Molecular Insights into Gut Biology: Stem Cells, Organoids, and Microbiota–Immune Interactions
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 853
Special Issue Editor
Interests: organoid; intestinal stem cell; immunecheckpoint inhibitor adverse effect; microbiota; cell death
Special Issue Information
Dear Colleagues,
This Special Issue, titled “Molecular Insights into Gut Biology: Stem Cells, Organoids, and Microbiota–Immune Interactions” will bring together cutting-edge research illuminating the molecular mechanisms governing gut homeostasis, regeneration, and immune regulation. With the gastrointestinal tract representing a dynamic and multilayered environment, this Special Issue will showcase studies focusing on intestinal stem cell biology, the development and application of gut-derived organoids, and the complex crosstalk between the microbiota and the host immune system.
We welcome original research articles and comprehensive reviews exploring the following topics:
- Stem-cell-mediated epithelial regeneration and niche maintenance;
- Organoid models for elucidating gut physiology, pathophysiology, and therapeutic screening;
- Molecular mediators through which the microbiota influence immune cell function and gut barrier integrity;
- Synergies among stem cells, organoids, and microbial–immune dynamics in disease contexts such as inflammatory bowel disease, infection, or cancer.
By employing molecular biology, high-throughput omics, and advanced in vitro and in vivo modelling, this Special Issue will translate mechanistic insights into novel diagnostic and therapeutic approaches. Interdisciplinary, translational, and innovative submissions are highly encouraged, in order to advance our understanding of gut biology through molecular precision and integrative perspectives.
Aims & Scope
Aim:
We aim to provide an academic platform showcasing research that deciphers the molecular underpinnings of gut biology, with an emphasis on stem cell dynamics, organoid systems, and microbiota–immune interactions.
The scope includes (but is not limited to) the following topics:
- The molecular regulation of intestinal stem cells and epithelial renewal;
- The development and application of gut organoid technologies for modeling physiology and disease;
- Mechanisms through which the gut microbiota modulates immune responses at the mucosal interface;
- Integrated models combining organoids and microbial or immune components;
- The use of omics technologies, computational approaches, and translational models to uncover molecular pathways;
- Pathological insights into IBD, microbial dysbiosis, infection, cancer, and regenerative medicine.
Dr. Shaoyi Zhang
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- intestinal stem cells
- intestinal organoids
- gut–microbiota interaction
- mucosal immunology
- molecular mechanisms
- gut epithelial regeneration
- microbiota–immune crosstalk
- organoid disease models
- intestinal homeostasis
- molecular gut biology
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