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Chemosensors
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Fluorescent Sensors for Disease Diagnosis and Therapy
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Fluorescent Sensors for Disease Diagnosis and Therapy

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "(Bio)chemical Sensing".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 11077

Special Issue Editors

Dr. Jianliang Shen

E-Mail Website
Guest Editor
Wenzhou Institute, University of Chinese Academy of Sciences, Zhejiang, China
Interests: Bioimaging, Theranostics, Nanomedicine, Drug delivey, Tissue engineering
Dr. Ji-Ting Hou

E-Mail Website
Guest Editor
1. School of Ophthalmology & Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
2. Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China
Interests: Fluroescent sensors; Bioimaging; Photosensitizer
Dr. Xiaojun He

E-Mail Website
Guest Editor
School of Ophthalmology & Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
Interests: Fluroescent sensors; Bioimaging; Antibacterial therapy

Special Issue Information

Dear Colleagues,

Modern theranostics requires personal and precise insight into the pathology of various diseases, which can not be fulfilled by a singally clinical diagnostic tools such as MRI, CT, and PET. In the last several decades, fluorescence imaging has shown tremendous advantages in disease diagnosis, such as its high sensitivity, non-invasive and real-time imaging ability, superb temporal and spatial resolution, and easy operation. Several fluorescent dyes have been utilized clinically. For example, fluorescein sodium is widely used for diagnosis of ophthalmic diseases. The use of fluorescent imaging techniques paves the way for precise diseases diagnosis and further therapy.

On one hand, fluorescence imaging for disease diagnosis is achieved by the interaction between a fluorescent sensor and a disease biomarker. After interaction, changes in fluorescence signals will be produced, thus providing the information on disease onset and development. The biomarkers can be any substances that are abnormally expressed in certain diseases, like enzymes, metal ions, and microenvironments. On the other hand, fluorescence imaging-guided therapy, including photodynamic therapy and photothermal therapy are of great research interest.

This Special Issue of Chemosensors focuses on the design and development of fluorescent sensors for disease diagnosis and therapy. These sensors can be small organic molecules, polymers, and nanomaterials. Techniques such as fluorescence microscopy, fluorescence life-time imaging microscopy, and super-resolution fluorescence microscopy can be involved. We look forward to receiving papers on the latest developments in this field.

Dr. Jianliang Shen
Dr. Ji-Ting Hou
Dr. Xiaojun He
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Fluorescent sensors
  • Fluorescence detection
  • Sensing materials
  • Biomedical imaging
  • Disease biomarker
  • Disease models
  • Disease diagnosis
  • Disease Therapy

Published Papers (6 papers)

