Microfluidics and MEMS for Diagnostics and Biomedical Applications—2nd Edition

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: closed (30 May 2025) | Viewed by 1534

Special Issue Editor


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Guest Editor
Institute for Health Innovation & Technology (iHealthtech), National University of Singapore, Singapore 117599, Singapore
Interests: organ on a chip; drug screening; cell mechanobiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The recent pandemic has revealed the importance of innovation in healthcare as the best strategy for preparing for crises. Medical devices that target, in particular, point-of-care and low-resource healthcare settings become of paramount importance.

Recent advances in microfabrication, microfluidic, and microelectromechanical systems (MEMS) technologies have opened numerous new avenues in healthcare applications. The ability to create complex nano-and micro-scale structures, employing various low-cost and biocompatible materials, has enabled unrestricted geometrical features. In addition, the integration of sensing elements, including electrical components (e.g., gold/silver/platinum/graphene-based electrodes), optical, wireless, and data acquisition modules within the microfluidic network has attracted notable interest in the medical device industry for health-monitoring applications.

This Special Issue will highlight the new advances and trends in this prominent field and technology with an emphasis on the role of microfluidics and MEMS technologies in diagnostics and related medical applications, as well as how the engineering principle can be used to meet industrial/clinical needs. In addition, the topic will highlight the challenges and opportunities of these biomedical devices.

We invite researchers working in this area to submit full-length research papers, communications, and review articles to meet the goal of this research topic.

Topics include:

  • Microfluidic design and simulation for microfluidic-based biomedical devices;
  • Fabrication materials;
  • Device fabrication techniques (e.g., lithography, soft lithography, micromachining, 3D printing, etc.);
  • MEMS-based medical devices;
  • Rapid prototyping;
  • Sensor integration;
  • Vital signs monitoring;
  • Implantable devices;
  • Wearable devices;
  • Drug delivery with microneedles and patches. 

Dr. Xiaoyan Liu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microfluidics
  • microfabrication
  • microelectromechanical systems
  • diagnostics
  • biosensors
  • micromachining
  • integration
  • implantable
  • wearable

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Published Papers (1 paper)

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Research

18 pages, 2667 KiB  
Communication
Parylene-C Modified OSTE Molds for PDMS Microfluidic Chip Fabrication and Applications in Plasma Separation and Polymorphic Crystallization
by Muyang Zhang, Haonan Li, Xionghui Li, Zitong Ye, Qinghao He, Jie Zhou, Jiahua Zhong, Hao Chen, Xinyi Chen, Yixi Shi, Huiru Zhang, Lok Ting Chu and Weijin Guo
Biosensors 2025, 15(6), 388; https://doi.org/10.3390/bios15060388 - 16 Jun 2025
Viewed by 584
Abstract
This work presents a novel microfabrication process that addresses the interference of thiol groups on off-stoichiometry thiolene (OSTE) surfaces with the curing of polydimethylsiloxane (PDMS) by integrating the high-performance polymer Parylene-C. The process utilizes a Parylene-C coating to encapsulate the active thiol groups [...] Read more.
This work presents a novel microfabrication process that addresses the interference of thiol groups on off-stoichiometry thiolene (OSTE) surfaces with the curing of polydimethylsiloxane (PDMS) by integrating the high-performance polymer Parylene-C. The process utilizes a Parylene-C coating to encapsulate the active thiol groups on the OSTE surface, enabling precise replication of PDMS microstructures. Based on this method, PDMS micropillar arrays and microwell arrays were successfully fabricated and applied in passive plasma separation and polymorphic crystal formation, respectively. The experimental results demonstrate that the plasma-separation chip efficiently isolates plasma from whole-blood samples with varying hematocrit (HCT) levels, achieving a separation efficiency of up to 57.5%. Additionally, the microwell array chip exhibits excellent stability and controllability in the growth of salt and protein crystals. This study not only provides a new approach for microfabricating microfluidic chips, but also highlights its potential applications in biomedical diagnostics and materials science. Full article
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