Special Issue "Visualizing the Genome"

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Structure and Dynamics".

Deadline for manuscript submissions: 29 February 2020.

Special Issue Editor

Dr. Srinjan Basu
E-Mail Website
Guest Editor
Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK
Interests: genome organisation; chromosome conformation capture; single-molecule imaging; stem cells; embryo development

Special Issue Information

Dear Colleagues,

Genome organization plays an important role in biological processes such as cellular differentiation during development. Mis-regulation of proteins that govern genome architecture is often related to the progression of diseases, such as cancer or neurological disorders. In the past decade, advances in high-resolution imaging approaches, such as stimulated emission depletion (STED) and single-molecule localisation microscopy (SMLM), have led to the imaging of genome architecture well below the diffraction limit of light, allowing us to now dissect previously inaccessible dynamics critical to genome function. These developments have been complemented by approaches that allow us to determine genome architecture at the single-cell level based on the proximity of DNA sequences, such as single-cell chromosome conformation capture Hi-C. By bringing together these approaches, it has become clear that genome organisation varies considerably from cell to cell but that there are also emerging rules that govern this organisation, such as liquid–liquid phase separation of specific genomic sequences in the nucleus.

This Special Issue will present reviews and original articles covering advances in imaging, DNA proximity-based technology, and other approaches that improve our ability to visualize genome organization at the single-cell level, as well as how these advances have improved our understanding of the way genomes are organized.

Dr. Srinjan Basu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • imaging
  • single-molecule
  • high-resolution
  • chromatin
  • genome
  • chromosome conformation capture
  • fluorescence microscopy
  • single-cell

Published Papers

This special issue is now open for submission.
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