Extracellular Metabolic Cues in the Regulation of Tumor Immune Environment
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: closed (15 February 2024) | Viewed by 654
Special Issue Editors
Interests: cancer metabolism; mitochondria; cancer-associated fibroblasts; lactate metabolism; prostate cancer
Special Issue Information
Dear Colleagues,
The tumor microenvironment (TME) imposes several obstacles to the proper function of immune cells, including a metabolically challenging and immunosuppressive microenvironment. The increased metabolic activity of tumor cells can lead to the metabolic competition for and depletion of key nutrients required by immune cells and the accumulation/release of certain metabolites such as lactates, succinates, and fatty acids. These act as both metabolites and/or hormone-like molecules, triggering the activation of metabolic pathways and/or intracellular signaling cascades, accordingly to their environmental concentration and their binding to the specific transporter or receptor.
Thus, understanding the role of these molecules in metabolic interplay and/or sensing between tumor and immune cells could open avenues for highlighting new vulnerable metabolic and signaling pathways and consequently novel therapeutic strategies to integrate with the existing therapy interventions.
In this Special Issue, original articles and reviews are welcome to discuss which metabolic pathways/signaling impact on the function of different immune cell subsets in localized and metastatic diseases and how these molecular profiles differ in the TME. Finally, the issue will highlight the new efforts to target metabolism or metabolite-sensing for the purpose of increasing antitumor immune responses and improving the efficacy of cancer immunotherapies.
Dr. Luigi Ippolito
Prof. Dr. Paola Chiarugi
Guest Editors
Manuscript Submission Information
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Keywords
- metabolic drugs
- T cells
- metabolic cross-talk
- immune checkpoint inhibitors
- immunotherapy resistance
- cancer metastasis
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