Fresh Insights into Dravet Syndrome
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Molecular and Cellular Neuroscience".
Deadline for manuscript submissions: closed (9 December 2020) | Viewed by 227
Special Issue Editors
Special Issue Information
Dravet syndrome, also known as severe myoclonic epilepsy of infancy, is a type of epilepsy involving febrile and afebrile characteristics, generalized tonic-clonic seizures, severe postnatal mortality, and autism-like phenotypes. Dravet syndrome is a genetic disorder with 80% of patients displaying mutations of the Scn1a gene, which encodes the sodium channel alpha subunit. Studies using mouse models suggest that behavioral abnormalities in Dravet syndrome are caused by a decrease in a product of the Scn1a gene, the NaV1.1 protein, in inhibitory neurons.
Dravet syndrome is antiepileptic-drug-resistant, and there is currently no effective treatment to completely cure its symptoms. Recent studies suggest that cannabis administration and oligonucleotide treatment can reduce the occurrence of seizures. However, it is necessary to develop more effective treatments through the discovery of new chemical compounds and the development of new (or old) technologies, such as gene editing and gene replacement therapy.
This Special Issue of Brain Sciences aims to present a collection of preclinical and clinical studies related to the development of treatment for Dravet's syndrome, as well as studies that provide a broad understanding of the mechanisms of this condition, from the molecular to the behavioral level.
Dr. Yosuke Niibori
Guest Editor
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