Trends in AI-Enhanced Optical Biosensors
A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".
Deadline for manuscript submissions: 30 November 2026
Special Issue Editors
Interests: biosensors; optical; SPR
Interests: enzymatic biosensors; optical substrates; hydrolases; cytochrome P450 enzymes; transferases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues，
Optical biosensors offer exceptional capabilities for label-free, real-time detection of biomolecules but face persistent challenges in complex data interpretation, sensor variability, and the extraction of subtle signals from noisy backgrounds. The integration of artificial intelligence (AI) is emerging as a transformative trend, moving these sensors from simple detection tools to intelligent analytical systems. This evolution is primarily driven by the application of machine learning (ML) and deep learning (DL) algorithms across three key areas: advanced data processing for denoising, feature extraction, and direct concentration prediction from complex optical spectra; sensor design and optimization through inverse design of nanophotonic structures and performance prediction; and the creation of fully integrated smart sensing systems that enable real-time decision-making and multiplexed analysis. AI-enhanced optical biosensors demonstrate significant improvements in sensitivity, specificity, and limit of detection, particularly in challenging real-world matrices like blood serum or environmental samples. The synergy between AI and optical biosensing is poised to unlock new frontiers in personalized medicine, on-site diagnostics, and fundamental biological research.
We welcome original research articles, comprehensive reviews, and communications that contribute to the development of robust biomedical sensing platforms that can be readily translated into clinical applications.
Dr. Chunyan Wang
Prof. Dr. Guang-Bo Ge
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.
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Keywords
- optical biosensors
- Artificial intelligence (AI)
- machine learning
- data analysis
- intelligent diagnostics
- nanophotonics
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