Journal Description
ChemEngineering
ChemEngineering
is an international, peer-reviewed, open access journal on the science and technology of chemical engineering, published bimonthly online by MDPI.
- Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
- High Visibility: indexed within Scopus, ESCI (Web of Science), Inspec, CAPlus / SciFinder, and other databases.
- Journal Rank: JCR - Q2 (Engineering, Chemical) / CiteScore - Q1 (General Engineering )
- Rapid Publication: manuscripts are peer-reviewed and a first decision is provided to authors approximately 29.6 days after submission; acceptance to publication is undertaken in 5.7 days (median values for papers published in this journal in the first half of 2025).
- Recognition of Reviewers: reviewers who provide timely, thorough peer-review reports receive vouchers entitling them to a discount on the APC of their next publication in any MDPI journal, in appreciation of the work done.
Impact Factor:
3.4 (2024);
5-Year Impact Factor:
3.1 (2024)
Latest Articles
A Study on the Effects of Solvent and Temperature on 2-Amino-7-Nitro-Fluorene (ANF) Using Synchronous Fluorescence
ChemEngineering 2025, 9(4), 69; https://doi.org/10.3390/chemengineering9040069 (registering DOI) - 27 Jun 2025
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Synchronous fluorescence spectra are presented to investigate solute–solvent interactions in liquids. To this end, the spectra of 2-amino-7-nitro-fluorene (ANF) in six different solvents—acetic anhydride, acetone, acetonitrile, benzene, chlorobenzene, and ethyl acetate—are presented. The study also examines ANF’s synchronous fluorescence signals at five temperatures
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Synchronous fluorescence spectra are presented to investigate solute–solvent interactions in liquids. To this end, the spectra of 2-amino-7-nitro-fluorene (ANF) in six different solvents—acetic anhydride, acetone, acetonitrile, benzene, chlorobenzene, and ethyl acetate—are presented. The study also examines ANF’s synchronous fluorescence signals at five temperatures from 25 °C to 5 °C, providing a comprehensive analysis of its fluorescence characteristics in different environments and temperatures. An ANF sample dissolved in benzene at 5 °C produced a synchronous band with the largest intensity and smallest frequency shift. The results show that higher-intensity peaks are obtained at lower temperatures with solvents with a small dipole moment and dielectric constant. This suggest that the best conditions to detect ANF and similar molecules at very low concentrations are with non-polar solvents at low temperatures.
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Open AccessArticle
Combustion Air Humidifier for a Biomass Boiler with Flue Gas Condensation
by
Jan Havlík and Tomáš Dlouhý
ChemEngineering 2025, 9(4), 68; https://doi.org/10.3390/chemengineering9040068 - 25 Jun 2025
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This paper deals with combustion air humidification for application with a biomass boiler and a spray flue gas condenser. The use of a combustion air humidifier increases the dew point temperature of the flue gas, thereby increasing the potential for heat recovery in
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This paper deals with combustion air humidification for application with a biomass boiler and a spray flue gas condenser. The use of a combustion air humidifier increases the dew point temperature of the flue gas, thereby increasing the potential for heat recovery in the flue gas condenser and increasing the amount of heat supplied to the thermal system. The air humidification process in a counter current spray humidifier was experimentally analysed under conditions corresponding to the use before a biomass boiler with a flue gas condenser. For air heating and humidification, temperature factor values of up to 0.90 can be obtained; this value is mainly influenced by the ratio of the spray water and humidified air flow rates. The volumetric heat transfer coefficient is significantly affected by the humidified air velocity, although this velocity is negligible compared to the counter current spray water velocity. The volumetric heat transfer coefficient reaches higher values at higher spray water temperatures and therefore higher air heating. The whole process is also affected by the saturation of the incoming air, where the dew point temperature of the air drawn in from the surroundings is lower than its temperature. These results can be used as basic information for the design of combustion air humidifiers, for the selection of their operating parameters, and for a basic balancing of the energy contribution of the combustion air humidifier before a more detailed design of the whole system.
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Open AccessArticle
New Approach to the Combined Removal of NOx and SO2 for Circulating Fluidized Beds
by
Chao Wang and Qinggang Lyu
ChemEngineering 2025, 9(4), 67; https://doi.org/10.3390/chemengineering9040067 - 25 Jun 2025
Abstract
Post-combustion technology is a new kind of low-nitrogen combustion technology. To achieve the combined removal of nitrogen oxides (NOx) and sulfur dioxide (SO2) emissions, the post-combustion technology combined with the sorbent injection in the furnace and post-combustion chamber is
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Post-combustion technology is a new kind of low-nitrogen combustion technology. To achieve the combined removal of nitrogen oxides (NOx) and sulfur dioxide (SO2) emissions, the post-combustion technology combined with the sorbent injection in the furnace and post-combustion chamber is proposed. Experiments investigating the effects of the sorbent addition in a post-combustion chamber and post-combustion air arrangement on NOx and SO2 emissions were conducted in a 0.1 MWth circulating fluidized bed test platform. In addition, a comparative analysis of the NOx and SO2 emissions under both combined removal methods was also performed. The results indicated that adding sorbent to the post-combustion chamber can reduce SO2 emissions, but further increasing the amount of sorbent will not significantly improve the desulfurization effect. The injection position of the post-combustion air will affect the emissions of NOx and SO2 in the flue gas. When the three-stage distribution of post-combustion air is adopted, the further back the third nozzle is distributed, the lower the temperature in the post-combustion chamber, which is beneficial to the control of NOx and SO2 emissions. Compared with the conventional combined removal method, the NOx emissions were significantly reduced under the new combined removal method. Through secondary desulfurization in the furnace and post-combustion chamber, oxygen-deficient combustion in the furnace can achieve the combined removal of NOx and SO2.
