scanning electron microscopy/energy dispersive X-ray spectroscopy (SEM/EDS). Two metallic dental alloys (i.e., Ni–Cr and Co–Cr) coated with a chitosan (Chit) membrane containing the prepared composites were exposed to aerated artificial saliva solutions of different pHs (i.e., 4.3, 5, 6) and the corrosion resistances were investigated by electrochemical impedance spectroscopy technique. The obtained results using the two investigated metallic dental alloys shown quasi-similar anticorrosive properties, having quasi-similar charge transfer resistance, when coated with different ZrO2-based composites. This behavior could be explained by the synergetic effect between the diffusion process through the Chit-composite layer and the roughness of the metallic electrode surface. Full article
(This article belongs to the Special Issue Hydroxyapatite Base Nanocomposites)
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13 pages, 3034 KiB  
Article
Effect of Ultrasound Irradiation on the Synthesis of Hydroxyapatite/Titanium Oxide Nanocomposites
by A. K. Sánchez-Hernández, J. Martínez-Juárez, J. J. Gervacio-Arciniega, R. Silva-González and M. J. Robles-Águila
Crystals 2020, 10(11), 959; https://doi.org/10.3390/cryst10110959 - 22 Oct 2020
Cited by 13 | Viewed by 2636
Abstract
Bioceramic materials, such as hydroxyapatite, Ca10(PO4)6(OH)2, (HAp), can be chemically bound to bone tissue; since they are bioactive and biocompatible. HAp, titanium oxide (TiO2), and hydroxyapatite/titanium oxide (HAp/TiO2) nanocomposite nanoparticles were [...] Read more.
Bioceramic materials, such as hydroxyapatite, Ca10(PO4)6(OH)2, (HAp), can be chemically bound to bone tissue; since they are bioactive and biocompatible. HAp, titanium oxide (TiO2), and hydroxyapatite/titanium oxide (HAp/TiO2) nanocomposite nanoparticles were obtained by ultrasound irradiation assisted by sol-gel and co-precipitation methods at different time intervals, using Ca(NO3)2•4H2O, (NH4)2HPO4, and TiOSO4•xH2O as calcium, phosphorus, and titanium sources, respectively. HAp, TiO2, and HAp/TiO2 nanocomposite powders were characterized by X-ray Diffraction (XRD) and Raman Spectroscopy. The percentages of anatase phase for TiO2 and of monoclinic and hexagonal phases for HAp were quantified by Rietveld refinement. Furthermore, sample crystallinity in each material was enhanced by increasing the ultrasound irradiation time. The nanoparticle shape was semi-spherical, agglomerated, and between 17 and 20 nm in size. The agglomeration of particles in the samples was corroborated with a Field Emission Scanning Electron Microscope (FESEM). Full article
(This article belongs to the Special Issue Hydroxyapatite Base Nanocomposites)
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18 pages, 5959 KiB  
Article
Fabrication of Poly(pentaerythritol tetrakis (3-mercaptopropionate)/dipentaerythritol penta-/hexa-acrylate)HIPEs Macroporous Scaffold with Alpha Hydroxyapatite via Photopolymerization for Fibroblast Regeneration
by Muhammad Imran Azman, Nunthawan Kwangsawart, Jitima Preechawong, Manit Nithitanakul and Pornsri Sapsrithong
Crystals 2020, 10(9), 746; https://doi.org/10.3390/cryst10090746 - 24 Aug 2020
Cited by 3 | Viewed by 3263
Abstract
Synthetic biomaterials that can be structured into porous scaffolds for support cell growth have played a role in developing the field of tissue engineering. This research focused on combination of biodegradable emulsion template along with the assisting of low-cost polymerization reaction. The appendage [...] Read more.
Synthetic biomaterials that can be structured into porous scaffolds for support cell growth have played a role in developing the field of tissue engineering. This research focused on combination of biodegradable emulsion template along with the assisting of low-cost polymerization reaction. The appendage of ester-based surfactant, Hypermer B246, played a vital role which gave an outstanding dispersion in HIPEs system and degradability. PolyHIPEs were prepared by using domestic ultraviolet light source for producing a multiscale porosity material. The morphology showed a promising result of poly(pentaerythritol tetrakis (3-mercaptopropionate)/dipentaerythritol penta-/hexa-acrylate)HIPEs with varied Hypermer B246 surfactant concentration resulting in the pores size increased in between 51.2 ± 9.8 µm to 131.4 ± 26.32 µm. Cellular moieties of poly(TT/DPEHA) HIPEs were confirmed by using SEM while inclusion of hydroxyapatite were confirmed by SEM, FTIR and EDX-SEM and quantified by thermogravimetric analysis. The maximum stress and compressive modulus of the obtained materials were significantly enhanced with HA up to five percent by weight. Poly(TT/DPEHA)HIPEs with HA showed the ability for the cell attachment and the adhesion/proliferation of the cells, suggested that poly(TT/DPEHA) HIPEs with HA were suitable for biomaterial application. Full article
(This article belongs to the Special Issue Hydroxyapatite Base Nanocomposites)
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Review

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51 pages, 8817 KiB  
Review
Three-Dimensional Printing of Hydroxyapatite Composites for Biomedical Application
by Yanting Han, Qianqian Wei, Pengbo Chang, Kehui Hu, Oseweuba Valentine Okoro, Amin Shavandi and Lei Nie
Crystals 2021, 11(4), 353; https://doi.org/10.3390/cryst11040353 - 29 Mar 2021
Cited by 36 | Viewed by 7036
Abstract
Hydroxyapatite (HA) and HA-based nanocomposites have been recognized as ideal biomaterials in hard tissue engineering because of their compositional similarity to bioapatite. However, the traditional HA-based nanocomposites fabrication techniques still limit the utilization of HA in bone, cartilage, dental, applications, and other fields. [...] Read more.
