Organic Two-Dimensional Material: Synthesis and Biosensing Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 2479

Special Issue Editor


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Guest Editor
Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, China
Interests: organic two-dimensional materials; thin film materials; field effect transistor; memory storage device; photodetector

Special Issue Information

Dear Colleagues,

As an analogue of graphene and other closely related inorganic two-dimensional (2D) materials such as transition-metal dichalcogenides, 2D organic materials including 2D covalent organic frameworks, 2D metal-organic frameworks, 2D polymers and supramolcular polymers etc have attracted great attention of researchers. Their periodic porous structure, ultrahigh surface areas, well designable topology and electronic structures endow them great potential in applications in sensing devices. This special issue aims to summarize the recent progress in synthesis and biosensing application of 2D organic materials, including the design and synthesis of 2D organic materials toward the application of sensing device, such as the functionalization of 2D organic materials, strategies toward the synthesis of high-quality thin films, application of these materials in sensing devices toward biorelevant targets from ions and biomolecules to proteins, viruses, and even bacteria and cells etc. 

Prof. Dr. Shengbin Lei
Guest Editor

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Keywords

  • organic two-dimensional materials
  • biosensor
  • thin films
  • field effect transistors
  • synthesis

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Published Papers (2 papers)

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Research

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11 pages, 4414 KiB  
Article
Photoelectric Multi-Signal Output Sensor Based on Two-Dimensional Covalent Organic Polymer Film Modified by Novel Aggregation-Induced Emission Probes
by Yaru Song, Guoling Wu, Enbing Zhang, Guangyuan Feng, Shengbin Lei and Lingli Wu
Biosensors 2024, 14(6), 312; https://doi.org/10.3390/bios14060312 - 18 Jun 2024
Viewed by 1568
Abstract
Optical sensors, especially fluorescence sensors, have been widely used because of their advantages in sensing, such as the high sensitivity, good selectivity, no radiation source, and easy operation. Here, we report an example of fluorescence sensing based on two-dimensional (2D) covalent organic polymers [...] Read more.
Optical sensors, especially fluorescence sensors, have been widely used because of their advantages in sensing, such as the high sensitivity, good selectivity, no radiation source, and easy operation. Here, we report an example of fluorescence sensing based on two-dimensional (2D) covalent organic polymers and highlight that the material can achieve a fast response and multi-signal output. This 2DPTPAK+TAPB-based sensor can quickly detect aromatic hydrocarbons and Fe3+ by the fluorescence signal or electrical resistance signal. Full article
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Review

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28 pages, 3972 KiB  
Review
Doping Detection Based on the Nanoscale: Biosensing Mechanisms and Applications of Two-Dimensional Materials
by Jingjing Zhao, Yu Wang and Bing Liu
Biosensors 2025, 15(4), 227; https://doi.org/10.3390/bios15040227 - 3 Apr 2025
Viewed by 473
Abstract
Doping undermines fairness in sports and threatens athlete health, while conventional detection methods like LC-MS and GC-MS face challenges such as complex procedures, matrix interferences, and lengthy processing times, limiting on-site applications. Two-dimensional (2D) materials, including graphene, MoS2, and metal–organic frameworks [...] Read more.
Doping undermines fairness in sports and threatens athlete health, while conventional detection methods like LC-MS and GC-MS face challenges such as complex procedures, matrix interferences, and lengthy processing times, limiting on-site applications. Two-dimensional (2D) materials, including graphene, MoS2, and metal–organic frameworks (MOFs), offer promising solutions due to their large surface areas, tunable electronic structures, and special interactions with doping agents, such as hydrogen bonding, π-π stacking, and electrostatic forces. These materials enable signal transduction through changes in conductivity or fluorescence quenching. This review highlights the use of 2D materials in doping detection. For example, reduced graphene oxide–MOF composites show high sensitivity for detecting anabolic steroids like testosterone, while NiO/NGO nanocomposites exhibit strong selectivity for stimulants like ephedrine. However, challenges such as environmental instability and high production costs hinder their widespread application. Future efforts should focus on improving material stability through chemical modifications, reducing production costs, and integrating these materials into advanced systems like machine learning. Such advancements could revolutionize doping detection, ensuring fairness in sports and protecting athlete health. Full article
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