Breast Cancer: Molecular Pathology, Drug Resistance and Novel Treatment Strategies

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 906

Special Issue Editor


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Guest Editor
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Winship Cancer Institute, Atlanta, GA 30322, USA
Interests: breast cancer; mechanism of drug resistance; novel therapeutic targets; precision oncology; novel treatment strategies
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Special Issue Information

Dear Colleagues,

Breast cancer is a highly heterogeneous disease, and despite significant therapeutic advancements, resistance to therapies and recurrence remain major clinical challenges. Understanding the molecular pathology of breast cancer is crucial for identifying mechanisms that drive drug resistance and disease progression. Emerging targeted therapies, immunotherapies, and novel drug combinations offer new hope, but their effectiveness is often limited by tumor heterogeneity and the complexity of the tumor microenvironment. This Special Issue will focus on the latest insights into breast cancer biology, explore mechanisms of resistance to current therapies, and highlight innovative treatment strategies aimed at improving patient outcomes.

Dr. Yesim Gokmen-Polar
Guest Editor

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Keywords

  • breast cancer
  • mechanism of resistance
  • targeted therapy resistance
  • ER+
  • HER2
  • TNBC
  • tumor microenvironment
  • recurrence
  • metastasis
  • tumor evasion

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Published Papers (1 paper)

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Research

20 pages, 16153 KB  
Article
STAMBP Accelerates Progression and Tamoxifen Resistance of Breast Cancer Through Deubiquitinating ERα
by Zhihuai Wang, Likai Gu, Mei Yang, Yi Zhou, Xihu Qin and Chen Xiong
Biomolecules 2025, 15(11), 1502; https://doi.org/10.3390/biom15111502 - 24 Oct 2025
Viewed by 295
Abstract
Breast cancer (BRCA) remains a global health burden, with endocrine-resistant ER-positive BRCA posing therapeutic challenges. This study investigates STAMBP’s role in breast cancer progression and evaluates its potential as a therapeutic target. Through siRNA library screening in ER-positive cell lines, we identified STAMBP [...] Read more.
Breast cancer (BRCA) remains a global health burden, with endocrine-resistant ER-positive BRCA posing therapeutic challenges. This study investigates STAMBP’s role in breast cancer progression and evaluates its potential as a therapeutic target. Through siRNA library screening in ER-positive cell lines, we identified STAMBP as a key regulator of ERα signaling and observed its upregulation in BRCA samples. (fold changes > 2, sample sizes = 30, p < 0.001), particularly in ER-positive subtypes. Prognostic analysis demonstrated that STAMBP overexpression correlates with poor clinical outcomes in ER-positive BRCA patients (p < 0.05). In vitro functional assays showed STAMBP promoted proliferation, metastasis, and epithelial–mesenchymal transition of ER-positive cells by regulating the activity of ERα signaling. Mechanistically, the deubiquitinase STAMBP directly reduces the K48-linked polyubiquitination levels of ERα, enhancing its protein stability and activating downstream oncogenic signaling. STAMBP knockdown restored tamoxifen sensitivity in endocrine-resistant BRCA cells by reducing ERα stability. This study has certain limitations, including the absence of pharmacological validation and reliance on small, single-center clinical cohorts, which should be addressed in future research to further substantiate the clinical relevance of targeting STAMBP in BRCA. Collectively, our findings identified STAMBP as a prognostic marker and demonstrated its dual role in driving ER-positive BRCA malignancy and mediating endocrine resistance. Targeting STAMBP may represent an innovative approach to improve endocrine therapeutic efficacy in ER-positive BRCA. Full article
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