Recent Insights Into the Role of the Ubiquitin System in Cellular Protein Quality Control
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".
Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 19516
Special Issue Editors
Interests: ubiquitin-proteasome system; protein quality control; ERAD; yeast genetics & proteomics
Special Issues, Collections and Topics in MDPI journals
Interests: protein quality control; the ubiquitin-proteasome system; molecular chaperones; protein misfolding; genetic diseases
Special Issue Information
Dear Colleagues,
Post-translational modification by ubiquitin and ubiquitin-like (UBL) molecules plays a crucial role in multiple cellular pathways, including protein quality control (PQC). Unlike regulated ubiquitin conjugation, in which E3 ubiquitin-protein ligases recognize a small set of specific substrates, ubiquitylation in PQC must accommodate a broad range of different substrates and accordingly PQC ubiquitin ligases appear highly redundant. To perform their function, these ligases cooperate with molecular chaperones that keep misfolded substrates in a soluble form to enable their ubiquitylation, deliver substrates to the ubiquitylation machinery, and shuttle ubiquitylated proteins to the proteasome. When proteolysis fails, misfolded substrates are condensed into inclusion bodies, with the aid of designated chaperones, that may be targeted to autophagy. Failure of the PQC proteolytic system may have adverse consequences to cell viability, underlined by early- and late-onset proteopathies.
How the ubiquitin system is involved in PQC triage decisions is yet not fully understood, but clearly depends on key related factors, such as a protein’s folding state and aggregation propensity as well as availability of the PQC network and environmental conditions. This issue aims to introduce the state of the art in ubiquitin/UBL mediated PQC and highlight key finding, in order to stimulate the build-up of an open community with mutual research interests.
Prof. Dr. Tommer Ravid
Prof. Dr. Rasmus Hartmann-Petersen
Guest Editors
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Keywords
- ubiquitin
- proteolysis
- protein quality control
- molecular chaperones
- autophagy, inclusion bodies
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