Genetic Predisposition to Hematological Malignancies
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 20 June 2026 | Viewed by 46
Special Issue Editor
Interests: acute leukemias; oncogenic fusions and chromosomal translocations; epigenetic regulation; cancer genomics and transcriptomics; precision medicine in hematology
Special Issue Information
Dear Colleagues,
Genetic predisposition critically influences the risk and clinical course of hematological malignancies. A growing body of evidence highlights the contribution of germline variants to leukemia susceptibility, often manifesting through family history, congenital anomalies, unexplained cytopenias, or unusual responses to therapy. These variants may arise de novo but in many cases are inherited and passed down over generations. Most predisposition syndromes follow an autosomal dominant inheritance with variable penetrance, while autosomal recessive and X-linked conditions, such as bone marrow failure and immune deficiency syndromes, also confer a substantial risk of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Unlike sporadic cases, germline predisposition affects all cells of the body and therefore has far-reaching clinical and familial implications. This Special Issue will bring together recent advances in the field, from molecular mechanisms to diagnostic strategies, and explore the implications for genetic counseling, patient care, and precision medicine.
Dr. Danika Di Giacomo
Guest Editor
Manuscript Submission Information
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Keywords
- leukemia predisposition
- germline variants
- inherited syndromes
- myelodysplastic syndrome (MDS)
- acute myeloid leukemia (AML)
- precision medicine
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