Molecularly Imprinted Polymer (MIP) Sensors

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Materials for Chemical Sensing".

Deadline for manuscript submissions: 30 December 2025 | Viewed by 523

Special Issue Editor

Department of Chemistry, National University of Singapore, Singapore 117543, Singapore
Interests: molecularly imprinted polymers (MIPs); sensors; sensor automation; quartz crystal microbalance; catalysis; wastewater and solid waste treatment; environmental chemistry; new energy sources; low-carbon technologies
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Special Issue Information

Dear Colleagues,

Molecularly imprinted polymers (MIPs) are synthetic materials engineered to have highly specific recognition sites for a target molecule (template). Some MIPs are often referred to as "synthetic antibodies" due to their selectivity and ability to recognize specific molecules, similar to natural antibodies or enzymes. Tailored binding sites mimic the size, shape, and functional groups of the target molecule. Hence, MIPs can recognize a wide range of targets, including small organic molecules, peptides, proteins, and ions. They can be regenerated and reused without significant loss of performance. MIPs also exhibit high thermal, chemical, and mechanical stability compared to natural recognition systems. MIPs have found many applications in sensors, separation, purification, environmental monitoring, drug delivery, catalysis, etc. However, MIP technology also faces certain challenges: (1) Residual template molecules may contaminate the binding sites. (2) Binding of non-target molecules can reduce selectivity. (3) Variability in the structure of binding sites can affect performance. Over the past 5 years, there have been 4,393 publications on the topic of MIP sensors. In this Special Issue, we welcome articles on the synthesis, characterization, properties, mechanisms, and applications of MIP sensors. We look forward to your submissions.

Dr. Xuanhao Lin
Guest Editor

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Keywords

  • molecularly imprinted polymers
  • polymer nanoparticles
  • electrochemical sensors

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Published Papers (1 paper)

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Research

13 pages, 1316 KiB  
Article
Molecularly Imprinted Electrochemical Sensor Electrodes Based on Poly-Pyrrole for Sensitive Detection of Morphine in Wastewater
by Pranaya Charkravarthula and Amos Mugweru
Chemosensors 2025, 13(8), 284; https://doi.org/10.3390/chemosensors13080284 - 4 Aug 2025
Viewed by 354
Abstract
Morphine is an opioid extracted from the poppy plant and highly effective for moderate to severe pain management. Development of techniques to measure the concentration of this highly addictive drug in various matrices is very important. This work was aimed at the development [...] Read more.
Morphine is an opioid extracted from the poppy plant and highly effective for moderate to severe pain management. Development of techniques to measure the concentration of this highly addictive drug in various matrices is very important. This work was aimed at the development of a sensitive electrochemical method for detection of morphine in wastewater. Molecularly imprinted (MIP) electrodes were made by the electro-polymerization process using pyrrole as a monomer. Electro-polymerization was performed on glassy carbon electrodes in the presence of morphine before the extraction of the entrapped morphine molecules. Various techniques were employed to monitor the polymerization and response of the fabricated electrodes toward morphine. These techniques included Fourier transform infrared spectroscopy (FTIR), cyclic voltammetry (CV), square wave voltammetry (SWV), and electrochemical impedance spectroscopy (EIS). The morphine concentration was determined using SWV and CV by measuring the change in the redox peak current of [Fe(CN)6]−3/−4. These MIP electrode sensors were used to analyze morphine concentrations between 0 and 80.0 nM solution. The SWV showed a wider linear response region than CV. The detection limit using SWV was found to be 1.9 nM, while using CV, the detection limit was 2.75 nM. This MIP electrode sensor exhibited specificity when other closely related molecules were included and hence has potential as a cheap alternative technique for analysis of morphine. Full article
(This article belongs to the Special Issue Molecularly Imprinted Polymer (MIP) Sensors)
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