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Chemosensors
Special Issues
Electrochemical Sensors and Biosensors: Recent Advances and Future Challenges
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Electrochemical Sensors and Biosensors: Recent Advances and Future Challenges

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Electrochemical Devices and Sensors".

Deadline for manuscript submissions: 30 October 2026 | Viewed by 5536

Special Issue Editor

Dr. Ancuța Dinu

E-Mail Website
Guest Editor
Research Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University of Galati, 47 Domneasca Street, 800201 Galați, Romania
Interests: voltammetry technique; electrochemical sensors and biosensors; screen-printed electrodes; conductive polymers; pharmaceutical compounds

Special Issue Information

Dear Colleagues,

Electrochemical sensors and biosensors are versatile tools widely used across various fields, including chemistry, biology, pharmacy, medicine, industry, and environmental monitoring. These devices are known for their reliability, allowing for the rapid, accurate, and cost-effective detection of a wide range of analytes.

This Special Issue entitled "Electrochemical Sensors and Biosensors: Recent Advances and Future Challenges" aims to highlight the progress and challenges that electrochemical detection devices raise from the perspective of using materials, such as polymers, that have advanced and beneficial properties for modifying the electrode surface. This Special Issue aims to present the latest research in the fields of electrochemical sensors and biosensors, as well as to introduce advanced methods and strategies designed to enhance performance through improved reproducibility, selectivity, and sensitivity.

We invite you to submit original articles, review papers, or short communications for this Special Issue, focusing on the latest developments in the detection of pharmaceutical compounds, medical diagnostics, environmental monitoring, and food product safety. We encourage the use of electrochemical sensors and biosensors that incorporate conducting polymers, nanomaterials, and enzyme materials. By compiling innovative and current research in this Special Issue, we aim to inspire and stimulate the scientific community, leading to meaningful advancements in the field of electrochemical sensors and biosensors.

We look forward to receiving your contributions.

Dr. Ancuța Dinu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • electrochemical sensors
  • enzymatic biosensors
  • conductive polymers
  • amino acids
  • heavy metal detection
  • pharmaceutical compounds
  • drug and medico-dignostic testing

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Published Papers (4 papers)

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Research

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17 pages, 4082 KB  
Article
Development of a Sensitive and Cost-Effective MWCNTs/CCE Sensor for Electrochemical Determination of Prednisolone in Pharmaceuticals and Blood Serum
by Maksim V. Lipskikh, Elena I. Korotkova, Alina V. Erkovich, Margarita S. Mamina, Muhammad Saqib, Olga I. Lipskikh and Pradip K. Kar
Chemosensors 2025, 13(12), 404; https://doi.org/10.3390/chemosensors13120404 - 21 Nov 2025
Cited by 6 | Viewed by 1027 | Correction
Abstract
A sensitive and cost-effective voltammetric sensor using a carbon-containing electrode (CCE) with a renewable surface modified with multi-walled carbon nanotubes (MWCNTs) was developed for the determination of prednisolone in pharmaceuticals and blood serum. The morphological effects of the functionalization process on the MWCNTs [...] Read more.
A sensitive and cost-effective voltammetric sensor using a carbon-containing electrode (CCE) with a renewable surface modified with multi-walled carbon nanotubes (MWCNTs) was developed for the determination of prednisolone in pharmaceuticals and blood serum. The morphological effects of the functionalization process on the MWCNTs were investigated by transmission electron microscopy (TEM). Analysis of the micrographs indicated that the functionalized nanotubes exhibited a higher density of surface defects and a reduced tendency to form bundles compared to their pristine counterparts. Energy dispersive spectrometry (EDS) confirmed that residual iron particles were removed from the MWCNTs during acid functionalization, demonstrating their intrinsic conductivity. The MWCNTs/CCE was characterized by electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The electrochemical behavior of prednisolone in Britton–Robinson buffer at the MWCNTs/CCE was investigated by linear sweep cathodic voltammetry, while the quantitative determination was performed by differential pulse voltammetry (DPV). Under optimal conditions, the sensor exhibited a linear concentration range from 0.04 to 0.6 μM with a detection limit of 8 nM. The proposed method was successfully applied in the determination of prednisolone in pharmaceutical formulations and blood serum. Full article
(This article belongs to the Special Issue Electrochemical Sensors and Biosensors: Recent Advances and Future Challenges)
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20 pages, 3477 KB  
Article
Computational and Theoretical Methods for Mass-Transport Analysis in 3D-Printed Milli Fluidic Electrochemical Devices with Channel Band Electrodes
by Jesús E. Contreras-Naranjo, Victor H. Perez-Gonzalez, Marco A. Mata-Gómez and Oscar Aguilar
Chemosensors 2025, 13(11), 401; https://doi.org/10.3390/chemosensors13110401 - 19 Nov 2025
Viewed by 1185
Abstract
Available models for mass transport in microfluidic electrochemical sensors fall short in capturing critical features of millimeter-scale devices 3D-printed using fused deposition modeling, including inherent porosity and non-flat electrode geometries, thereby reducing their predictive power and transferability. Meanwhile, growing interest in low-cost and [...] Read more.
Available models for mass transport in microfluidic electrochemical sensors fall short in capturing critical features of millimeter-scale devices 3D-printed using fused deposition modeling, including inherent porosity and non-flat electrode geometries, thereby reducing their predictive power and transferability. Meanwhile, growing interest in low-cost and accessible fabrication methodologies has driven the quantitative use of these devices without first understanding the effects of such structural features on current responses. Here, the quantitative electrochemical performance of millimeter-scale 3D-printed devices with channel band electrodes is studied through computational and theoretical methods aimed at understanding their fundamental behavior. Simulations and dimensionless analysis reveal the influence of electrode shape and porosity on current responses under laminar flow. An adjusted Levich model is proposed to incorporate non-flat electrode geometries, while two new analytical models—general and transition-specific—predict currents through all mass transport regimes (convection, diffusion, and transition) that can simultaneously emerge due to porosity effects. Moreover, we introduce a low-cost “print–pause–print” fabrication strategy for such systems, employing a desktop 3D printer and 3D pen, which allows electrode integration and activation through polishing and “in-channel” electrochemical treatment. These advances facilitate developing next-generation 3D-printed milli fluidic electrochemical platforms with improved performance and scalability. Full article
(This article belongs to the Special Issue Electrochemical Sensors and Biosensors: Recent Advances and Future Challenges)
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Review