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(This article belongs to the Special Issue Fuel Engineering and Technologies)
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Open AccessArticle
Anode-Supported SOFCs with a Bi2O3-Doped NiO–ScSZ Anode and ScSZ Electrolyte: Low-Temperature Co-Sintering and High Performance
by
Shang Peng, Zhao Liu, Pairuzha Xiaokaiti, Tiancheng Fang, Jiwei Wang, Guoqing Guan and Abuliti Abudula
ChemEngineering 2025, 9(4), 66; https://doi.org/10.3390/chemengineering9040066 - 24 Jun 2025
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In this study, a novel anode-supported solid oxide fuel cell (SOFC) comprising a Bi2O3-doped NiO-ScSZ anode and an ScSZ electrolyte was successfully fabricated via a low-temperature co-sintering process at 1300 °C. The incorporation of 3 wt% Bi2O
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In this study, a novel anode-supported solid oxide fuel cell (SOFC) comprising a Bi2O3-doped NiO-ScSZ anode and an ScSZ electrolyte was successfully fabricated via a low-temperature co-sintering process at 1300 °C. The incorporation of 3 wt% Bi2O3 effectively promoted the sintering of both the anode support and electrolyte layer, resulting in a dense, gas-tight electrolyte and a mechanically robust porous anode support. X-ray diffraction (XRD) and scanning electron microscopy (SEM) analyses confirmed the formation of phase-pure, highly crystalline ScSZ with an optimized microstructure. Electrochemical performance measurements demonstrated that the fabricated cells achieved excellent power density, reaching a peak value of 0.861 W cm−2 at 800 °C under humidified hydrogen fuel conditions. The cells maintained stable performance under dry methane operation, with a maximum power density of 0.624 W cm−2 at 800 °C, indicating resistance to carbon deposition. Gas chromatographic analyses further revealed that the Bi2O3-doped NiO-ScSZ anode facilitated earlier and more stable electrochemical oxidation of methane-derived species compared with the conventional NiO-YSZ system, even under conditions of an elevated methane partial pressure. These findings demonstrate that Bi2O3 co-doping, combined with low-temperature co-sintering, provides an effective approach for fabricating high-performance intermediate-temperature SOFCs with enhanced structural integrity and electrochemical stability. The developed methodology presents a promising pathway toward achieving cost-effective and durable SOFC technologies.
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Open AccessArticle
Characterization of HFE 7500 Refrigerant Suspensions Containing Oxide and Nitride Nanoparticles: Thermal, Rheological, and Electrokinetic Insights
by
Serdar Ozturk and Keagan Schmidt
ChemEngineering 2025, 9(4), 65; https://doi.org/10.3390/chemengineering9040065 - 24 Jun 2025
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Nanofluids—engineered suspensions of nanometer-sized particles—have attracted significant attention due to their reportedly enhanced thermal properties, making them promising candidates for advanced heat transfer applications. However, despite extensive studies, uncertainties remain regarding the magnitude and origin of these effects, limiting their practical implementation. To
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Nanofluids—engineered suspensions of nanometer-sized particles—have attracted significant attention due to their reportedly enhanced thermal properties, making them promising candidates for advanced heat transfer applications. However, despite extensive studies, uncertainties remain regarding the magnitude and origin of these effects, limiting their practical implementation. To address this, we present a comprehensive study on nanofluid formulations based on the commercial refrigerant HFE-7500, incorporating surfactant-stabilized dispersions of several metal oxide and nitride nanoparticles. We measured key physicochemical properties, including zeta potential, particle size, viscosity, and thermal conductivity. Our results show that while the nanofluids exhibited high stability, their particle sizes in suspension were significantly larger than the primary nanoparticle sizes measured by TEM. Notably, alumina-based suspensions demonstrated the greatest enhancement, exhibiting approximately 10–15% increases in thermal conductivity as a function of volume percentage. These surpassed the 5–10% improvements observed with other metal oxides, an effect that may be linked to their comparatively larger particle sizes. However, the observed enhancements were lower than some previously reported values that claimed anomalously high thermal conductivity increases. Furthermore, steady shear viscosity increased with particle concentration, showing enhancements of 10–20%, which suggests a potential trade-off for practical implementation. Our findings refine the understanding of nanofluid behavior in refrigerants and establish a foundation for optimizing their performance in thermal management applications. However, viscosity increases must be carefully considered when designing next-generation nanofluids for real-world use.
