Role and Importance of Tumor Suppressor Genes in Cancer
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 268
Special Issue Editor
Interests: breast cancer; obesity; racial disparity; microbiome; signaling; therapeutics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer initiation and metastatic progression is a tightly controlled multistep process and multiple factors play a role at every step. Loss of tumor suppressor genes (TSG) by deletion, mutation or functional inactivation by other mechanisms can lead to oncogenesis as TSGs play a pivotal role in cell proliferation, apoptosis, autophagy, migration, invasion and metastatic formation. TSGs can also modulate genomic integrity maintenance, cellular differentiation, DNA damage repair, and signaling pathway regulation. Of note, TSGs can be “gatekeepers” controlling processes involved in cancer initiation, progression and metastasis; or “caretakers” maintaining genomic stability and DNA repair mechanisms; or “landscapers” modulating the tumor microenvironment and potential metastatic niches. Recently, several microRNAs (miRs) and long non-coding RNAs (lncRNAs) have been implicated in their role in tumor suppression coining them as tumor suppressors. Several tumor suppressor genes, miRs and lncRNAs have been shown to play important roles in many cancer types and significant progress is being made to target them for therapeutic purposes. Also, certain environmental cues, infections and toxins have been shown to impact cancer progression by modulating tumor suppressors. Significant progress has been achieved to date; however, further research is still of great importance to better understand the role of tumor suppressor genes in cancer and their therapeutic targeting. For this Special issue of Cells, authors are invited to contribute both original research and review articles.
Prof. Dr. Dipali Sharma
Guest Editor
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