Special Issue "Therapeutic Applications of Extracellular Vesicles"
Deadline for manuscript submissions: closed (31 March 2020).
Interests: renal regeneration; kidney injury; angiogenesis; stem cells
Interests: acute kidney injury; chronic kidney disease; regenerative medicine; renal carcinomas
Interests: extracellular vesicles; cancer; tumour microenvironment; epithelial mesenchymal transition; infectious disease
Special Issues, Collections and Topics in MDPI journals
Extracellular vesicles (EVs) appear as a new promising cell-free therapy in regenerative medicine. EVs retain characteristics of the cell of origin, and those derived from stem cells may mimic their regenerative properties per se. EVs released by stem cells contain proteins and RNA species that act on recipient cells through a variety of mechanisms, resulting in tissue regeneration. In particular, EVs may sustain tissue proliferation, angiogenesis, and reduce apoptosis and inflammation. A large variety of preclinical data have shown the effect of EVs in acute and chronic tissue kidney, lung, hearth, liver, and brain injury, to name but a few.
The interest in EVs for therapeutic applications is related to their characteristics of safety, targeting ability, and multitarget properties. In particular, EVs derived from stem cells such as mesenchymal stromal cells are among the most studied EV sources. The possibility to engineer EVs and enrich their cargo opens new scenarios, such as delivery of bioactive molecules trough EVs from an autologous origin (serum, plasma, etc.) or from natural sources, such as milk, fruits, and vegetables.
The aim of this Special Issue is to provide an overview of the knowledge about the regenerative role of EVs, focusing on their therapeutic applications. This Special Issue will summarize the application of EVs in preclinical models of acute and chronic tissue injuries, comparing animal models, EV sources, including their subfractions, doses, routes of administration, and efficacy of treatment.
Prof. Benedetta Bussolati
Dr. Cristina Grange
Prof. Jameel M. Inal
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- extracellular vesicle fractions
- tissue injury
- stem cell derived EVs
- EV engineering
- EV sources
- EVs as drug delivery vehicles