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Biomarkers of Ovarian Cancer Progression

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Biomarkers".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 788

Special Issue Editor


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Guest Editor
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT 06510, USA
Interests: ovarian cancer; tumor initiation; chemoresistance; metastasis; p53; ferroptosis; exosomes; nanoparticles

Special Issue Information

Dear Colleagues,

The clinical management of ovarian cancer is highly challenging for several reasons, such as high rates of late diagnosis and tumor recurrence. The five-year survival rate of ovarian cancer patients, which is about 45% in general and 30% for patients diagnosed with late-stage tumors, has changed very little over the past decade. Most patients undergo debulking surgery and platinum–paclitaxel combination chemotherapy. During and after the initial treatment, prognostic biomarkers with sensitivity and specificity are crucial when it comes to monitoring patients’ response to treatment and the progression or recurrence of ovarian cancer. Serum and tissue-based biomarkers have been investigated with the hope of developing clinical tools to assess or predict the development of ovarian cancer. Over the past ten years, many researchers have focused their efforts on researching this field, aiming to transform the treatment of patients with ovarian cancer and improve their survival rate.

In this Special Issue of Cancers, we invite experts in the field to contribute research papers that address our current understanding and challenges in the development of potential biomarkers for detecting the progression of ovarian cancer.

Dr. Yang Yang-Hartwich
Guest Editor

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Keywords

  • ovarian cancer
  • biomarkers
  • prognosis
  • blood biomarkers
  • tissue biomarkers
  • tumor progression
  • treatment response

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Published Papers (1 paper)

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Review

16 pages, 276 KiB  
Review
Personalized Treatment in Ovarian Cancer: A Review of Disease Monitoring, Biomarker Expression, and Targeted Treatments for Advanced, Recurrent Ovarian Cancers
by Victoria M. Ettorre, Abdelrahman AlAshqar, Namrata Sethi and Alessandro D. Santin
Cancers 2025, 17(11), 1822; https://doi.org/10.3390/cancers17111822 - 30 May 2025
Viewed by 535
Abstract
Background/Objectives: Ovarian cancer is the most lethal gynecologic malignancy due to its late diagnosis, aggressive disease course, and high likelihood of recurrence. In the last few years, with the advent of high-throughput genomic methodologies, our understanding of ovarian cancer genetics and biology [...] Read more.
Background/Objectives: Ovarian cancer is the most lethal gynecologic malignancy due to its late diagnosis, aggressive disease course, and high likelihood of recurrence. In the last few years, with the advent of high-throughput genomic methodologies, our understanding of ovarian cancer genetics and biology has grown. In this review, we discuss current monitoring techniques, as well as biomarker-directed therapies, recently developed for ovarian cancer treatment. Methods: The primary literature and review articles were obtained through PUBMED searches of “ovarian cancer”, “biomarkers”, “CA125”, “circulating tumor DNA”, “BRCA”, “HER2”, “TROP2”, and “FOLR1.” Results and Conclusions: The detection and quantification of CA125, a protein biomarker, remains the primary test used in the clinic for ovarian cancer diagnosis and monitoring. However, liquid biopsy techniques involving circulating tumor DNA, used alone or in combination with CA125, are increasingly used to enhance diagnostic accuracy and provide a more comprehensive picture of tumor genomic changes, including single-nucleotide variants, copy number variations, and epigenetic alterations. In the last few years, the use of BRCA, HER2, TROP2, and FOLR1 as biomarkers for targeted treatment has demonstrated promising results, both preclinically and clinically. The detection of BRCA1/2 mutations is routinely used as a strong predictor of response to PARP inhibitors, while HER2, TROP2, and FOLR1 expressions have emerged as primary targets for the treatment of recurrent ovarian cancer patients using novel antibody–drug conjugates (ADCs). Full article
(This article belongs to the Special Issue Biomarkers of Ovarian Cancer Progression)
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