Immunometabolism and Cancer: Localized and Systemic Metabolic Interactions That Shape the Evolution of Malignancy
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".
Deadline for manuscript submissions: closed (1 December 2023) | Viewed by 428
Special Issue Editor
Special Issue Information
Dear Colleagues,
Immunometabolism plays a central role in anticancer immune responses. Metabolic shifts have been described for the cells that are involved in both innate and adaptive immune response and that are required for mounting an appropriate anticancer immune response. Besides the important and obvious function of metabolic supply to provide energy and biomass to sustain increased proliferation, cytokine secretion, and cytotoxic function, it has become clear that the abundance of certain metabolites such as alpha-ketoglutarate and succinate can also regulate the cell fate of immune cells, thus modulating the evolution of anticancer immune responses.
An additional layer of complexity is added by the heterogeneous and fluctuating concentrations of nutrients and oxygen in the tumor microenvironment, which limit the availability of essential metabolites and set the stage for fierce competition between cancer and immune cells, or even between different classes of immune cells. In addition, the secretion of metabolites such as lactic acid by cancer cells can interfere with the function of anti-cancer immune cells. Finally, systemic metabolism is likely to exert a profound effect on the proper function of the immune system and therefore on anticancer immune responses. The intricacies and interconnections of local and systemic metabolic interactions between the immune system and cancer have only begun to be unraveled.
This Special Issue will focus on the role of metabolism in anticancer immune responses, with particular interest in local and systemic metabolic interactions that can affect the immune system, and aims to highlight new ways to improve anticancer immunotherapies by modulating immunometabolism.
Dr. Claudio Scafoglio
Guest Editor
Manuscript Submission Information
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Keywords
- immunometabolism
- anticancer immune response
- glucose metabolism
- amino acid metabolism
- lipid metabolism
- mitochondrial metabolism
- cytotoxic T cells
- helper T cells
- macrophages
- dendritic cells
- natural killer cells
- immunotherapy
- CAR-T
- immune checkpoint inhibitors
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