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Open AccessArticle
Kinetic and Thermodynamic Study of Cationic Dye Removal Using Activated Biochar Synthesized from Prosopis juliflora Waste
by
Andrés Abuabara, Carlos Diaz-Uribe, William Vallejo, Freider Duran and Edgar Mosquera-Vargas
ChemEngineering 2025, 9(3), 64; https://doi.org/10.3390/chemengineering9030064 - 19 Jun 2025
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In this study, we synthesized an activated biochar using Prosopis juliflora waste as a carbon source. Citric acid (CA) was used as the chemical agent for biochar activation. The removal of methylene blue (MB) using the fabricated biochar was investigated. A response surface
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In this study, we synthesized an activated biochar using Prosopis juliflora waste as a carbon source. Citric acid (CA) was used as the chemical agent for biochar activation. The removal of methylene blue (MB) using the fabricated biochar was investigated. A response surface methodology (RSM) experimental design was employed to evaluate the effects of synthesis parameters, including the temperature and the CA/biochar mass ratio, on the biochar’s MB removal efficiency. The impact of adsorption parameters, such as the biochar dosage, pH, MB concentration, and ionic strength, was also examined. Kinetic and isothermal adsorption studies were conducted to assess the efficacy of the activated biochar. The kinetic study revealed a maximum adsorption capacity (qe) of 37.6 mg/g and a rate constant of 0.0022 g mg−1 min−1, with the pseudo-second-order model providing the best fit. The isotherm study indicated that the Freundlich model best described the data, with KF = 37.8 mg/g and 1/nf = 0.498. Thermodynamic analysis showed that the MB adsorption onto the biochar was spontaneous (ΔG = −9.14 kJ/mol), endothermic (ΔH = 17.87 kJ/mol), and driven by an entropy increase (ΔS = 89.20 J/mol·K).
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Open AccessTechnical Note
Growth of a Single Bubble Due to Super-Saturation: Comparison of Correlation-Based Modelling with CFD Simulation
by
Johannes Manthey, Wei Ding, Hossein Mehdipour, Montadhar Guesmi, Simon Unz, Uwe Hampel and Michael Beckmann
ChemEngineering 2025, 9(3), 63; https://doi.org/10.3390/chemengineering9030063 - 17 Jun 2025
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This paper investigates and assesses the potential applicability of global mass transfer coefficients derived from large-scale experiments to the bubble growth of a single bubble in a super-saturated flow . Therefore, it presents, for a specific flow velocity
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This paper investigates and assesses the potential applicability of global mass transfer coefficients derived from large-scale experiments to the bubble growth of a single bubble in a super-saturated flow . Therefore, it presents, for a specific flow velocity , a comparison between correlation-based modelling and 3D Large Eddy Simulation–Volume of Fluid (LES-VOF) Computational Fluid Dynamics (CFD) simulations (minimum cell size of 10 µm, Δt = 10 µs). After the verification of the CFD with pool nucleation bubbles, two cases are regarded: (1) the bubble flowing in the bulk and (2) a bubble on a wall with a crossflow. The correlation-based modelling results in a nearly linear relationship between bubble radius and time; meanwhile, theoretically, the self-similarity rule offers . The Avdeev correlation gives the best agreement with the CFD simulation for a bubble in the flow bulk (case 1), while the laminar approach for calculation of the exposure time of the penetration theory shows good agreement with the CFD simulation for the bubble growth at the wall (case 2). This preliminary study provides the first quantitative validation of global mass transfer coefficient correlations at the single-bubble scale, suggesting that computationally intensive CFD simulations may be omitted for rapid estimations. Future work will extend the analysis to a wider range of flow velocities and bubble diameters to further validate these findings.
