Heart Failure in Acquired or Genetic Pediatric and Congenital Heart Disease

Dear Colleagues,

Heart failure in children spans a spectrum of etiologies including inherited cardiomyopathies, metabolic diseases, infectious, inflammatory or autoimmune diseases, nutritional deficiencies, and congenital heart disease. The age of presentation also spans a spectrum, from fetus to adulthood, in those with congenital heart disease. Thus, diagnostics and patient-specific treatment decisions can be very complex and need to be tailored to the individual circumstances of age, anatomy, and pathophysiology. While adult based goal-directed medical therapies are commonly utilized in pediatric heart failure and adults with congenital heart disease, as well as mechanical circulatory support and cardiac transplantation for end-stage heart disease, additional therapies have been and are being developed for those with other forms of cardiomyopathy, such as enzyme replacement therapy for some conditions and the presently off-label use of MEK inhibitors in RASopathy patients. Regarding children, novel treatments and genetic testing for cardiomyopathies bring up additional ethical issues compared to adults. Finally, addressing palliative care needs in pediatric heart failure is also an important topic. The goal of this Special Issue is to share clinical experiences, multidisciplinary approaches, and research to try to improve outcomes in pediatric and adult heart failure. Manuscripts of the following formats that address heart failure topics are welcome:

• Original, basic, and clinical articles;
• Prospective studies;
• Reviews.

Dr. Susan W. Denfield
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• heart failure
• cardiomyopathy
• congenital heart disease
• mechanical circulatory support
• heart transplantation
• palliative care