Predictive Theoretical and Experimental Models of Breast Cancer Metastasis: Toward Optimal Therapeutic Design
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 207
Special Issue Editor
Special Issue Information
Dear Colleagues,
Despite continued innovations in cancer treatment, metastasis still accounts for a majority of cancer-associated morbidity and mortality. Understanding the biophysical mechanisms underpinning cancer progression and the establishment of metastatic disease is therefore critical to the development of novel therapeutic strategies. Predicting such biological mechanisms and their relevance to cancer progression maximally benefits from both theoretical prediction and empirical follow-up.
A number of relevant phenomena have gained interest in both research communities, including:
- The role of phenotypic transitions in facilitating the establishment of metastatic sites, including the epithelial–mesenchymal transition;
- Co-evolution between the adaptive immune system and evading cancer population;
- Molecular and cellular determinants of the tumor microenvironment;
- The role of circulating tumor cells and cancer dormancy in primary cancer dissemination.
This Special Issue aims to provide an overview of theoretical and experimental efforts that describe the role of the above topics in breast cancer progression, with an emphasis on approaches that can inform optimal therapeutic design.
I look forward to receiving your contributions.
Dr. Jason Thomas George
Guest Editor
Manuscript Submission Information
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Keywords
- breast cancer
- cancer metastasis
- predictive cancer modeling
- optimal cancer therapies
- tumor microenvironment
- cellular dormancy
- phenotypic transitions
- tumor–immune interaction
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