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Children
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Health Challenges and Solutions in Pediatric Endocrine Disease: Early Prevention...
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Health Challenges and Solutions in Pediatric Endocrine Disease: Early Prevention and Management

A special issue of Children (ISSN 2227-9067).

Deadline for manuscript submissions: closed (5 December 2025) | Viewed by 962

Special Issue Editors

Dr. Letteria Anna Morabito

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Guest Editor
Facoltà di Medicina e Chirurgia, Università degli Studi di Messina, Messina, Italy
Interests: pediatric endocrinology; childhood obesity; adrenal disease in childhood
Dr. Giorgia Pepe

E-Mail
Guest Editor
Pediatric Unit, “G. Martino” University Hospital, 98122 Messina, Italy
Interests: pediatric endocrinology; childhood obesity; minipuberty

Special Issue Information

Dear Colleagues,

In recent years, significant progress has been made in management strategies for pediatric endocrine disorders. 

A key aspect of these advances is the improvement in diagnostic techniques, which has enabled easier access to advanced investigations, such as genetic analysis. These tools have not only deepened our understanding of many endocrine diseases but have also improved our capacity for early diagnosis and personalized therapies. 

The enhanced knowledge of childhood growth disorders and obesity (both in early prevention and treatment) has transformed the clinical management of affected patients.

This Special Issue aims to address the diagnostic and therapeutic challenges that characterize these disorders. We invite original research articles, systematic or narrative reviews, and clinically relevant case reports with literature reviews focusing on early identification and prevention strategies, novel biomarkers, and advances in genetic and hormonal profiling. Special consideration will be given to works exploring the most pressing clinical challenges and proposing innovative solutions in pediatric endocrinology.

Dr. Letteria Anna Morabito
Dr. Giorgia Pepe
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pediatric endocrine disease
  • diagnostic challenges
  • genetic investigations
  • new therapies in childhood obesity
  • early prevention of childhood obesity
  • growth disorders
  • genetic and hormonal profiling
  • precision medicine

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Review

15 pages, 920 KB  
Review
Endocrine Dysfunctions After Pediatric Traumatic Brain Injury: Present Insights and Future Directions
by Ignazio Cammisa, Elena Malavolta, Giorgio Sodero, Donato Rigante and Clelia Cipolla
Children 2025, 12(11), 1484; https://doi.org/10.3390/children12111484 - 3 Nov 2025
Viewed by 740
Abstract
Traumatic brain injury (TBI) in childhood is a major global health concern and a leading cause of morbidity and mortality in the pediatric population. Its incidence is rising worldwide, with early childhood and adolescence representing the most vulnerable age groups. Beyond acute neurological [...] Read more.
Traumatic brain injury (TBI) in childhood is a major global health concern and a leading cause of morbidity and mortality in the pediatric population. Its incidence is rising worldwide, with early childhood and adolescence representing the most vulnerable age groups. Beyond acute neurological injury, post-traumatic endocrine dysfunction has emerged as an underrecognized but clinically significant sequela, with potential long-term consequences for growth, puberty, metabolism, and overall quality of life. The hypothalamic–pituitary axis (HPA) is uniquely vulnerable due to its anatomical and vascular characteristics, making pituitary cells—particularly somatotrophs and gonadotrophs—susceptible to ischemic, traumatic, and inflammatory damage. Reported prevalence of post-TBI pituitary dysfunction in children ranges from 5 to 57%, reflecting a deep heterogeneity in injury severity, diagnostic methods, and timing of evaluations. Growth hormone deficiency (GHD) is the most frequently reported abnormality, with presentations varying from transient to persistent forms. Gonadal axis disturbances, including hypogonadotropic hypogonadism and, less commonly, central precocious puberty, highlight the impact of TBI on pubertal development. Adrenal dysfunctions, though less frequent, may be life-threatening if unrecognized, while posterior pituitary disorders, such as diabetes insipidus, usually revealed acutely, are often transient. Importantly, many endocrine sequelae manifest months to years after the initial trauma, complicating a timely diagnosis. Current evidence underscores the need for structured, longitudinal endocrine surveillance after pediatric TBI, with baseline and follow-up assessments at defined intervals. Early recognition and intervention, including hormone replacement when appropriate, may improve neurocognitive recovery and overall rehabilitation outcomes. Future multicenter studies and standardized screening protocols should be considered essential to clarify incidence, natural history, and optimal management strategies for post-traumatic endocrine dysfunction in children. Full article
(This article belongs to the Special Issue Health Challenges and Solutions in Pediatric Endocrine Disease: Early Prevention and Management)
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