Role of p53 in Cell Death and Cancers
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 4646
Special Issue Editors
Interests: tumor suppressor; cancer stem cells; signaling pathway; target therapy
Interests: cancer; cell cycle; cellular senescence; endoplasmic reticulum stress; molecular target drugs; p53; transcriptional regulation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Since the tumor suppressor gene p53 was discovered about 40 years ago, research is still ongoing by many cancer researchers in the world. p53 is one of the most famous tumor suppressors and the most frequently inactivated in a variety of hunman cancers. Through its transcriptional activity, p53 is involved in various stress responses and phentotypes, such as DNA damage response, cell death, and cellular senescence. In addition, recent studies have revealed p53 functions in energy metabolism, antioxidant function, and intracellular metabolic reprogramming. These physiological functions can be demonstrated by the diversity of functions of a huge number of p53 target genes. Furthermore, the new functions of p53 have been elucidated by integrating transcriptome analysis with the latest genome analysis technologies, such as next-generation sequencing and metabolomics analysis. Thus, it is still necessary to elucidate the physiological function of p53, which continues to expand. Here, we welcome papers describing original research and review articles to understand the role of p53 function in cell fate decisions and various diseases, including cancer.
Prof. Kiyotsugu Yoshida
Prof. Hidetoshi Hayashi
Guest Editors
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Keywords
- angiogenesis
- apoptosis
- autophagy
- cancer
- cell cycle
- cell death
- cellular stress
- DNA damage
- DNA repair
- drug sensitivity
- genome stability
- metabolism
- molecular target drugs
- p53
- senescence
- stemness