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Research

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11 pages, 3290 KiB  
Article
Carboxy Bodipy-Based Fast Trigger Fluorescent Probe for Imaging Endogenous Hypochlorous Acid
by Hao Zhang, Qincong Feng, Ji-Ting Hou, Zhipeng Li and Jianliang Shen
Chemosensors 2023, 11(1), 26; https://doi.org/10.3390/chemosensors11010026 - 28 Dec 2022
Cited by 1 | Viewed by 1349
Abstract
Although hypochlorous acid (HClO/ClO−) is regarded as a harmful reactive oxygen species (ROS) in cells, it plays an essential role in many physiological and pathological processes, such as an innate immunity and metabolic balance. In this paper, we developed a new [...] Read more.
Although hypochlorous acid (HClO/ClO−) is regarded as a harmful reactive oxygen species (ROS) in cells, it plays an essential role in many physiological and pathological processes, such as an innate immunity and metabolic balance. In this paper, we developed a new carboxy Bodipy-based probe for rapid, sensitive, and specific monitoring of ClO−. Bp-S produces bright fluorescent Bp-COOH based on the selective recognition of ClO− to thiocarbamate groups. Bp-S exhibits high selectivity, high sensitivity, and high resistance to photobleaching in the recognition of ClO−. Fluorescence imaging of this probe in Hela cells and RAW264.7 cells also successfully detected changes in exogenous/endogenous ClO−, respectively, suggesting that Bp-S has high potential for future disease diagnosis and research. Full article
(This article belongs to the Special Issue Fluorescent Sensors for Disease Diagnosis and Therapy)
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16 pages, 9708 KiB  
Article
Enhanced Visible Light Absorption and Photophysical Features of Novel Isomeric Magnesium Phthalocyaninates with Cyanophenoxy Substitution
by Dmitry Erzunov, Svetlana Tonkova, Anastasia Belikova and Arthur Vashurin
Chemosensors 2022, 10(12), 503; https://doi.org/10.3390/chemosensors10120503 - 28 Nov 2022
Cited by 2 | Viewed by 1154
Abstract
Novel metal-free and Mg(II) [3/4-(3,4-dicyanophenoxy)phenoxy]-substituted phthalocyanines were obtained and characterized using NMR, IR, UV-vis spectroscopy, and mass spectrometry. This substitution provided compounds with good solubility in organic media, and thus their spectroscopic and fluorescent properties were studied. The formation of the investigated phthalocyanine [...] Read more.
Novel metal-free and Mg(II) [3/4-(3,4-dicyanophenoxy)phenoxy]-substituted phthalocyanines were obtained and characterized using NMR, IR, UV-vis spectroscopy, and mass spectrometry. This substitution provided compounds with good solubility in organic media, and thus their spectroscopic and fluorescent properties were studied. The formation of the investigated phthalocyanine complexes with central magnesium ions led to the stabilization of macrocyclic molecules in solution, preventing aggregation through specific and universal solvation. From meta-substitution to para-substitution, insignificant spectroscopic changes were observed. The complexes exhibited higher values of molar light absorption coefficients and fluorescence quantum yields (up to 55%) compared to ligands. The efficiency of both the fluorescence-quenching and singlet oxygen generation processes in the case of magnesium [3/4-(3,4-dicyanophenoxy)phenoxy]phthalocyaninates was found to exceed that of the unsubstituted zinc phthalocyaninate, which suggests the potential applicability of these compounds as PDT sensitizers. Full article
(This article belongs to the Special Issue Fluorescent Sensors for Disease Diagnosis and Therapy)
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17 pages, 4714 KiB  
Article
Box–Behnken Design Optimizing Sugarcane Bagasse-Based Nitrogen-Doped Carbon Quantum Dots Preparation and Application in Ferric Ion Detection
by Shouxiang Sun, Shuai Guo, Qin Qin, Yexin Liao, Mei Li and Fangkai Du
Chemosensors 2022, 10(11), 453; https://doi.org/10.3390/chemosensors10110453 - 01 Nov 2022
Cited by 4 | Viewed by 1680
Abstract
Sugarcane bagasse is an abundant biomass waste and a promising carbon source for preparing carbon-based materials such as carbon quantum dots (CQDs). Low quantum yield is a major problem for sugarcane bagasse-based carbon quantum dots. Heteroatom-doped modification is an efficient approach to improve [...] Read more.
Sugarcane bagasse is an abundant biomass waste and a promising carbon source for preparing carbon-based materials such as carbon quantum dots (CQDs). Low quantum yield is a major problem for sugarcane bagasse-based carbon quantum dots. Heteroatom-doped modification is an efficient approach to improve the quantum yield. A facile hydrothermal carbonization method was applied to synthesize the nitrogen-doped carbon quantum dot N-CQDs using urea as the nitrogen source. The synthetic procedure was determined by the single-factor experiments and the response surface methodology (RSM) based on Box–Behnken design (BBD). The optical properties of optimized N-CQD-13 were more excellent than those of undoped CQD. Higher quantum yields (both absolute and relative) were observed in N-CQD-13. Additionally, N-CQD-13 exhibited high stability for long-time storage and excellent pH tolerance in aqueous solutions. N-CQD-13 were applied to detect Fe3+ in aqueous solutions with a low detection limit of 0.44 μM. The fluorescence lifetime decay of the N-CQD-13 solutions untreated and treated with Fe3+ indicated the probable involvement of a dynamic fluorescence-quenching mechanism. Thus, this work explored a reliable method for the high-quality utilization of bagasse. Full article
(This article belongs to the Special Issue Fluorescent Sensors for Disease Diagnosis and Therapy)
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13 pages, 27057 KiB  
Article
Copper-Induced Fluorescence Quenching in a Bis[2-(2′-hydroxyphenyl)benzoxazole]pyridinium Derivative for Quantification of Cu2+ in Solution
by Buddhima U. Rajapakshe, Yonghao Li, Brian Corbin, Kaveesha J. Wijesinghe, Yi Pang and Chathura S. Abeywickrama
Chemosensors 2022, 10(10), 382; https://doi.org/10.3390/chemosensors10100382 - 22 Sep 2022
Cited by 3 | Viewed by 1775
Abstract
Accurate determination of Cu2+ in solution is crucial for preventing several disease conditions. Spectroscopy-based techniques for metal ion detection are promising methods due to their excellent sensitivity and rapid response time. In this work, we are reporting a newly synthesized 2-(2′-Hydroxyphenyl) benzoxazole-based [...] Read more.
Accurate determination of Cu2+ in solution is crucial for preventing several disease conditions. Spectroscopy-based techniques for metal ion detection are promising methods due to their excellent sensitivity and rapid response time. In this work, we are reporting a newly synthesized 2-(2′-Hydroxyphenyl) benzoxazole-based compound, probe 2, by incorporating a vinyl pyridinium segment into the bis(HBO) 4 system. Probe 2 exhibited excellent specificity toward Cu2+ in solution. The ratiometric absorbance (λ440/λ370) and the quenching of fluorescence at λem ≈585 nm exhibited an excellent linear correlation. The formation of the 2-Cu complex can be utilized as a highly sensitive spectroscopic method for the detection of Cu2+ in solution with a detection limit of 0.15 µM. In addition, Cu2+-induced fluorescence quenching in probe 2 occurs mainly via a static quenching mechanism by forming a 2-Cu complex, and the stability constant for the 2-Cu complex was calculated based on spectroscopic measurements. Full article
(This article belongs to the Special Issue Fluorescent Sensors for Disease Diagnosis and Therapy)
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12 pages, 3692 KiB  
Communication
A Ratiometric Selective Fluorescent Probe Derived from Pyrene for Cu2+ Detection
by Chunwei Yu, Mei Yang, Shuhua Cui, Yuxiang Ji and Jun Zhang
Chemosensors 2022, 10(6), 207; https://doi.org/10.3390/chemosensors10060207 - 31 May 2022
Cited by 4 | Viewed by 2134
Abstract
A novel ratiometric Cu2+-selective probe was rationally constructed based on pyrene derivative. Compared to other tested metal ions, the probe presented the selective recognition for Cu2+ which could be detected by a significant turn-on fluorescent response at 393 nm and [...] Read more.
A novel ratiometric Cu2+-selective probe was rationally constructed based on pyrene derivative. Compared to other tested metal ions, the probe presented the selective recognition for Cu2+ which could be detected by a significant turn-on fluorescent response at 393 nm and 415 nm. Under the optimized conditions, a detection limit of 0.16 μM Cu2+ in aqueous media was found. Besides this, a 1:1 metal–ligand complex was confirmed by MS spectra and Job’s plot experiment, and the binding mode was also studied by 1H NMR experiment. Meanwhile, the fluorescence imaging in living cells was performed to detect Cu2+ with satisfactory results. Full article
(This article belongs to the Special Issue Fluorescent Sensors for Disease Diagnosis and Therapy)
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Review

