The Role of Cellular Organelles in Neurodevelopmental and Neurological Disorders
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: closed (1 December 2023) | Viewed by 306
Special Issue Editor
Interests: mitochondrial fragmentation; mitochondria-ER contacts; neurological disorders; RNA m6A modification; neuron-glia crosstalk
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The role of the cellular organelles in neurodevelopmental and neurological disorders has received increasing attention over the past few years. These disorders are common disabilities primarily associated with the functioning of the brain and likely result from a combination of genetic and environmental risk factors. Dysfunctions of the cellular organelles such as mitochondria, endoplasmic reticulum (ER), lysosomes, endosomes, Golgi apparatus, ribosomes, and autophagosome play important roles in multiple brain disorders. However, the way that these organelle dysfunctions contribute to disease progressions in different brain cell types remains to be elucidated. Additionally, crucial physiological functions of cells are regulated by complex organelle crosstalk including mitochondrial–ER contacts (MERCs), mitochondria–endolysosomal systems, autophagy–lysosomal pathways, and exosome–autophagy pathways, etc. It’s still largely unknown how the dysfunction of organelle crosstalk regulates the progression of these various brain disorders.
This Special Issue provides a platform for original research manuscripts and prospective reviews on the underlying pathogenic mechanisms of the organelle dysfunctions and the potential therapeutic strategies in the neurodevelopmental and neurological disorders.
Dr. Fanpeng Zhao
Guest Editor
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Keywords
- neurodevelopmental disorders
- neurological disorders
- neurodegeneration
- organelle crosstalk
- mitochondrial–ER contacts
- endolysosomal system
- autophagy
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