Crystallization Process and Simulation Calculation, Fourth Edition

Dear colleagues,

Following the remarkable success of the previous editions of this topic, entitled “Crystallization Process and Simulation Calculation” (First Edition, Second Edition, and Third Edition), we are pleased to announce the launch of the Fourth Edition.

As an important unit of operation, crystallization is a process in which nucleation, growth, agglomeration, and breakage are regulated to produce high-quality crystals and achieve efficient separation and purification. In recent years, there have been some new research developments in crystallization processes. Process intensification techniques such as ultrasound and wet grinding are used to enhance the nucleation and breakage processes in crystallization, thereby preparing ultrafine powders and cube-like crystals. Spherical crystallization technology prepares spherical crystalline particles through crystal growth or agglomeration processes. Continuous crystallization has also gained growing interest due to its high productivity and consistency in product quality. These studies could provide innovative process design strategies and control methods for crystallizing a product with the required quality attributes and a predictable performance.

Since crystallization processes often exhibit strong coupling, nonlinearity, and large lagging, designing a robust, well-characterized process to efficiently crystallize and prepare high-quality crystalline products remains a considerable challenge. The development of Process Analytical Technology, which can provide fast and accurate inline and online measurements, is of great importance in the design and control of crystallization processes. Simulation technology, e.g., molecular dynamics simulation and hydrodynamics simulation technology, can provide time- and location-dependent insights into the process at multiple scales. These experimental and simulation tools can greatly help to further investigate crystallization processes.

This Special Issue, “Crystallization Processes and Simulation Calculations, Fourth Edition”, serves to provide a platform for researchers to report their results and findings on crystallization process technologies, simulation and process analytical technologies, and relevant crystallization studies. We welcome high-quality submissions that address experimental, computational, or theoretical aspects of crystallization, and we particularly encourage interdisciplinary contributions that integrate process innovation with simulation and control strategies.

Dr. Mingyang Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Crystals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• nucleation and growth
• agglomeration and breakage
• process analytical technology
• process intensification
• continuous crystallization
• spherical crystallization
• molecular dynamics simulation
• hydrodynamics simulation

• Crystallization Process and Simulation Calculation in Crystals (12 articles)
• Crystallization Process and Simulation Calculation, Second Edition in Crystals (16 articles)
• Crystallization Process and Simulation Calculation, Third Edition in Crystals (9 articles)