Hydroxyapatite (HA) and HA-based nanocomposites have been recognized as ideal biomaterials in hard tissue engineering because of their compositional similarity to bioapatite. However, the traditional HA-based nanocomposites fabrication techniques still limit the utilization of HA in bone, cartilage, dental, applications, and other fields. In recent years, three-dimensional (3D) printing has been shown to provide a fast, precise, controllable, and scalable fabrication approach for the synthesis of HA-based scaffolds. This review therefore explores available 3D printing technologies for the preparation of porous HA-based nanocomposites. In the present review, different 3D printed HA-based scaffolds composited with natural polymers and/or synthetic polymers are discussed. Furthermore, the desired properties of HA-based composites via 3D printing such as porosity, mechanical properties, biodegradability, and antibacterial properties are extensively explored. Lastly, the applications and the next generation of HA-based nanocomposites for tissue engineering are discussed. Full article
(This article belongs to the Special Issue Hydroxyapatite Base Nanocomposites)
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22 pages, 43080 KiB  
Review
Encapsulation of Calcium Phosphates on Electrospun Nanofibers for Tissue Engineering Applications
by Arputharaj Joseph Nathanael and Tae Hwan Oh
Crystals 2021, 11(2), 199; https://doi.org/10.3390/cryst11020199 - 18 Feb 2021
Cited by 14 | Viewed by 4214
Abstract
In the field of tissue engineering, electrospinning is a versatile technique that provides nanofibers with structure similar to that of the extracellular matrix owing to their flexible functionalization. Considerable developments in electrospinning have been made to produce engineered electrospun nanofibers for different biomedical [...] Read more.
In the field of tissue engineering, electrospinning is a versatile technique that provides nanofibers with structure similar to that of the extracellular matrix owing to their flexible functionalization. Considerable developments in electrospinning have been made to produce engineered electrospun nanofibers for different biomedical applications. Various biopolymers possess good biocompatibility and biodegradability and are nontoxic in nature. Modification of these biopolymers can enhance or elicit certain properties. One technique of modification is the incorporation of certain inorganic ions or components that can enhance its specific functional characteristics such as mineralization, osseointegration, and bioactivity. Incidentally, calcium phosphate (CaP) materials have proven to be suitable and versatile for biopolymer incorporation and exploration because of their inherent bioactivity and being key mineral constituents of bone and teeth. The addition of CaP materials to polymers enhances cell infiltration, differentiation, and biomineralization. We aim to provide a broad overview of CaP material (particularly hydroxyapatite (HA))-incorporated electrospun nanocomposite fibers and their possible applications in tissue engineering. Some key polymer/HA composites were discussed in detail, and a brief discussion on other polymer/HA composites was also provided. Finally, we discussed the future perspectives of this interesting and emerging composite material fabricated via electrospinning. Full article
(This article belongs to the Special Issue Hydroxyapatite Base Nanocomposites)
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18 pages, 1929 KiB  
Review
Hydroxyapatite Based Materials for Bone Tissue Engineering: A Brief and Comprehensive Introduction
by Hui Shi, Ziqi Zhou, Wuda Li, Yuan Fan, Zhihua Li and Junchao Wei
Crystals 2021, 11(2), 149; https://doi.org/10.3390/cryst11020149 - 01 Feb 2021
Cited by 124 | Viewed by 11503
Abstract
Hydroxyapatite (HA) is widely used in bone tissue engineering for its bioactivity and biocompatibility, and a growing number of researchers are exploring ways to improve the physical properties and biological functions of hydroxyapatite. Up to now, HA has been used as inorganic building [...] Read more.
Hydroxyapatite (HA) is widely used in bone tissue engineering for its bioactivity and biocompatibility, and a growing number of researchers are exploring ways to improve the physical properties and biological functions of hydroxyapatite. Up to now, HA has been used as inorganic building blocks for tissue engineering or as nanofillers to blend with polymers, furthermore, various methods such as ion doping or surface modification have been also reported to prepare functionalized HA. In this review, we try to give a brief and comprehensive introduction about HA-based materials, including ion-doped HA, HA/polymer composites and surface modified HA and their applications in bone tissue engineering. In addition, the prospective of HA is also discussed. This review may be helpful for researchers to get a general understanding about the development of hydroxyapatite based materials. Full article
(This article belongs to the Special Issue Hydroxyapatite Base Nanocomposites)
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