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Open AccessArticle
Mechanisms and Optimization of Foam Flooding in Heterogeneous Thick Oil Reservoirs: Insights from Large-Scale 2D Sandpack Experiments
by
Qingchun Meng, Hongmei Wang, Weiyou Yao, Yuyang Han, Xianqiu Chao, Tairan Liang, Yongxian Fang, Wenzhao Sun and Huabin Li
ChemEngineering 2025, 9(3), 62; https://doi.org/10.3390/chemengineering9030062 - 4 Jun 2025
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To address the challenges of low displacement efficiency and gas channeling in the Lukqin thick oil reservoir, characterized by high viscosity (286 mPa·s) and strong heterogeneity (permeability contrast 5–10), this study systematically investigated water flooding and foam flooding mechanisms using a large-scale 2D
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To address the challenges of low displacement efficiency and gas channeling in the Lukqin thick oil reservoir, characterized by high viscosity (286 mPa·s) and strong heterogeneity (permeability contrast 5–10), this study systematically investigated water flooding and foam flooding mechanisms using a large-scale 2D sandpack model (5 m × 1 m × 0.04 m). Experimental results indicate that water flooding achieves only 30% oil recovery due to a mobility ratio imbalance (M = 128) and preferential channeling. In contrast, foam flooding enhances recovery by 15–20% (final recovery: 45%) through synergistic mechanisms of dynamic high-permeability channel plugging and mobility ratio optimization. By innovatively integrating electrical resistivity tomography with HSV color mapping, this work achieves the first visualization of foam migration pathways in meter-scale heterogeneous reservoirs at a spatial resolution of ≤0.5 cm, reducing monitoring costs by approximately 30% compared to conventional CT techniques. Key controlling factors for gas channeling (injection rate, foam quality, permeability contrast) are identified, and a nonlinear predictive model for plugging strength ((S = 0.70C0.6 kr−0.28) (R2 = 0.91)) is established. A composite optimization strategy—combining high-concentration slugs (0.7% AOS), salt-resistant polymer-enhanced foaming, and multi-round profile control—achieves a 67% reduction in gas channeling. This study elucidates the dynamic plugging mechanisms of foam flooding in heterogeneous thick oil reservoirs through large-scale physical simulations and data fusion, offering direct technical guidance for optimizing foam flooding operations in the Lukqin Oilfield and analogous reservoirs.
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Open AccessArticle
Optimizing Biomethane Production from Industrial Pig Slurry and Wine Vinasse: A Mathematical Approach
by
Belén Cañadas, Juana Fernández-Rodríguez, Rosario Solera and Montserrat Pérez
ChemEngineering 2025, 9(3), 61; https://doi.org/10.3390/chemengineering9030061 - 3 Jun 2025
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Pig slurry (PS) and wine vinasse (WV) pose environmental risks if not properly managed. Their composition makes them suitable for anaerobic co-digestion (AcoD), enhancing biomethane production and improving organic matter degradation efficiency. This research applies an innovative Design of Experiments (DoE) approach—specifically the
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Pig slurry (PS) and wine vinasse (WV) pose environmental risks if not properly managed. Their composition makes them suitable for anaerobic co-digestion (AcoD), enhancing biomethane production and improving organic matter degradation efficiency. This research applies an innovative Design of Experiments (DoE) approach—specifically the Box–Behnken design (BBD)—to systematically optimize the AcoD process, surpassing traditional single-factor methods by efficiently evaluating the interactions. Variables such as temperature (35 °C, 52.5 °C, 70 °C), substrate ratio (25PS:75WV, 50PS:50WV, 75PS:25WV) and pH (7, 7.5, 8) were tested using a Box–Behnken design which studied the correlations between the experimental data and the model. In fact, the results showed that temperature, ratio, and their interaction significantly influenced biomethane production, being the pH the factor with the least influence on the response. Optimal conditions—pH of 8, temperature of 35 °C and a 50:50 substrate ratio—achieved a biomethane yield of 487.94 CH4/gVS (Volatile Solids). These results demonstrate the effectiveness of the DoE methodology in maximizing biomethane production and represent a significant advancement in valorizing wastes from pig farms and wineries, promoting a circular and sustainable economy.
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Open AccessArticle
The Re-Modeling of a Polymeric Drug Delivery System Using Smart Response Surface Designs: A Sustainable Approach for the Consumption of Fewer Resources
by
Magdy M. Aly, Shaimaa S. Ibrahim and Rania M. Hathout
ChemEngineering 2025, 9(3), 60; https://doi.org/10.3390/chemengineering9030060 - 1 Jun 2025
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Introduction: The use of response surface designs for drug formulation is highly warranted nowadays. Such smart designs reduce the number of required experiments compared to full-factorial designs, while providing highly accurate and reliable results. Aim: This study compares the effectiveness of
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Introduction: The use of response surface designs for drug formulation is highly warranted nowadays. Such smart designs reduce the number of required experiments compared to full-factorial designs, while providing highly accurate and reliable results. Aim: This study compares the effectiveness of two of the most commonly used response surface designs—Central Composite Design (CCD) and D-optimal Design (DOD)—in modeling a polymer-based drug delivery system. The performance of the two designs was further evaluated under a challenging scenario where a central point was deliberately converted into an outlier. Methods: Both methods were assessed using ANOVA, R-squared values, and adequate precision, and were assessed through an experimental validation point. Results: Both models demonstrated statistical significance (p-value < 0.05), confirming their ability to describe the relationships between formulation variables and critical quality attributes (CQAs). CCD achieved higher R-squared and predicted R-squared values compared to DOD (0.9977 and 0.9846 vs. 0.8792 and 0.7858, respectively), rendering it as the superior approach in terms of modeling complex variables’ interactions. However, DOD proved to be more predictive as it scored a lower percentage relative error. Conclusion: The demonstrated resilience of both models, despite the introduction of an outlier, further validates their utility in real-world applications, instead of the exhaustive full-factorial design.
