Updates on Epigenetics of Brain Tumor

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".

Deadline for manuscript submissions: closed (30 November 2024) | Viewed by 1414

Special Issue Editor


E-Mail Website
Guest Editor
1. University Institute of Oncology of Asturias (IUOPA), University of Oviedo, 33006 Oviedo, Spain
2. Health Research Institute of Asturias (ISPA), 33011 Oviedo, Spain
Interests: epigenomics; cancer; aging; proteomics; chromatin signatures; biomarkers; precision medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Primary malignant brain tumors can affect people of any age, including children, and are usually highly aggressive as well as heterogeneous cancers. Currently, epigenetic alterations are a well-established hallmark of these cancers, though there is still a critical need to gain a deeper understanding of their specific roles during tumorigenesis. This Special Issue, dedicated to the epigenetics of malignant brain tumors, with a special focus on glioblastoma multiforme, will highlight the causes and functional consequences of a dysregulated epigenetic landscape in these frequently fatal cancers, covering both basic and more clinical aspects. Original experimental and clinical studies, as well as reviews, studying the plethora of altered epigenetic mechanisms (such as DNA methylation/hydroxymethylation and histone post-translational modifications) in cancerous brain tumors are invited. Finally, how epigenetic players could represent clinical targets, in addition to how their modulation could inform novel therapeutic strategies, and future challenges to overcome for spurring their translation into clinical oncology will also be discussed.

Dr. Virginia López Martínez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epigenetics
  • glioma
  • omics analyses
  • 5-hydroxymethylcytosine
  • DNA methylation
  • histones
  • chromatin signatures
  • biomarkers
  • precision medicine

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

17 pages, 1101 KiB  
Review
Epitranscriptomics in the Glioma Context: A Brief Overview
by Pablo Santamarina-Ojeda, Agustín F. Fernández and Mario F. Fraga
Cancers 2025, 17(4), 578; https://doi.org/10.3390/cancers17040578 - 8 Feb 2025
Viewed by 748
Abstract
Epitranscriptomics, the study of chemical modifications in RNA, has emerged as a crucial field in cellular regulation, adding another layer to the established landscape of DNA- and histone-based epigenetics. A wide range of RNA modifications, including N6-methyladenosine, pseudouridine, and inosine, have [...] Read more.
Epitranscriptomics, the study of chemical modifications in RNA, has emerged as a crucial field in cellular regulation, adding another layer to the established landscape of DNA- and histone-based epigenetics. A wide range of RNA modifications, including N6-methyladenosine, pseudouridine, and inosine, have been identified across nearly all RNA species, influencing essential processes such as transcription, splicing, RNA stability, and translation. In the context of brain tumors, particularly gliomas, specific epitranscriptomic signatures have been reported to play a role in tumorigenesis. Despite growing evidence, the biological implications of various RNA modifications remain poorly understood. This review offers an examination of the main RNA modifications, the interplay between modified and unmodified molecules, how they could contribute to glioma-like phenotypes, and the therapeutic impact of targeting these mechanisms. Full article
(This article belongs to the Special Issue Updates on Epigenetics of Brain Tumor)
Show Figures

Figure 1

Back to TopTop