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Special Issue "Organellar Calcium Signaling in Physiology and Pathophysiology"
Deadline for manuscript submissions: 15 December 2019.
Organellar function exists as a tightly regulated network of signalling cascades, each modulating different aspects of cellular physiology, from ATP synthesis to anti-oxidant defence systems and cell death. The function of these organelles is also influenced by the membrane composition and the structural organization and distribution of each organelle within the cell. However, despite the differences in the above-mentioned characteristics, organelles’ mode of action appears similar when they act as Ca2+-buffer and Ca2+-sensor factories. In response to various stimuli, organelles modulate Ca2+ signalling directly by importing Ca2+ via specific proteins embedded in the organellar membranes, or indirectly through the release of metabolites and messengers that can activate the Ca2+ signalling machinery. This intimate relationship between organelles and Ca2+ signalling lays the foundation for cellular decision-making, ultimately influencing cell survival. Therefore, given their importance in maintaining cellular homeostasis, any disturbance in the function of an organelle often results in the development of severe diseases, many of which have yet to be fully understood.
The aim of this Special Issue is to provide an overview summarizing our current knowledge regarding the underlying molecular mechanisms of organellar Ca2+ signalling in the context of normal cell physiology as well as disease, with special focus on the endoplasmic reticulum, lysosomes, and mitochondria.
Prof. Dr. Mohamed Trebak
Dr. Yassine El Hiani
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- organellar Ca2+
- endoplasmic reticulum