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Children
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New Research Progress on Endocrine Disorders in Infants, Children, and...
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New Research Progress on Endocrine Disorders in Infants, Children, and Adolescents

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Endocrinology".

Deadline for manuscript submissions: 10 September 2024 | Viewed by 1281

Special Issue Editors

Prof. Dr. Stefano Zucchini

E-Mail Website
Guest Editor
Pediatric Unit, IRCCS AOU, S. Orsola-Malpighi, 40138 Bologna, Italy
Interests: diabetes mellitus; clinical endocrinology; pediatric endocrinology; diabetes
Dr. Egidio Candela

E-Mail Website
Guest Editor Assistant
Pediatric Emergency Unit, Scientific Institute for Research and Healthcare (IRCCS), Sant’Orsola University Hospital, 40138 Bologna, Italy
Interests: pediatric endocrinology; metabolic disease; public health; food insecurity

Special Issue Information

Dear Colleagues,

It is with great pleasure that we invite you on behalf of Children to submit your research, reviews, clinical practice guidelines, case reports, and other article types in this Special Issue entitled “New Research Progress on Endocrine Disorders in Infants, Children, and Adolescents”. 

In the current Special Issue, we will focus on advancements made in the field of pediatric endocrinology, an exciting and constantly evolving field of study. In fact, we are confident that only through a constant collaboration among experts in this clinic area can progress be made in sectors such as disorders involving growth, pubertal development, sexual differentiation and development, thyroid and adrenal, pituitary tumors, calcium, phosphorus, vitamin D and bone metabolism, obesity, metabolic syndrome and others.

Our aim is to disseminate new basic and clinical knowledge useful for both specialists and pediatricians and we would especially like to give space to new original cases and modern approaches in patient diagnostic, management or innovative therapies

Prof. Dr. Stefano Zucchini
Guest Editor

Dr. Egidio Candela
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pediatric endocrinology
  • pediatric endocrine tumors
  • gland disorders (adrenal, pituitary, thyroid)
  • pediatric obesity
  • disorders of growth and growth factors
  • sexual dysfunctions
  • bone and mineral metabolism
  • pediatric thyroid disorders

Published Papers (1 paper)

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Research

14 pages, 1407 KiB  
Article
Exploring the Surge in Paediatric Type 2 Diabetes in an Inner-City London Centre—A Decade-Long Analysis of Incidence, Outcomes, and Transition
by Farah Abdelhameed, Anna Giuffrida, Ben Thorp, Myuri K. Moorthy and Evelien F. Gevers
Children 2024, 11(2), 173; https://doi.org/10.3390/children11020173 - 29 Jan 2024
Viewed by 902
Abstract
The rising prevalence of paediatric type 2 diabetes (T2D) is concerning, particularly with limited medical intervention despite evidence of accelerated disease progression. This study of a Barts Health NHS Trust cohort from 2008 to 2022 aims to elucidate the incidence, clinical outcomes, and [...] Read more.
The rising prevalence of paediatric type 2 diabetes (T2D) is concerning, particularly with limited medical intervention despite evidence of accelerated disease progression. This study of a Barts Health NHS Trust cohort from 2008 to 2022 aims to elucidate the incidence, clinical outcomes, and complications associated with paediatric T2D. A retrospective analysis utilising electronic and paper records identified 40 patients with T2D. The incidence doubled from 2.6/year in 2008–2013 to 5.4/year in 2014–2018. Sixty-eight percent exhibited co-morbidities, notably learning disabilities. At diagnosis, the mean BMI was 32.4 ± 6.71 kg/m2, with no gender-based disparity and no significant change over a two-year follow-up. The initial HbA1c was 75.2 ± 21.0 mmol/mol, decreasing to 55.0 ± 17.4 mmol/mol after three months (p = 0.001) and then rising to 63.0 ± 25.5 mmol/mol at one year (p = 0.07). While 22/37 patients achieved HbA1c < 48 mmol/mol, only 9 maintained this for a year. Several metabolic and cardiovascular complications were observed at diagnosis and follow-up, with no significant change in frequency. In 2022, 15 patients transitioned to adult services. HbA1c at transition was 74.7 ± 27.6 mmol/mol, showing no change one year post-transition (71.9 ± 26.9 mmol/mol, p = 0.34). This study highlights substantial therapeutic failure, with current management falling short in achieving a sustained reduction in BMI or HbA1c. Novel treatment approaches are needed to improve clinical outcomes and address the high burden of co-morbidities and complications. Full article
(This article belongs to the Special Issue New Research Progress on Endocrine Disorders in Infants, Children, and Adolescents)
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