Autophagy and Therapy Resistance in Cancers
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 1998
Special Issue Editors
Interests: autophagy; cancer plasticity and stemness; chemoresistance; intratumoral heterogeneity; lymphoma; myc; oncogenic tyrosine kinases
Special Issues, Collections and Topics in MDPI journals
Interests: hypoxia; autophagy; extracellular vesicles; unfolded protein response
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Macroautophagy (or autophagy) is a highly evolutionarily conserved process that carries important homeostatic functions in response to various stressful stimuli. While its roles in drug resistance in cancers are far from clear, there is accumulating evidence that autophagy promotes chemoresistance in many cancer cell types and experimental models. Additionally, autophagy supports the survival of hypoxic cells, which further limits the effectiveness of chemo- and/or radiotherapy. The use of autophagy inhibitors such as chloroquine and gene silencing of specific autophagy-related genes have been shown to sensitize cancer cells to chemotherapeutic agents and radiation. There are over 30 active clinical trials based on the premise that the inhibition of autophagy can increase the efficacy of cancer treatments. One of the focuses of this issue is to further our understanding of the molecular basis underlying autophagy-related therapy resistance and to explore new ways that synergize with this process to kill cancer cells more efficiently. Studies of the interplay between the autophagy pathway and the other key cellular processes can probably shed light into how autophagy can often exert dual roles in different contexts. As recent studies have revealed the link between autophagy and stemness, it will be of interest to examine how autophagy may contribute to the high level of chemoresistance in cancer stem-like cells.
Prof. Dr. Raymond Lai
Dr. Kasper M. Rouschop
Guest Editors
Manuscript Submission Information
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Keywords
- autophagy
- chemotherapy
- radiotherapy
- hypoxia
- senescence
- cancer stem cells
- tumor microenvironment
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