Latest Trends in Coatings of Medical Implants

A special issue of Coatings (ISSN 2079-6412). This special issue belongs to the section "Surface Coatings for Biomedicine and Bioengineering".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 1756

Special Issue Editor


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Guest Editor
Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), VU University of Amsterdam, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, The Netherlands
Interests: bone tissue engineering; biomaterials; drug delivery; osteoinduction; dental implant; bone repair
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Special Issue Information

Dear Colleagues,

The advent of biomimetic coatings in the field of bone regeneration and repair has commanded considerable attention due to their intrinsic biocompatibility and osteoconductivity. By imbuing these coatings with osteoinductive properties through the incorporation of agents such as bone morphogenetic protein 2 (BMP-2) within the crystalline lattice under physiological conditions, they can elicit a robust response conducive to bone growth. When in contact with multinucleated cells, including osteoclasts and foreign body giant cells, the biomimetic calcium phosphate coating orchestrates a precisely modulated, gradual release of growth factors. This process occurs via cell-mediated coating degradation, mirroring a physiologically orchestrated release mechanism.

The primary objective of this Special Issue is to delineate the forefront of research and development in the field of biomimetic coatings for biomaterials. Discussions will delve into intricate topics, encompassing coating methodologies, physicochemical attributes and their potential role as carriers for therapeutic agents, as well as insights from preclinical investigations and clinical applications in the fields of implant dentistry and orthopedics. It is envisioned that these biomimetic coatings will reshape paradigms in drug delivery mechanisms and advance tissue engineering.

Yours sincerely,

Dr. Yuelian Liu
Guest Editor

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Keywords

  • bone tissue engineering
  • biomaterials
  • drug delivery
  • osteoinduction
  • dental implant
  • bone repair

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Published Papers (1 paper)

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Research

12 pages, 3090 KiB  
Article
Ultrasound-Activated Multifunctional Bioactive Calcium Phosphate Composites for Enhanced Osteosarcoma Treatment
by Mingjie Wang, Dong Xu, Chunfeng Xu, Menghong Li, Chang Du and Yuelian Liu
Coatings 2024, 14(10), 1267; https://doi.org/10.3390/coatings14101267 - 2 Oct 2024
Cited by 1 | Viewed by 1436
Abstract
Bone defects caused by surgical interventions and the challenges of tumor recurrence and metastasis due to residual cancer cells significantly complicate the treatment of osteosarcoma (OS). To address these complex clinical challenges, we propose an innovative therapeutic strategy that centers on an ultrasound-activated [...] Read more.
Bone defects caused by surgical interventions and the challenges of tumor recurrence and metastasis due to residual cancer cells significantly complicate the treatment of osteosarcoma (OS). To address these complex clinical challenges, we propose an innovative therapeutic strategy that centers on an ultrasound-activated multifunctional bioactive calcium phosphate (BioCaP) composite. A modified curcumin (mcur)-mediated wet biomimetic mineralization process was used to develop an anticancer-drug-integrated multifunctional BioCaP (mcur@BioCaP), exploring its potential biological effects for OS treatment activated by ultrasound (US). The mcur@BioCaP demonstrates a drug dose-dependent, tailorable alteration in its micro/nanostructure. The US stimulus significantly enhanced this composite to generate reactive oxygen species (ROS) in cancer cells. The results show that the OS cell viability of the mcur@BioCaP with US is 62.2% ± 6.3%, the migration distance is 63.9% ± 6.6%, and the invaded OS cell number is only 57.0 ± 3.7 OS cells per version, which were all significantly lower than US or mcur@BioCaP alone, suggesting that the anticancer, anti-migratory and anti-invasive effects of mcur@BioCaP on OS 143B cells were amplified by ultrasonic stimulation. This amplification can be attributed to the US-activated ROS production from the drug molecules, which regulates the wet biomimetic mineralization of the multifunctional composite. Furthermore, mcur@BioCaP with US increased calcium nodule formation by 1.8-fold, which was significantly higher than mcur@BioCaP or US group, indicating its potential in promoting bone regeneration. The anticancer and osteogenic potentials of mcur@BioCaP were found to be consistent with the mcur concentration in the multifunctional composite. Our research provides a novel therapeutic approach that leverages a multifunctional biomimetic mineral and ultrasonic activation, highlighting its potential applications in OS therapy. Full article
(This article belongs to the Special Issue Latest Trends in Coatings of Medical Implants)
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