Regulation of Lipid Metabolism in Health and Disease

Dear Colleagues,

Lipids are essential for whole body function as they provide energy, contribute to cellular structure, and regulate essential metabolic pathways and physiological processes by acting as powerful signals for intracellular and inter-organ communication. Lipids become available to the body through ingestion in the diet or de novo synthesis within the cells. The regulation of lipid metabolism involves multiple intricate pathways, which are strictly regulated in healthy individuals.

In biological tissues, lipids are in a dynamic state of continuous synthesis and break down. Lipid metabolism includes the intestinal absorption of dietary lipids, lipid transport and storage, breakdown of complex lipids by catabolic pathways, and the synthesis of fatty acids and other sophisticated lipid molecules, such as phospholipids, ceramides, prostaglandins, and steroid hormones. Evolving research has identified key enzymes and subtypes of lipids involved in the regulation of these processes. For example, fatty acids have the potential to modulate lipid storage and breakdown by controlling the expression of various genes involved in these metabolic pathways.

Accumulating evidence demonstrates that lipid metabolism is dysregulated in a variety of human pathologies and clinical conditions, including obesity, diabetes, fatty liver, atherosclerosis, cancer, and neurodegenerative disease. Therefore, there is an urgent need to advance the investigation of all aspects of lipid metabolism in these pathologies in order to develop novel and more efficient therapies. This Special Issue of Cells, entitled “Regulation of Lipid Metabolism in Health and Disease”, aims to present a collection of articles related to all aspects of lipid metabolism in health and disease, including, but not limited to, obesity, diabetes, cancer, and neurodegenerative disease. Manuscripts dealing with other relevant issues will also be considered. Both original research (preclinical and clinical) and review articles are welcome.

Prof. Dr. Dolores Serra
Dr. Paula Mera Nanin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• lipid metabolism
• obesity
• diabetes
• cancer
• cardiovascular disease
• neurodegenerative disease