Neurocognitive Deficits and Remediation in Severe Mental Illness: Mechanisms and Treatments
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuropsychiatry".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 48
Special Issue Editor
Interests: neurocognitive impairments in psychosis and schizophrenia; biomarkers of severe psychopathology; pathophysiology of cognition in patients with psychosis or at high risk for psychosis; neurophysiological response to cognitive interventions
Special Issue Information
Dear Colleagues,
Brain Sciences is pleased to announce a forthcoming Special Issue dedicated to advancing our understanding of neurocognitive deficits in severe mental illness (SMI) and the development of effective remediation strategies. Cognitive dysfunction is a core feature of conditions such as schizophrenia, schizoaffective disorder, and bipolar disorder, profoundly influencing functional outcomes and recovery trajectories. Identifying underlying mechanisms and implementing targeted treatments are central to improving quality of life and long-term prognosis for individuals living with SMI.
This Special Issue will bring together cutting-edge research, theoretical frameworks, clinical trials, and translational perspectives that explore the mechanisms driving cognitive impairment, as well as evidence-based approaches to remediation. By highlighting both neurobiological underpinnings and innovative treatment modalities, we aim to provide an integrated perspective on current challenges and future directions in the field.
We invite submissions of original research, systematic reviews, meta-analyses, and clinical case studies addressing topics such as the following:
- Mechanisms underlying neurocognitive deficits in severe mental illness (e.g., neuropsychological, neural circuitry, neurochemical, genetic, developmental, and environmental factors);
- Cognitive domains most affected in SMI and their relationship to functional outcomes;
- Evidence-based cognitive remediation therapies and their neural and behavioral mechanisms;
- Integration of pharmacological and psychosocial interventions to enhance cognitive functioning;
- Innovative technologies for remediation (e.g., digital platforms, virtual reality, neurostimulation);
Translational and policy perspectives on implementing cognitive remediation in clinical care.
Dr. Veronica B. Perez
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
Psychosis/Schizophrenia;
Neurocognition/neurophysiology;
Psychosocial Function;
Cognitive remediation;
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