Deep Brain Stimulation for Cognitive Dysfunction and Psychiatric Disorders

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurotechnology and Neuroimaging".

Deadline for manuscript submissions: closed (25 September 2024) | Viewed by 2185

Special Issue Editors


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Guest Editor
Department of Basic & Clinical Neuroscience, King's College London, London, UK
Interests: deep brain stimulation; Parkinson's disease; movement disorders; neurooncology; epilepsy; chronic pain; spine surgery

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Guest Editor
Pain and Functional Neurosurgery Clinic, Sao Paulo, Brazil
Interests: deep brain stimulation; neuropsychiatric disorders; neurosurgery

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Guest Editor
Functional Neurosurgery Department, Universidade de Caxias do Sul, Caxias do Sul, Brazil
Interests: neurology; neuroanatomophysiology; neurosurgery; deep brain stimulation

Special Issue Information

Dear Colleagues,

Deep Brain Stimulation (DBS) is a surgical procedure that involves implanting electrodes that deliver electrical impulses to specific areas of the brain, modulating neuronal activity in order to treat certain medical conditions. The clinical use of DBS is among the most important advances in the clinical neurosciences in recent decades. Although it has primarily been used to treat movement disorders, such as Parkinson’s disease, its novel potential indications in both neurological and psychiatric disorders are undergoing active investigation. This Special Issue aims to collect clinical and pre-clinical studies, investigating the application of DBS in the management of cognitive and neuropsychiatric disorders, as well as future directions in the DBS field. A deeper understanding of the working mechanisms of DBS, its limitations, and potential applications in the management of cognitive and neuropsychiatric disorders will help to elaborate the future role of this technology in treating the most challenging diseases affecting the human brain.

Dr. Luciano Furlanetti
Dr. Eduardo Joaquim Lopes Alho
Dr. Paulo Roberto Franceschini
Guest Editors

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Keywords

  • deep brain stimulation
  • psychiatry
  • cognitive disorders
  • neuroscience
  • technology

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Published Papers (1 paper)

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Review

17 pages, 306 KiB  
Review
Biomarkers: The Key to Enhancing Deep Brain Stimulation Treatment for Psychiatric Conditions
by Guillermo J. Bazarra Castro, Vicente Casitas, Carlos Martínez Macho, Alejandra Madero Pohlen, Amelia Álvarez-Salas, Enrique Barbero Pablos, Jose A. Fernández-Alén and Cristina V. Torres Díaz
Brain Sci. 2024, 14(11), 1065; https://doi.org/10.3390/brainsci14111065 - 26 Oct 2024
Viewed by 1683
Abstract
Background: Deep brain stimulation (DBS) is currently a promising technique for psychiatric patients with severe and treatment-resistant symptoms. However, the results to date have been quite heterogeneous, and the indications for psychosurgery with DBS remain in an experimental phase. One of the major [...] Read more.
Background: Deep brain stimulation (DBS) is currently a promising technique for psychiatric patients with severe and treatment-resistant symptoms. However, the results to date have been quite heterogeneous, and the indications for psychosurgery with DBS remain in an experimental phase. One of the major challenges limiting the advancement of DBS in psychiatric disorders is the lack of objective criteria for diagnosing certain conditions, which are often based more on clinical scales rather than measurable biological markers. Additionally, there is a limited capacity to objectively assess treatment outcomes. Methods: This overview examines the literature on the available biomarkers in psychosurgery in relation to DBS, as well as other relevant biomarkers in psychiatry with potential applicability for this treatment modality. Results: There are five types of biomarkers: clinical/behavioral, omic, neuroimaging, electrophysiological, and neurobiochemical. The information provided by each biomarker within these categories is highly variable and may be relevant for diagnosis, response prediction, target selection, program adjustment, etc. Conclusions: A better understanding of biomarkers and their applications would allow DBS in psychosurgery to advance on a more objective basis, guided by the information provided by them and within the context of precision psychiatry. Full article
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