Special Issue "Synthesis and Catalytic Applications of S-, Se- and Te-Containing Compounds: Recent Advances in Organic Synthesis"

A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Catalysis in Organic and Polymer Chemistry".

Deadline for manuscript submissions: 31 October 2022 | Viewed by 2489

Special Issue Editors

Prof. Dr. Antonella Capperucci
E-Mail Website
Guest Editor
Dipartimento di Chimica "Ugo Schiff" Università degli Studi di Firenze, Via della Lastruccia, 13 – 50019 Sesto Fiorentino (Firenze), Italy
Interests: synthesis and reactivity of organosulfur, organoselenium and organotellurium compounds, also mediated by organosilanes; study of their properties as new antioxidants and enzyme modulators; synthesis and functionalization of heterocyclic compounds
Dr. Damiano Tanini
E-Mail Website
Guest Editor
Dipartimento di Chimica “Ugo Schiff”, Università degli Studi di Firenze, Via della Lastruccia, 13, 50019 Sesto Fiorentino (Firenze), Italy
Interests: development of new synthetic methodologies towards sulfur-, selenium-, and tellurium-containing cyclic and acyclic organic molecules; study of alternative and environmentally routes to access and functionalize synthetically and biologically valuable organic compounds; design and synthesis of novel chalcogen-containing catalytic antioxidants

Special Issue Information

Dear Colleagues,

Chalcogen-containing organic molecules (S, Se, Te) occupy a relevant position in the chemical sciences, finding a steadily growing application in organic synthesis, catalysis, materials science, and polymer chemistry. Furthermore, such molecules play an increasingly important role in biology and in medicinal chemistry. For example, a number of organoselenium and organotellurium compounds have exhibited remarkable catalytic antioxidant activity. In this scenario, owing to their unique properties, organochalcogenides have in recent decades attracted a great deal of interest among organic chemists, biologists, and medicinal chemists, as proven by the growing number of studies focusing on these topics.

The possibility to introduce a variety of functional groups and the opportunity to access a plethora of highly diversified chalcogen-containing structures are of paramount importance in order to successfully develop new synthetically and biologically valuable systems. Therefore, the development of new synthetic methodologies towards these classes of compounds, as well as the study of their environmentally friendly synthetic and catalytic applications, represent one of the more fascinating challenges ahead in this field.

This Special Issue will be focusing on experimental, theoretical, and applicative studies involving sulfur-, selenium-, and tellurium-containing molecules. Particular emphasis will be devoted on recent advances in the synthesis of chalcogenated systems and in the study of their catalytic properties. Applications in the field of organic transformations, sustainable processes, material science, biology, and medicinal chemistry will be covered.

Prof. Dr. Antonella Capperucci
Dr. Damiano Tanini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sulfur
  • selenium
  • tellurium
  • synthetic methodologies
  • green chemistry
  • sustainable processes
  • glutathione peroxidase-like systems
  • enzyme modulators and mimics
  • polymers and materials
  • density functional theory
  • spectroscopic properties

Published Papers (2 papers)

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Review

Review
Recent Advances in the Synthesis of Isothiocyanates Using Elemental Sulfur
Catalysts 2021, 11(9), 1081; https://doi.org/10.3390/catal11091081 - 08 Sep 2021
Cited by 1 | Viewed by 777
Abstract
Isothiocyanates (ITCs) are biologically active molecules found in several natural products and pharmaceutical ingredients. Moreover, due to their high and versatile reactivity, they are widely used as intermediates in organic synthesis. This review considers the best practices for the synthesis of ITCs using [...] Read more.
Isothiocyanates (ITCs) are biologically active molecules found in several natural products and pharmaceutical ingredients. Moreover, due to their high and versatile reactivity, they are widely used as intermediates in organic synthesis. This review considers the best practices for the synthesis of ITCs using elemental sulfur, highlighting recent developments. First, we summarize the in situ generation of thiocarbonyl surrogates followed by their transformation in the presence of primary amines leading to ITCs. Second, carbenes and amines afford isocyanides, and the further reaction of this species with sulfur readily generates ITCs under thermal, catalytic or basic conditions. Additionally, we also reveal that in the catalyst-free reaction of isocyanides and sulfur, two—until this time overlooked and not investigated—different mechanistic pathways exist. Full article
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Review
Carbonic Anhydrases: Versatile and Useful Biocatalysts in Chemistry and Biochemistry
Catalysts 2020, 10(9), 1008; https://doi.org/10.3390/catal10091008 - 03 Sep 2020
Cited by 10 | Viewed by 1238
Abstract
Metalloenzymes such as the carbonic anhydrases (CAs, EC 4.2.1.1) possess highly specialized active sites that promote fast reaction rates and high substrate selectivity for the physiologic reaction that they catalyze, hydration of CO2 to bicarbonate and a proton. Among the eight genetic [...] Read more.
Metalloenzymes such as the carbonic anhydrases (CAs, EC 4.2.1.1) possess highly specialized active sites that promote fast reaction rates and high substrate selectivity for the physiologic reaction that they catalyze, hydration of CO2 to bicarbonate and a proton. Among the eight genetic CA macrofamilies, α-CAs possess rather spacious active sites and show catalytic promiscuity, being esterases with many types of esters, but also acting on diverse small molecules such as cyanamide, carbonyl sulfide (COS), CS2, etc. Although artificial CAs have been developed with the intent to efficiently catalyse non-biologically related chemical transformations with high control of stereoselectivity, the activities of these enzymes were much lower when compared to natural CAs. Here, we report an overview on the catalytic activities of α-CAs as well as of enzymes which were mutated or artificially designed by incorporation of transition metal ions. In particular, the distinct catalytic mechanisms of the reductase, oxidase and metatheses-ase such as de novo designed CAs are discussed. Full article
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Carbonic anhydrase: A versatile and useful biocatalyst tool in chemistry and biochemistry fields
Authors: Andrea Angeli; Fabrizio Carta; Claudiu T. Supuran
Affiliation: Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy: [email protected] (C.T.S.)
Abstract: Metalloenzymes such as the Carbonic Anhydrases (CAs, EC 4.2.1.1) possess highly specialized active sites that promote fast reaction rates and high substrate selectivity. Among the 8 genetic CA macrofamilies, the α-isoforms possess rather spacious active sites and show a certain catalytic promiscuity. Although artificial CAs have been developed with the intent to efficiently catalyse non-biologically related chemical transformations with high control of stereoselectivity, the activities of these enzymes were much lower when compared to natural CAs. Here, we report an overview on catalytic activities of natural CAs as well as enzymes which were mutated or artificially designed. In particular, the distinct catalytic mechanism of hydratase, reductase and oxidase proprieties are reviewed.

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