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Insights from Genetics, Epigenetics, and Microbiome Research in Obesity: Integrative Approaches to Understand Metabolic Disorders

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Bioinformatics and Systems Biology".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 877

Special Issue Editor


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Guest Editor
Pennington Biomedical Research Center, Baton Rouge, LA, USA
Interests: statistical methodologies; genomics

Special Issue Information

Dear Colleagues,

The obesity epidemic poses a significant global health challenge, impacting numerous aspects of metabolic health and quality of life. While traditional approaches have emphasized lifestyle factors, such as diet and exercise, recent research has increasingly highlighted the intricate roles of genetics, epigenetics, and the microbiome in shaping obesity risk and progression. However, research in these areas presents significant challenges. The complexity of genetic influence, the dynamic nature of epigenetic modifications, and the highly variable composition of the microbiome all make it difficult to establish clear causal relationships and develop effective interventions. Additionally, integrating data from these diverse fields requires sophisticated computational tools and large, well-designed studies. Despite these challenges, by focusing on the critical areas of genetics, epigenetics, and the microbiome, this Special Issue aims to advance our understanding of the complex nature of obesity and contribute to the development of more effective prevention and treatment strategies. Research applying the state-of-the-art artificial intelligence concepts is highly encouraged.

Dr. Shengping Yang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obesity
  • epigenetics
  • microbiom
  • genetics
  • bioinformatics

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Published Papers (1 paper)

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Review

17 pages, 6230 KiB  
Review
Gut–Adipose Tissue Axis and Metabolic Health
by Sanja Borozan, Cornelius J. Fernandez, Adnan Samee and Joseph M. Pappachan
Curr. Issues Mol. Biol. 2025, 47(6), 424; https://doi.org/10.3390/cimb47060424 - 6 Jun 2025
Viewed by 428
Abstract
The gut–adipose tissue axis plays a crucial role in metabolic health. It is a two-way communication pathway between the gastrointestinal tract and adipose tissue. This axis influences physiological processes vital for maintaining metabolic health, including energy homeostasis, lipid metabolism, and inflammation. Emerging research [...] Read more.
The gut–adipose tissue axis plays a crucial role in metabolic health. It is a two-way communication pathway between the gastrointestinal tract and adipose tissue. This axis influences physiological processes vital for maintaining metabolic health, including energy homeostasis, lipid metabolism, and inflammation. Emerging research suggests that the gut microbiota, composed of trillions of microorganisms residing in the intestines, significantly impacts this axis by modulating host metabolism. An imbalance in the gut microbiota (dysbiosis) has been linked to obesity, insulin resistance, and other metabolic disorders. Innovative therapeutic strategies and dietary interventions aimed at modulating the gut–adipose tissue axis have shown encouraging results in improving metabolic health. A deeper critical understanding of the gut–adipose tissue axis is, therefore, essential in understanding the pathophysiology of metabolic disorders so that targeted interventions can be developed to prevent and treat these metabolic disorders. This article highlights the need for integrative approaches that consider both gastrointestinal and adipose functions in metabolic health management. Full article
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