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Open AccessArticle
Solving a Challenge in the Tequila Industry: A New Continuous Rectification Process for Reducing Higher Alcohols and Obtaining Products Within the Official Tequila Standard
by
Héctor Flores-Martínez, Isaac Guadalupe Tejeda-Arandas, Mirna Estarrón-Espinosa and José Daniel Padilla-de la Rosa
ChemEngineering 2025, 9(3), 59; https://doi.org/10.3390/chemengineering9030059 - 1 Jun 2025
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This work is the first to study the effect of residence time on the volatile composition of distilled fractions of ordinario using a horizontal continuous distiller of our own manufacture. The ordinario used in this research had a high amount of higher alcohols,
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This work is the first to study the effect of residence time on the volatile composition of distilled fractions of ordinario using a horizontal continuous distiller of our own manufacture. The ordinario used in this research had a high amount of higher alcohols, so its adequate distillation is complicated. The fractions rectified by continuous distillation were compared with those obtained by batch distillation. Five distilled fractions were collected, and their combined volume was subjected to gas chromatography (GC) analysis to determine the principal volatile compounds (furfural, aldehyde, higher alcohols, methanol, and ester contents). A variance analysis of each group of volatile compounds was conducted to evaluate the effect of residence time (2 and 4 h) in continuous distillation compared to batch distillation (4 h). Continuous rectification allowed for obtaining a distillate within the permissible limits specified by the Official Mexican Standard (NOM-006-SCFI-2012). For the continuous 2 h, continuous 4 h, and batch 4 h processes, the higher alcohols, esters, and aldehydes showed a decreasing pattern, while methanol and furfural showed an increasing pattern in relation to the fraction number. An analysis of variance showed no statistically significant differences in terms of the regulated volatile composition (higher alcohols, esters, methanol, and furfural) according to process type (continuous 2 h, continuous 4 h, and batch 4 h), except for aldehydes, which presented differences. This new continuous rectification process increases productivity while reducing the processing time by 50%, keeping the composition and volume of the heart fraction.
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Graphical abstract
Open AccessSystematic Review
Valorization of Lignocellulosic Biomass to Biofuel: A Systematic Review
by
Mbuyu Germain Ntunka, Siphesihle Mangena Khumalo, Thobeka Pearl Makhathini, Sphesihle Mtsweni, Marc Mulamba Tshibangu and Joseph Kapuku Bwapwa
ChemEngineering 2025, 9(3), 58; https://doi.org/10.3390/chemengineering9030058 - 29 May 2025
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Lignocellulosic biomass, derived from plant materials, represents a renewable alternative to fossil fuels and plays a crucial role in advancing environmental sustainability. This systematic review investigates recent developments in the conversion of lignocellulosic biomass into biofuels, with a focus on pre-treatment technologies that
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Lignocellulosic biomass, derived from plant materials, represents a renewable alternative to fossil fuels and plays a crucial role in advancing environmental sustainability. This systematic review investigates recent developments in the conversion of lignocellulosic biomass into biofuels, with a focus on pre-treatment technologies that enhance enzymatic hydrolysis, a critical step in efficient biofuel production. This review addresses two primary questions: (1) What are the most effective pre-treatment methods for enhancing enzymatic hydrolysis in lignocellulosic biomass conversion? (2) How do these pre-treatment methods compare in terms of efficiency, environmental impact, and economic feasibility? Consequently, studies were selected based on inclusion criteria that focus on research investigating these pre-treatment methods and their comparative performance. A structured search of original studies was applied across databases such as Crossref, Google Scholar, Scopus, PubMed, and Semantic Scholar, resulting in the inclusion of 17 peer-reviewed articles published between 2019 and 2024. The findings highlight effective pre-treatment methods that significantly improve enzymatic accessibility and bioethanol yields. However, ongoing challenges such as feedstock variability, process efficiency, and cost-effectiveness remain. These results highlight the need for further research and development to optimize conversion technologies and identify new areas for exploration.