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30 pages, 3133 KB  
Review
Functional Solid–Liquid Interfaces for Electrochemical Blood Glucose Sensing: New Insights and Future Prospects
by Zarish Maqbool, Nadeem Raza, Azra Hayat, Mostafa E. Salem and Muhammad Faizan Nazar
Chemosensors 2025, 13(11), 385; https://doi.org/10.3390/chemosensors13110385 - 3 Nov 2025
Cited by 1 | Viewed by 2219
Abstract
Blood glucose monitoring is essential for the treatment of diabetes, a chronic disease that affects millions of people worldwide. Non-electrochemical blood glucose sensors often lack sensitivity and selectivity, especially in complex biological fluids, and are not suitable for wearable point-of-care devices. Electrochemical blood [...] Read more.
Blood glucose monitoring is essential for the treatment of diabetes, a chronic disease that affects millions of people worldwide. Non-electrochemical blood glucose sensors often lack sensitivity and selectivity, especially in complex biological fluids, and are not suitable for wearable point-of-care devices. Electrochemical blood glucose sensors, on the other hand, are easy to handle, inexpensive, and offer high sensitivity and selectivity even in the presence of interfering molecules. They can also be seamlessly integrated into wearable devices. This review explores the key blood glucose technologies, emphasizing the operating principle and classification of electrochemical glucose sensors. It also highlights the role of functional solid–liquid interfaces in optimizing sensor performance. Recent developments in solid–liquid interfacial materials, including metal-based, metal oxide-based, carbon-based, nanoparticle-based, conductive polymer, and graphene-based interfaces, are systematically analyzed for their sensing potential. Furthermore, this review highlights existing patents, the evolving market landscape, and data from clinical studies that bridge the gap between laboratory research and commercial application. Finally, we present future perspectives and highlight the need for next-generation wearable and enzyme-free glucose sensors for continuous and non-invasive glucose monitoring. Full article
(This article belongs to the Special Issue Electrochemical Sensors and Biosensors: Recent Advances and Future Challenges)
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1 pages, 130 KB  
Correction
Correction: Lipskikh et al. Development of a Sensitive and Cost-Effective MWCNTs/CCE Sensor for Electrochemical Determination of Prednisolone in Pharmaceuticals and Blood Serum. Chemosensors 2025, 13, 404
by Maksim V. Lipskikh, Elena I. Korotkova, Alina V. Erkovich, Margarita S. Mamina, Muhammad Saqib, Olga I. Lipskikh and Pradip K. Kar
Chemosensors 2026, 14(3), 63; https://doi.org/10.3390/chemosensors14030063 - 6 Mar 2026
Viewed by 419
Abstract
The blood serum that was used in the original publication [...] Full article
(This article belongs to the Special Issue Electrochemical Sensors and Biosensors: Recent Advances and Future Challenges)
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