Special Issue "Mitochondrial Bioenergetics in Cancer Cell Biology"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (10 May 2018)
Prof. Dr. Giancarlo Solaini
Mitochondria are essential organelles in mammalian cells and play a key role in many processes, including oxidative phosphorylation (OXPHOS), aerobic metabolism of glucose, amino acids, and fatty acids, calcium and reactive oxygen species (ROS) homeostasis and signaling, and apoptosis. Tumor cells exhibit profound genetic, biochemical and histological differences compared to non-transformed cellular types. Many tumor cells predominantly convert glucose to lactate to generate Adenosine 5’-triphosphate (ATP) and biomass; however, glycolysis becomes the main metabolic pathway for the cell energy supply when mitochondria are impaired or when cells experience hypoxic conditions. Nonetheless, many evidence indicate the essential need of functioning mitochondria for tumor cells survival and tumor propagation.
Cancer cells have to acquire a flexible and variable metabolism to face and survive the many stress conditions such as hypoxia, low glucose and other nutrients deficiency, exposure to low pH and high ROS levels. Therefore, tumor cells have to reprogramme their metabolism at many levels and mitochondria take a pivotal part in this task, thus becoming essential to driving disease progression.
The aim of this Special Issue of Cells is to collect and publish high quality original papers, research communications, and reviews exploring the involvement of mitochondria in cancer cells metabolism adaptation particularly focusing on bioenergetics.
Prof. Dr. Alessandra Baracca
Prof. Dr. Giancarlo Solaini
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- oxidative phosphorylation
- respiratory chain complexes
- ATP synthase
- reactive oxygen/nitrogen species
- redox biology
- metabolism reprogramming
- metabolism regulation
- aminoacids metabolism
- fatty acids metabolism
- pyruvate/lactate metabolism
- mitochondria-related signaling pathway
- anti-tumor drug