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Open AccessArticle
Effect of Rotation Speed and Powder Bed Volume on Powder Flowability Measured by a Powder Rheometer: Evaluation of the Humidity Effect on Lactose Powder Flowability
by
Takamasa Mori, Kanaho Sakurada and Kenta Kitamura
ChemEngineering 2025, 9(3), 57; https://doi.org/10.3390/chemengineering9030057 - 29 May 2025
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Relative humidity during storage is known to affect powder flowability, although its effect on powder flowability remains unclear. Various techniques have been used to evaluate powder flowability, including measurement of the rotational torque of the powder bed, which is a novel method. However,
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Relative humidity during storage is known to affect powder flowability, although its effect on powder flowability remains unclear. Various techniques have been used to evaluate powder flowability, including measurement of the rotational torque of the powder bed, which is a novel method. However, studies investigating the effect of relative humidity on powder flowability using rotational torque measurements are limited. Therefore, this study aimed to examine the influence of relative humidity during storage on the flowability of lactose powder through rotational torque measurement of the powder bed using an Anton Paar powder rheometer. Rotation speed had a minimal effect, except when the powder was stored at a high relative humidity of 99%. The effect of relative humidity was more pronounced at a smaller powder volume (30 mL) than that at the other volumes tested. Of the techniques employed, including the angle of repose and bulk density measurements, the rotational torque measurement of the powder rheometer exhibited the highest sensitivity to variations in relative humidity. It was also found that the measured rotation torque hardly changed when the rotation speed was below a critical value, indicating that the optimal rotation speed exists to measure the representative rotation torque of each powder.
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Open AccessReview
Liposome-Based Drug Delivery Systems: From Laboratory Research to Industrial Production—Instruments and Challenges
by
Suman Basak and Tushar Kanti Das
ChemEngineering 2025, 9(3), 56; https://doi.org/10.3390/chemengineering9030056 - 27 May 2025
Abstract
Liposome-based drug delivery systems have revolutionized modern pharmaceutics, offering unparalleled versatility and precision in therapeutic delivery. These lipid vesicles, capable of encapsulating hydrophilic, hydrophobic, and amphiphilic drugs, have demonstrated significant potential in addressing pharmacokinetic challenges such as poor solubility, systemic toxicity, and rapid
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Liposome-based drug delivery systems have revolutionized modern pharmaceutics, offering unparalleled versatility and precision in therapeutic delivery. These lipid vesicles, capable of encapsulating hydrophilic, hydrophobic, and amphiphilic drugs, have demonstrated significant potential in addressing pharmacokinetic challenges such as poor solubility, systemic toxicity, and rapid clearance. This review provides a comprehensive exploration of the evolution of liposomes from laboratory models to clinically approved therapeutics, highlighting their structural adaptability, functional tunability, and transformative impact on modern medicine. We discuss pivotal laboratory-scale preparation techniques, including thin-film hydration, ethanol injection, and reverse-phase evaporation, along with their inherent advantages and limitations. The challenges of transitioning to industrial-scale production are examined, with emphasis on achieving batch-to-batch consistency, scalability, regulatory compliance, and cost-effectiveness. Innovative strategies, such as the incorporation of microfluidic systems and advanced process optimization, are explored to address these hurdles. The clinical success of Food and Drug Administration (FDA)-approved liposomal formulations such as Doxil® and AmBisome® underscores their efficacy in treating conditions ranging from cancer to fungal infections. Furthermore, this review delves into emerging trends, including stimuli-responsive and hybrid liposomes, as well as their integration with nanotechnology for enhanced therapeutic precision. As liposomes continue to expand their role in gene therapy, theranostics, and personalized medicine, this review highlights their potential to redefine pharmaceutical applications. Despite existing challenges, ongoing advancements in formulation techniques and scalability underscore the bright future of liposome-based therapeutics in addressing unmet medical needs.
Full article
(This article belongs to the Special Issue New Trends in (Bio)chemical Engineering: Biobased Pharmaceutical Processes)
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Open AccessArticle
Electrification of Compressor in Steam Cracker Plant: A Path to Reduced Emissions and Optimized Energy Integration
by
Joana Cordeiro Torcato, Rodrigo Silva and Mário Eusébio
ChemEngineering 2025, 9(3), 55; https://doi.org/10.3390/chemengineering9030055 - 27 May 2025
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Electrification is a highly effective decarbonization and environmental incentive strategy for the chemical industry. Nevertheless, it may lead to downstream challenges in the process. This study analyzes the consequences of electrifying compressors within the steam cracker (SC) condensate system, focusing on the reduction
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Electrification is a highly effective decarbonization and environmental incentive strategy for the chemical industry. Nevertheless, it may lead to downstream challenges in the process. This study analyzes the consequences of electrifying compressors within the steam cracker (SC) condensate system, focusing on the reduction in greenhouse gas (GHG) emissions and energy consumption without compromising the process’s energy efficiency. The aim is to study the impact that the reduction in steam expanded by turbines has on boiler feedwater (BFW) temperature and, subsequently, the behavior it triggers in fuel gas (FG) consumption and carbon dioxide (CO2) emissions in furnaces. It was concluded that condensate imports from the Energies and Utilities Plant (E&U) would increase by a factor of four, with approximately 60% of the imported condensate being cold condensate. The study revealed a mitigation of CO2 emissions, resulting in a 1.3% reduction and a reduction in FG consumption of 1.8% preventing an increase in site energy consumption by 795.4 kW in furnaces. Condenser optimization reduces CO2 emissions by 60%. Energy integration with quench water resulted in heat saving of 1824 kW in hot utility consumption and generating annual savings of EUR 2.3 M. The global carbon dioxide balance can achieve up to a 25% reduction.