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30 pages, 11619 KiB  
Review
Recent Progress in Fluorescent Probes for Diabetes Visualization and Drug Therapy
by Tong-Tong Jia, Yashan Li and Huawei Niu
Chemosensors 2022, 10(7), 280; https://doi.org/10.3390/chemosensors10070280 - 14 Jul 2022
Cited by 9 | Viewed by 2296
Abstract
Diabetes has become one of the most prevalent endocrine and metabolic diseases that threaten human health, and it is accompanied by serious complications. Therefore, it is vital and pressing to develop novel strategies or tools for prewarning and therapy of diabetes and its [...] Read more.
Diabetes has become one of the most prevalent endocrine and metabolic diseases that threaten human health, and it is accompanied by serious complications. Therefore, it is vital and pressing to develop novel strategies or tools for prewarning and therapy of diabetes and its complications. Fluorescent probes have been widely applied in the detection of diabetes due to the fact of their attractive advantages. In this report, we comprehensively summarize the recent progress and development of fluorescent probes in detecting the changes in the various biomolecules in diabetes and its complications. We also discuss the design of fluorescent probes for monitoring diabetes in detail. We expect this review will provide new ideas for the development of fluorescent probes suitable for the prewarning and therapy of diabetes in future clinical transformation and application. Full article
(This article belongs to the Special Issue Fluorescent Sensors for Disease Diagnosis and Therapy)
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