Oxidative Stress and Cell Dysfunction
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 888
Special Issue Editor
Special Issue Information
Dear Colleagues,
Oxidative stress occurs as a result of an imbalance between the formation and neutralization of free radicals—specifically, reactive oxygen (ROS). Endogenous ROS produced in mitochondria, peroxisomes, the endoplasmic reticulum, phagocytes and cell membranes are a product of normal cellular metabolism. Cells in a multicellular organism have differentiated to fulfill organotypic and specialized functions and evolved to manage oxidative stress in an optimal way. However, exogenous factors, including environmental pollution, heavy metals, radiation and unfavorable life-styles (smoking, drugs, malnutrition) continuously challenge the oxidative-stress/redox balance and hemostasis.
Excessive ROS cause damage to macromolecules such as proteins, lipids and DNA, affecting longevity and perpetuating chronic inflammation and (multi)cellular dysfunction, with heterogenous (patho)physiologic outcomes including atherosclerosis, autoimmune and metabolic disorders and cancer. Although these pathologies are ascribed to oxidative stress, the autocrine and paracrine molecular feedback mechanisms engaged in different cell types and organs are less well understood.
The goal of this Special Issue is to decipher the impact of oxidative stress at multiple levels, i.e., at the organelle level, single-cell and cell-type-specific level, at the level of “monocultures” and “mixed-cultures”, autocrine and paracrine (i.e., vesicles) dissemination of oxidative stress and finally in the context of organs and hemostasis. Original research and review articles are welcome.
Potential topics include, but are not limited to, the following:
- Sources of oxidative stress at the organelle level;
- Cell-type-specific oxidative stress management (endothelial, epithelial, neuronal, etc.);
- Metabolite, protein, lipid, carbohydrate, and nucleic acid markers of oxidative stress;
- Autocrine and paracrine (short and long (vesicles) distance) oxidative stress management.
Dr. Ulrike Resch
Guest Editor
Manuscript Submission Information
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Keywords
- oxidative stress
- organelles
- cellular stress
- stress management
- cell structures
- cell dysfunction
- stress diseases
- free radicals
- inflammation
- reactive oxygen
- ROS
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