Interplay between ncRNAs and Cellular Communication in Metabolism and Metabolic Disease

Dear Colleagues,

Cardiology aims at understanding the circulatory dynamics via the elucidation of the mechanisms underlying the means of mutual communication by wide variety of cells building the cardiovascular system, orchestrating coherent responses to external stimuli. The cardiovascular system is closely related with metabolic disorders, and the elucidation of the biological basis of this association allows us to better understand the mechanisms underlying the disruption of circulatory homeostasis and to develop novel approaches to the prevention of the development of cardiovascular diseases (CVD).

This Special Issue of Cells is dedicated to the link between CVD and metabolic disorder from the point of view of epigenetic mechanisms. Obesity is a world-wide epidemic and intimately associated with the development of metabolic disorders and type 2 diabetes, leading to the development of CVD. Despite extensive efforts, the prevalence of obesity and metabolic disorders has strikingly increased; therefore, novel therapeutic approaches are currently needed in terms of the prevention of CVD.

Great technological progress has also brought new possibilities in the field of cardiology. Not only have genome-wide association studies (GWAS) and other high throughput approaches become available but new levels of gene expression regulation, such as epigenetics or microRNAs, are being explored in molecular and biological studies focusing on the cardiovascular system. Animal models used in preclinical studies have become more advanced and, combined with modern biochemical and molecular approaches, have helped us to get closer to understanding the crosstalk between metabolic disease and CVD. However, we are still far from the main goal, i.e., a full understanding of metabolic disease-related CVD pathogenesis and efficient therapy.

We are strongly convinced that new studies elucidating the mechanisms of metabolic diseases and exploring novel therapeutic strategies are urgent. Therefore, we invite and encourage all authors who are in possession of interesting data to contribute to this Special Issue of Cells with an original research or review article. Let us make this Special Issue of Cells a breakthrough in the search for the molecular and cellular causes of metabolic diseases.

We are looking forward to your contributions to this Special Issue.

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• cardiovascular diseases
• metabolic disease
• atherosclerosis
• maternal nutrition
• fetal development
• psychosocial stress
• depression
• neutrophil
• monocyte
• macrophage
• trained immunity
• epigenetics