Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
2.0
2.4
Journals
Children
Special Issues
Rheumatic Diseases in Children
share announcement

Rheumatic Diseases in Children

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Surgery".

Deadline for manuscript submissions: closed (20 April 2023) | Viewed by 5725

Special Issue Editor

Dr. Emanuela Del Giudice

E-Mail Website
Guest Editor
Pediatric and Neonatology Unit, Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Polo Pontino, Latina, Italy
Interests: pediatric rheumatic diseases; autoimmune diseases; autoinflammatory diseases; translational research
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pediatric rheumatology is a developing field, with important links to other clinical specialties. The importance of this linkage was also seen during the pandemic period with the study of the role of inflammation in COVID 19 disease and the emerging role of anti-rheumatic drugs for its treatment.

Rheumatic diseases in children embrace both conditions that are unique to children and others that are also found in adults but require a different, age-related approach. They are represented by several disorders including autoimmune diseases, non-inflammatory pain syndromes, inflammatory disorders, as well as disorders of the innate immune system such as autoinflammatory diseases. Early recognition and treatment of these conditions are fundamental for the management of these patients.

Moreover, recent advances in healthcare, evidence-based medicine, a translational approach and the focus on children’s needs have all improve significantly prognosis and quality of life in children and their families.

The purpose of this Special Issue of Children is to collect contributions related to autoimmune and rheumatic disorders practice and research in children.

We welcome reviews and original research considering novel approaches, as well as identifying gaps in knowledge. Description of interesting case reports will also be appreciated. The volume is intended to encourage and promote multidisciplinary collaboration among laboratory and clinical researchers.

I look forward to receiving your contributions.

Dr. Emanuela Del Giudice
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pediatric rheumatic diseases
  • autoimmune diseases
  • autoinflammatory diseases
  • non-inflammatory pain syndromes
  • inflammation
  • multidisciplinary

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

9 pages, 620 KiB  
Article
Recurrent Fever with Oral Lesions in Egyptian Children: A Familial Mediterranean Fever Diagnosis Not to Be Missed
by Ahmed Omran, Ahmed Abdelrahman, Yasmine Gabr Mohamed, Mohamed Osama Abdalla, Eman R. Abdel-Hamid and Samar Elfiky
Children 2022, 9(11), 1654; https://doi.org/10.3390/children9111654 - 29 Oct 2022
Cited by 1 | Viewed by 3147
Abstract
Objectives: the aim of this study was to describe the genetic and clinical features of familial Mediterranean fever (FMF) in a group of Egyptian children. Materials and methods: This cross-sectional observational study included 65 children diagnosed with FMF according to the (Eurofever/PRINTO) classification [...] Read more.
Objectives: the aim of this study was to describe the genetic and clinical features of familial Mediterranean fever (FMF) in a group of Egyptian children. Materials and methods: This cross-sectional observational study included 65 children diagnosed with FMF according to the (Eurofever/PRINTO) classification criteria. The complete blood count (CBC), and acute phase reactants such as Serum amyloid A (SAA), and C-reactive protein (CRP) were all measured during the febrile episode. Mutation analysis for the MEFV gene was carried out for all subjects. Results: A total of 65 patients with FMF were included in the study. The first clinical manifestation was recurrent fever in all patients. Recurrent oral lesions accompanied fever in 63% of cases, abdominal pain in 31%, and musculoskeletal pain in 6%. The mean SAA level was 162.5 ± 85.78 mg/L. MEFV mutations were detected in 56 patients (86%). Among these patients, 6 (10.7%) were homozygous, while 44 (78.6%) were heterozygous. The most frequently observed mutation was E148Q 24 (37.5%), followed by M694I 18 (32.1%), and V726A 13 (20.3%). Half of the patients with oral lesions were E148Q positive, however abdominal pain was found to be higher in the patients with the M694I mutation. Conclusion: Recurrent fever with oral lesions could be an important atypical presentation of FMF in Egyptian children that should not be ignored and/or missed. Full article
(This article belongs to the Special Issue Rheumatic Diseases in Children)
►▼ Show Figures

Figure 1

Review

Jump to: Research

15 pages, 888 KiB  
Review
Gastrointestinal Involvement in Children with Systemic Lupus Erythematosus
by Angela Mauro, Teresa Giani, Clelia Di Mari, Martina Sandini, Antonella Talenti, Valentina Ansuini, Luigi Biondi, Giovanni Di Nardo and Luca Bernardo
Children 2023, 10(2), 309; https://doi.org/10.3390/children10020309 - 06 Feb 2023
Cited by 4 | Viewed by 2151
Abstract
Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder. When it presents before the age of 18 years (childhood-onset systemic lupus erythematosus, cSLE), the disease course tends to be more severe with a higher rate of organ involvement and requires an early diagnosis. [...] Read more.
Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder. When it presents before the age of 18 years (childhood-onset systemic lupus erythematosus, cSLE), the disease course tends to be more severe with a higher rate of organ involvement and requires an early diagnosis. Gastrointestinal involvement in cSLE is rare and scarcely reported in the literature. Any organ of the gastrointestinal system may be affected, either as a direct consequence of the disease, as a subsequent complication, or as an adverse drug event. Abdominal pain is the most common GI symptom, it can be diffuse or well localized, and can underline different conditions such as hepatitis, pancreatitis, appendicitis, peritonitis, or enteritis. cSLE may have an alteration of the intestinal barrier with features of protein-losing enteropathy or, in genetically predisposed patients, may develop associated autoimmune disorders such as Coeliac Disease or Autoimmune Hepatitis. The aim of this manuscript is to provide a narrative review of gastrointestinal manifestations in cSLE focused on hepatic, pancreatic, and intestinal involvement. A comprehensive literature search based on the PubMed database was performed. Full article
(This article belongs to the Special Issue Rheumatic Diseases in Children)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop