Hereditary Lysosomal Diseases: Molecular and Cellular Aspects
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Intracellular and Plasma Membranes".
Deadline for manuscript submissions: closed (10 May 2021) | Viewed by 215
Special Issue Editors
Interests: lysosomal disease; autophagy; lysosome; endosomal-lysosomal system; endo-lysosomal trafficking
Interests: neurodegenerative disease; lysosome; lysosomal disease; signaling pathways; membrane trafficking; disease genetics
Special Issue Information
Dear Colleagues,
We are pleased to announce a special issue of Cells, “Hereditary Lysosomal Diseases: Molecular and Cellular Aspects”, and invite you to contribute.
More than 50 lysosomal diseases are now recognized, and rapid advances in molecular diagnostics and therapeutic development are improving speed to diagnosis and treatment options. However, a thorough understanding of this complex organelle, its interactions within cell signalling and metabolism, its connections with other organelles, and how lysosomal disease gene mutations lead to cellular dysfunction and loss remains a major area of active research. Further advances are needed to establish the underlying mechanisms of diseases arising from this organelle in order to succeed in developing new targeted therapies. Progress in hereditary lysosomal diseases will undoubtedly also advance understanding of the role of the lysosome in more common disease, such as Parkinson’s disease and Alzheimer’s disease, and frontotemporal dementia, where overlapping disease risk genes have been demonstrated. This Special Issue of Cells aims to bring together recent discoveries in the molecular and cellular aspects of lysosomal and associated diseases, with an emphasis on hereditary lysosomal diseases, but also in disease areas where lysosomal dysfunction plays a role.
We invite you to submit your primary research reports and timely review articles for publication consideration and are looking forward to your contributions to this Special Issue. We encourage you to suggest topics for review articles within the remit of this Special Issue and to discuss these in advance with the Editors.
Dr. Susan L. Cotman
Dr. Sara Mole
Guest Editors
Manuscript Submission Information
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Keywords
- Lysosomal disease
- Autophagy
- Lysosome
- Endosomal-lysosomal system
- Endo-lysosomal trafficking
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