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Children
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Insights in Children with Allergy
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Insights in Children with Allergy

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Allergy and Immunology".

Deadline for manuscript submissions: 1 August 2025 | Viewed by 2812

Special Issue Editor

Dr. Rita Nocerino

E-Mail Website
Guest Editor
1. Department of Translational Medical Science, University of Naples Federico II, Naples, Italy
2. ImmunoNutritionLab at CEINGE Advanced Biotechnologies, University of Naples Federico II, Naples, Italy
3. Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, Rome, Italy
Interests: allergy diagnosis; allergic diseases; immune response; immunology; child nutrition; inflammation; gastroenterology; epidemiology; pediatrics

Special Issue Information

Dear Colleagues,

Allergic diseases in children have been a growing concern over the past few decades, with significant increases in prevalence observed in conditions such as atopic dermatitis, asthma, and food allergies. These conditions can severely impact the quality of life of children and their families, necessitating a comprehensive approach to understanding and managing pediatric allergies.

This Special Issue aims to collate the latest research and insights into the mechanisms, risk factors diagnosis, management, and prevention of allergic diseases in children. By focusing on cutting-edge studies, we seek to provide a platform for the dissemination of knowledge that can improve clinical practices and patient outcomes.

Recent advancements in the field have highlighted the role of early life nutrition, genetic, environmental, and immunological factors in the development and progression of allergic diseases in children. Studies have shown that early diagnosis and intervention are crucial for managing these conditions effectively.

We invite original research articles, comprehensive reviews, and clinical studies that explore the following:

  • The epidemiology of pediatric allergies;
  • Novel diagnostic methods and biomarkers;
  • Innovative management and treatment strategies;
  • Preventive measures and early intervention;
  • Growth of children with allergy;
  • Economic burden of allergic diseases;
  • The psychosocial impact of allergies on children and their families.

Dr. Rita Nocerino
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pediatric allergies
  • atopic march
  • economic burden
  • food allergies
  • immunotherapy
  • diagnostic methods
  • environmental factors
  • genetic predisposition
  • allergy management
  • preventive healthcare

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  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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14 pages, 2002 KiB  
Article
Evolutive Study of Dietary Aspects and Intestinal Microbiota of Pediatric Cohort with Cow’s Milk Protein Allergy
by Ana M. Castro, Sandra Navarro, Ignacio Carvajal, Agueda García, Marta Suárez, Paula Toyos, Silvia Rodríguez, Santiago Jimenez, David González, Cristina Molinos, David Pérez-Solís, Porifirio Fernández, Abelardo Margolles, Juan J. Díaz-Martín, Isabel Gutiérrez-Díaz and Susana Delgado
Children 2024, 11(9), 1113; https://doi.org/10.3390/children11091113 - 12 Sep 2024
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Abstract
Background: One of the most common food allergies in the pediatric population is allergy to cow’s milk protein (CMPA). Treatment consists of avoiding cow’s milk proteins in lactating mothers and/or using therapeutic formulas based on hydrolysates or vegetable formulas. In infants with CMPA [...] Read more.
Background: One of the most common food allergies in the pediatric population is allergy to cow’s milk protein (CMPA). Treatment consists of avoiding cow’s milk proteins in lactating mothers and/or using therapeutic formulas based on hydrolysates or vegetable formulas. In infants with CMPA at diagnosis, a different gut microbial profile has been found compared to healthy children, with a reduction in beneficial bacteria. The aim of this study was to evaluate changes in the gut microbiota profile and its metabolites, dietary patterns and anthropometric variables in a pediatric cohort with CMPA after six months on a restrictive diet compared to healthy controls. Methods: In total, 21 patients diagnosed with CMPA and a control group of 24 healthy infants participated in this study. The fecal microbiota of all participants were investigated by metataxonomic analysis of 16S rDNA amplicons, and fecal short-chain fatty acids were measured by gas chromatography. Epidemiological assessment and dietary questionnaires were carried out for both groups. Results: Regarding growth, no significant differences were found, but differences in dietary intake of some macro- and micronutrients were observed. Patients who were breastfed at six months had higher bifidobacteria and lipid intakes than patients fed with hydrolyzed formulas. Conclusions: Although the growth of CMPA infants fed with therapeutic formula is similar to breastfed CMPA infants, there are differences in microbiota composition and macronutrient intake that underline the importance of continued breastfeeding in CMPA cases. Full article
(This article belongs to the Special Issue Insights in Children with Allergy)
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14 pages, 409 KiB  
Systematic Review
Food Allergy-Related Bullying in Pediatric Patients: A Systematic Review
by Rita Nocerino, Caterina Mercuri, Vincenzo Bosco, Greta Aquilone, Assunta Guillari, Silvio Simeone and Teresa Rea
Children 2024, 11(12), 1485; https://doi.org/10.3390/children11121485 - 5 Dec 2024
Cited by 1 | Viewed by 1061
Abstract
Background: Food allergy (FA)-related bullying is a significant public health concern affecting pediatric patients. This systematic review investigates the prevalence, characteristics, and psychosocial impact of FA-related bullying, as well as current intervention strategies within educational and healthcare settings. Methods: A systematic literature search [...] Read more.
Background: Food allergy (FA)-related bullying is a significant public health concern affecting pediatric patients. This systematic review investigates the prevalence, characteristics, and psychosocial impact of FA-related bullying, as well as current intervention strategies within educational and healthcare settings. Methods: A systematic literature search was conducted across the PubMed, Web of Science, and CINAHL databases, covering publications up to February 2024. The review followed PRISMA guidelines and included studies on children and adolescents (0–18 years) diagnosed with FAs. Studies were selected based on eligibility criteria and assessed for quality using the Newcastle–Ottawa Scale. Results: The initial search identified a total of 260 records (6 from scientific databases and 254 from registries). Twenty-six studies met the inclusion criteria. The findings of these studies reveal that FA-related bullying is prevalent, with rates varying between 17% and 60%, depending on the study population and methods. Bullying often involves verbal teasing, social exclusion, and physical threats using allergens, presenting both psychological and physical risks. Psychological consequences include increased anxiety, depression, and social withdrawal, which persist over time, significantly impacting quality of life for both children and their families. Notably, bullying often occurs in school settings, emphasizing the need for targeted interventions. Conclusion: FA-related bullying profoundly affects mental health and quality of life for affected children and their families. Interventions, such as school-based allergy education programs and policies promoting inclusivity and safety, have shown promise in reducing bullying incidents. A collaborative approach involving healthcare providers, educators, and policymakers is essential to mitigate the impact of FA-related bullying and improve outcomes for affected children. Full article
(This article belongs to the Special Issue Insights in Children with Allergy)
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