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Open AccessArticle
From Conjugation to Detection: Development of Lateral Flow Assay for Zearalenone
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Vinayak Sharma, Bilal Javed, Hugh J. Byrne and Furong Tian
ChemEngineering 2025, 9(3), 54; https://doi.org/10.3390/chemengineering9030054 - 26 May 2025
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The development of rapid, sensitive and cost-effective lateral flow assays is crucial for the detection of mycotoxins, ideally at the point-of-care level. This study presents the design and optimization of a competitive lateral flow assay based on gold nanoparticles (AuNPs) for the detection
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The development of rapid, sensitive and cost-effective lateral flow assays is crucial for the detection of mycotoxins, ideally at the point-of-care level. This study presents the design and optimization of a competitive lateral flow assay based on gold nanoparticles (AuNPs) for the detection of zearalenone in food samples. Beginning with the synthesis and functionalization of gold nanoparticles, it proceeds to compare the immobilization of antibodies using chemical conjugation and physical adsorption binding strategies, upon optimizing parameters including the pH, antibody concentration and blocking conditions to enhance the stability of the prepared bioconjugates. The bioconjugates are characterized using UV–visible absorption spectroscopy and dynamic light scattering to monitor changes in the spectra and hydrodynamic size of AuNPs upon the addition of antibodies. The assessment of these bioconjugates is based on their ability to bind and manifest a color, developed due to nanoparticle binding with the test zone on the strip with the toxin–protein conjugate. The lateral flow immunochromatographic assay (LFIA) strips are then prepared by dispensing a control line (IgG) and test line (toxin–protein conjugate) on a nitrocellulose membrane using a lateral flow strip dispenser. The sensitivity of the LFIA strips is evaluated after standardizing the conditions by varying the concentration of zearalenone in the spiked samples and optimizing the running buffer solution. The limit of detection and limit of quantification under optimized conditions are determined to be 0.7 ng/mL and 2.37 ng for zearalenone-spiked samples. Furthermore, the mean pixel intensity and RGB values are plotted against the concentration of zearalenone, which can be used in a colorimetric smartphone-based application for the quantification of the amount of mycotoxin in the sample.
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Open AccessArticle
An Upgraded FOS/TAC Titration Model Integrating Phosphate Effects for Accurate Assessments of Volatile Fatty Acids and Alkalinity in Anaerobic Media
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Xiaojun Liu, André Pauss, Laura André and Thierry Ribeiro
ChemEngineering 2025, 9(3), 53; https://doi.org/10.3390/chemengineering9030053 - 22 May 2025
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The accurate determination of volatile fatty acids (VFAs) and total alkalinity (TAC, mostly carried by bicarbonate ions) is critical for operating anaerobic digesters. The FOS/TAC titration method developed by Nordmann is widely used due to its simplicity and affordability. This method has known
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The accurate determination of volatile fatty acids (VFAs) and total alkalinity (TAC, mostly carried by bicarbonate ions) is critical for operating anaerobic digesters. The FOS/TAC titration method developed by Nordmann is widely used due to its simplicity and affordability. This method has known limitations in dosing VFAs and TAC, since the presence of one interferes with the determination of the other, especially at higher VFA or bicarbonate concentrations. This study builds upon our prior research in 2021 by integrating the influence of phosphate (H2PO4−/HPO42−) into numerical models correcting FOS/TAC titration results. A Scilab-based program was used to assess the impact of phosphate on titration results, revealing significant biases at lower concentrations. A revised multivariate regression formula was developed, incorporating phosphate effects, and demonstrating superior accuracy. The mean absolute percentage errors (MAPE) for TAC and VFA estimation were reduced to less than 0.3%. The model maintains compatibility with standard Nordmann’s titration protocols and equipment while significantly improving reliability. These findings highlight the necessity of considering phosphate interference in FOS/TAC titration, particularly in AD systems with variable buffering conditions. The proposed correction model enhances process monitoring and control, providing a more robust tool for both research and industrial practice in anaerobic digestion.
