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Heart Failure in Acquired or Genetic Pediatric and Congenital Heart...
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Heart Failure in Acquired or Genetic Pediatric and Congenital Heart Disease

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Cardiology".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 2363

Special Issue Editor

Dr. Susan W. Denfield

E-Mail Website
Guest Editor
Division of Pediatric Cardiology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
Interests: heart failure; cardiac transplantation; restrictive cardiomyopathy; congenital and acquired pediatric heart disease

Special Issue Information

Dear Colleagues,

Heart failure in children spans a spectrum of etiologies including inherited cardiomyopathies, metabolic diseases, infectious, inflammatory or autoimmune diseases, nutritional deficiencies, and congenital heart disease. The age of presentation also spans a spectrum, from fetus to adulthood, in those with congenital heart disease. Thus, diagnostics and patient-specific treatment decisions can be very complex and need to be tailored to the individual circumstances of age, anatomy, and pathophysiology. While adult based goal-directed medical therapies are commonly utilized in pediatric heart failure and adults with congenital heart disease, as well as mechanical circulatory support and cardiac transplantation for end-stage heart disease, additional therapies have been and are being developed for those with other forms of cardiomyopathy, such as enzyme replacement therapy for some conditions and the presently off-label use of MEK inhibitors in RASopathy patients. Regarding children, novel treatments and genetic testing for cardiomyopathies bring up additional ethical issues compared to adults. Finally, addressing palliative care needs in pediatric heart failure is also an important topic. The goal of this Special Issue is to share clinical experiences, multidisciplinary approaches, and research to try to improve outcomes in pediatric and adult heart failure. Manuscripts of the following formats that address heart failure topics are welcome:

  • Original, basic, and clinical articles;
  • Prospective studies;
  • Reviews.

Dr. Susan W. Denfield
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • heart failure
  • cardiomyopathy
  • congenital heart disease
  • mechanical circulatory support
  • heart transplantation
  • palliative care

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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12 pages, 438 KiB  
Article
Assessing the Predictive Capabilities of Autoregressive Integrated Moving Average and Linear Regression Models for Acute Changes in Clinical and Selected Laboratory Parameters in Children After Cardiac Surgery in the ICU
by Sharmin Nahar Sharwardy, Hasan Sarwar, Mohammad Nurul Akhtar Hasan and Mohammad Zahidur Rahman
Children 2024, 11(11), 1312; https://doi.org/10.3390/children11111312 - 29 Oct 2024
Viewed by 1018
Abstract
(1) Background: The main objective of this research was to assess the clinical factors related to the condition of pediatric patients with congenital heart defects after they underwent intensive care unit surgery. The information was gathered from the Congenital Heart Disease Surgery Unit [...] Read more.
(1) Background: The main objective of this research was to assess the clinical factors related to the condition of pediatric patients with congenital heart defects after they underwent intensive care unit surgery. The information was gathered from the Congenital Heart Disease Surgery Unit at the National Heart Foundation Hospital and Research Institute in Dhaka, Bangladesh. We gathered and examined data from 288 ICU patients. Patients under the age of twelve who required more than a 24-h ICU stay were selected. (2) Methods: The dependent and independent variables were chosen in advance based on expert opinion. The relationships between these pre-specified ICU parameters were determined using the Pearson correlation model and assessed through linear regression and ARIMA modeling to predict subsequent acute changes in the patients’ ICU statuses. (3) Results: A statistically significant relationship (p value < 0.001) was found between CVP and BP (95% CI = 0.2113; 0.353 r = 0.2841249) and between PEEP and FiO2 (95% CI = 0.6992; 0.770 r = 0.7367744). Although the relationships between pH and PO2 were minor (95% CI = 0.161; 0.308 r = 0.2362575), they were statistically significant. The parameters considered statistically significant (p < 0.001) were chosen for forecasting. In this work, the linear regression model and the ARIMA model used the parameters BP, FiO2, and PO2 for prediction. We forecasted the patients’ statuses for the next hour. It was found that the ARIMA model had a lower error rate than the linear regression model. (4) Conclusions: This study helps identify the important parameters for predicting and monitoring patients’ statuses in the ICU, with the ultimate goal of providing physicians with an early warning system to anticipate deterioration in clinical and biochemical parameters. The ability to accurately forecast future patients’ conditions can enable proactive, targeted interventions, potentially improving outcomes and reducing the risk of adverse events. Full article
(This article belongs to the Special Issue Heart Failure in Acquired or Genetic Pediatric and Congenital Heart Disease)
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Review

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10 pages, 4932 KiB  
Review
Mechanical Circulatory Support in Congenital Heart Disease
by Áine Lynch and Aamir Jeewa
Children 2025, 12(3), 306; https://doi.org/10.3390/children12030306 - 28 Feb 2025
Viewed by 763
Abstract
As early survival outcomes have improved, heart failure in children with congenital heart disease (CHD) has become a growing problem. Primary care providers and pediatricians are thus encountering increasing numbers of children with or at-risk for heart failure. Despite medication, many of these [...] Read more.
As early survival outcomes have improved, heart failure in children with congenital heart disease (CHD) has become a growing problem. Primary care providers and pediatricians are thus encountering increasing numbers of children with or at-risk for heart failure. Despite medication, many of these children progress to end-stage heart failure and require heart transplant for long-term survival. Mechanical circulatory support (MCS) is increasingly utilized to support this cohort both acutely when recovery is anticipated, and as a bridge to transplant. Early referral to tertiary heart failure and MCS teams is key to facilitate timely institution of MCS and preserve end-organ function. MCS in children with CHD presents unique challenges due to patient size and complex intra- and extra-cardiac anatomy. Evaluations for MCS should take into account patient size, anatomy, end-organ function, and psychosocial supports. The form of MCS utilized is dependent on clinical urgency, patient size, and anatomy. We describe the evolving landscape of MCS in pediatric patients with CHD. Full article
(This article belongs to the Special Issue Heart Failure in Acquired or Genetic Pediatric and Congenital Heart Disease)
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