Nanocarbon-Based Biosensors

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 3955

Special Issue Editors


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Guest Editor
Department of Microbiology and Immunology, School of Medicine, University of Nevada, Reno, NV 89557, USA
Interests: nanoparticles research; biosensors; fluorescent probes; electrochemistry-based immunoassay; supramolecular chemistry; artificial antibodies
Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
Interests: functional hybrid nanomaterials; two-dimensional (2D) nanomaterials; thin film electronic devices; sensors; inorganic/organic nanoscale electronics

E-Mail Website
Guest Editor
Department of Microbiology and Immunology, School of Medicine, University of Nevada, Reno, NV 89557, USA
Interests: immunological/microbiological research; biomedical engineering; biosensors; fluorescence probes

Special Issue Information

Dear Colleagues,

Nanocarbon materials with different dimensions, including fullerenes, carbon dots, carbon nanotubes, graphene and graphene oxides, nanodiamonds, etc., have attracted enormous research interest due to their unique structural, physical, chemical, and electronic properties. Nanocarbon is one of the most intensively studied nanomaterials and has been widely used in many different fields, including energy conversion and storage, environment protection, catalysis, chemical and biochemical sensors, and biomedicine.

Biosensors are analytical devices that detect the presence of an analyte of interest, such as a biologically important small molecule (e.g., glucose and adenosine triphosphate), a biomolecule (e.g., peptides, DNAs, and enzymes), or a microorganism (e.g., viruses, bacteria, and cancer cells). Biosensors consist of three elements: a sensitive biological element that recognizes a specific analyte and produces a signal, a signal transduction element that transforms one signal into another, and a reading device that measures the signal. Various biosensors have been developed based on enzymes, tissues, antibodies, DNAs, etc. and widely used in the field of food safety, environmental research and protection, security and defense, biomedical research, and life sciences. They provide better stability, sensitivity, and feasibility compared to traditional methods.

Applications of nanocarbon materials in biosensors provide opportunities for developing a new generation of biosensors with improved mechanical, electrochemical, or optical properties, and overall performance of the biosensors. Nanocarbon-based biosensors can be classified into the following four categories according their transduction mechanism: (1) electronic biosensors using nanocarbon or hybrid nanocarbon-based composites as field-effect transistors; (2) electrochemical biosensors employing nanocarbon-modified electrodes; (3) optical and visual biosensors based on colorimetric detection, fluorescence quenching, Forster resonance energy transfer (FRET), and chemiluminescence; and (4) plasmonic biosensors using nanocarbon as a plasmonic layer or a sensitivity-enhancement material.

This Special Issue is dedicated to cutting-edge research and development based on nanocarbon materials that advance the field of biosensors. Original research articles, short communications, and reviews are all welcome.

Dr. Liming Huang
Dr. Kai Xiao
Dr. Kenneth Hunter
Guest Editors

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Keywords

  • nanomaterials
  • nanocarbon
  • fullerenes
  • carbon dots
  • carbon nanotubes
  • graphene
  • graphene oxides
  • biosensors
  • biosensing
  • bioimaging
  • electrochemical
  • fluorescence
  • chemiluminescence
  • FRET
  • fluorescence quenching
  • plasmonics

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Published Papers (1 paper)

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Research

13 pages, 2263 KiB  
Article
Label-Free Amperometric Immunosensor Based on Versatile Carbon Nanofibers Network Coupled with Au Nanoparticles for Aflatoxin B1 Detection
by Yunhong Huang, Fei Zhu, Jinhua Guan, Wei Wei and Long Zou
Biosensors 2021, 11(1), 5; https://doi.org/10.3390/bios11010005 - 24 Dec 2020
Cited by 23 | Viewed by 3469
Abstract
Facile detection methods for mycotoxins with high sensitivity are of great significance to prevent potential harm to humans. Herein, a label-free amperometric immunosensor based on a 3-D interconnected carbon nanofibers (CNFs) network coupled with well-dispersed Au nanoparticles (AuNPs) is proposed for the quantitative [...] Read more.
Facile detection methods for mycotoxins with high sensitivity are of great significance to prevent potential harm to humans. Herein, a label-free amperometric immunosensor based on a 3-D interconnected carbon nanofibers (CNFs) network coupled with well-dispersed Au nanoparticles (AuNPs) is proposed for the quantitative determination of aflatoxin B1 (AFB1) in wheat samples. In comparison to common carbon nanotubes (CNTs), the CNFs network derived from bacterial cellulose biomass possesses a unique hierarchically porous structure for fast electrolyte diffusion and a larger electrochemical active area, which increases the peak current of differential pulse voltammetry curves for an immunosensor. Combined with AuNPs that are incorporated into CNFs by using linear polyethyleneimine (PEI) as a soft template, the developed Au@PEI@CNFs-based immunosensor showed a good linear response to AFB1 concentrations in a wide range from 0.05 to 25 ng mL−1. The limit of detection was 0.027 ng mL−1 (S/N = 3), more than three-fold lower than that of an Au@PEI@CNTs-based sensor. The reproducibility, storage stability and selectivity of the immunosensor were proved to be satisfactory. The developed immunosensor with appropriate sensitivity and reliable accuracy can be used for the analysis of wheat samples. Full article
(This article belongs to the Special Issue Nanocarbon-Based Biosensors)
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