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Open AccessArticle
Robust Enhanced Auto-Tuning of PID Controllers for Optimal Quality Control of Cement Raw Mix via Neural Networks
by
Dimitris Tsamatsoulis
ChemEngineering 2025, 9(3), 52; https://doi.org/10.3390/chemengineering9030052 - 20 May 2025
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Ensuring efficient long-term quality control of the raw mix remains a priority for the cement industry, supporting initiatives to lower the CO2 footprint by incorporating significant amounts of alternative fuels and raw materials in clinker production. This study presents an effective method
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Ensuring efficient long-term quality control of the raw mix remains a priority for the cement industry, supporting initiatives to lower the CO2 footprint by incorporating significant amounts of alternative fuels and raw materials in clinker production. This study presents an effective method for creating a robust auto-tuner for proportional–integral–differential (PID) controller control of the lime saturation factor (LSF) of the raw mix using artificial neural networks (ANNs). This auto-tuner, combined with a previously studied robust PID controller, forms an integrated system that adapts to process changes and maintains low long-term variance in LSF. The ANN links each of the three PID gains to the process dynamic parameters, with the three ANNs also interconnected. We employed the Levenberg–Marquardt method to optimize the ANNs’ synaptic weights and applied the weight decay method to prevent overfitting. The industrial implementation of our control system, using the auto-tuner for 16,800 h of raw mill operation, shows an average LSF standard deviation of 2.5, with fewer than 10% of the datasets exceeding a standard deviation of 3.5. Considering that the measurement reproducibility is 1.44 and assuming a low mixing ratio of the raw meal in the silo equal to 2, the LSF standard deviation in the kiln feed approaches the analysis reproducibility, indicating that disturbances in the raw meal largely diminish in the kiln feed. In conclusion, integrating traditional, well-established tools like PID controllers with newer advanced techniques, such as ANNs, can yield innovative solutions.
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Open AccessArticle
Waste-to-Energy Potential of Petroleum Refinery Sludge, Statistical Optimization, Machine Learning, and Life Cycle Costs Models
by
Seyyed Roohollah Masoomi, Mohammad Gheibi, Reza Moezzi, Kourosh Behzadian, Atiyeh Ardakanian, Farzad Piadeh and Andres Annuk
ChemEngineering 2025, 9(3), 51; https://doi.org/10.3390/chemengineering9030051 - 16 May 2025
Abstract
Sludge management in petroleum refineries is a costly and complex challenge, posing environmental risks and health hazards for humans. This study explores sludge incineration as a viable energy recovery method, using a case study from an Iranian refinery. Analysis of 15 sludge samples
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Sludge management in petroleum refineries is a costly and complex challenge, posing environmental risks and health hazards for humans. This study explores sludge incineration as a viable energy recovery method, using a case study from an Iranian refinery. Analysis of 15 sludge samples via bomb calorimetry revealed an average heat value of 3100 kcal/kg, which declines with increased moisture content, while higher chemical oxygen demand (COD) enhances energy yield. Over five years, 4000 tonnes of accumulated sludge presented an energy potential of 12,400 Gcal. Statistical modeling, including polynomial regression and response surface methodology (RSM), mapped sludge storage profiles and predicted calorific values based on COD and moisture variations. The results indicate anaerobic digestion at greater depths reduces organic matter, lowering energy potential. Differential scanning calorimetry (DSC) analysis confirmed key thermal transitions, supporting sludge incineration as an effective waste-to-energy strategy. Implementing this approach within a circular economy framework can optimize refinery waste management while reducing pollution, though proper combustion byproduct control is essential for sustainability and regulatory compliance.
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(This article belongs to the Special Issue Innovative Approaches for the Environmental Chemical Engineering)
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Open AccessArticle
Decoloration of Waste Cooking Oil by Maghnia Algerian Clays via Ion Exchange and Surface Adsorption
by
Abdelhak Serouri, Zoubida Taleb, Alberto Mannu, Chahineze Nawel Kedir, Cherifa Hakima Memou, Sebastiano Garroni, Andrea Mele, Oussama Zinai and Safia Taleb
ChemEngineering 2025, 9(3), 50; https://doi.org/10.3390/chemengineering9030050 - 16 May 2025
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The purification of waste cooking oils (WCOs) through clay-based adsorption is an established recycling method, yet the relationship between clay composition and adsorption efficiency remains an area of active research. The aim of the present research work was to assess the performance of
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The purification of waste cooking oils (WCOs) through clay-based adsorption is an established recycling method, yet the relationship between clay composition and adsorption efficiency remains an area of active research. The aim of the present research work was to assess the performance of Maghnia bentonite in WCO decoloration and to gain information about the specific refining process. Thus, natural bentonite from the Maghnia region (Algeria) was investigated as an adsorbent for WCO refining for biolubricant production. The adsorption efficiency was evaluated under different conditions, achieving up to 70% decolorization at 10 wt% clay after 4 h of treatment. Structural characterization of the bentonite before and after adsorption was conducted using FT-IR spectroscopy, powder X-ray diffraction (XRD), and X-ray fluorescence (XRF) to assess compositional and morphological changes. FT-IR analysis confirmed the adsorption of organic compounds, XRD indicated minor alterations in interlayer spacing, and XRF revealed ion exchange mechanisms, including a reduction in sodium and magnesium and an increase in calcium and potassium. Adsorption kinetics followed a pseudo-second-order model, with desorption effects observed at prolonged contact times. The pHPZC of 8.3 suggested that bentonite adsorption efficiency is enhanced under acidic conditions. The high decoloration capacity of Maghnia bentonite, combined with the availability and the low cost of the material, suggests a possible industrial application of this material for WCO refinement, especially in lubricant production.
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