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Special Issue "Molecular Mechanisms of Stress in Autoimmunity and Psychiatric Disorders"
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (25 September 2019).
Interests: autoimmunity; neuroimmunology; neuroinflammation; neurodegeneration; immune-based diagnosis and therapy
Interests: multiple sclerosis; neuroimmunology; neuroinflammatory disorders; immune regulation; immune–neural interaction; therapeutic mode-of-action and biological proof-of-principle studies; biomarker development
It has been well-established that stress can substantially affect the homeostatic regulation of the immune system via the activation of the hypothalamic–pituitary–adrenal (HPA) axis and the release of glucocorticoids (GCs) into the circulation. In turn, GCs act to regulate the activation, proliferation, and trafficking of leukocytes and are thus often used as immunosuppressors in the clinical treatment of inflammatory and autoimmune disorders.
In spite of the clear immunosuppressive potential of stress-induced GCs, chronic exposure to stress has also been linked with the relapse of autoimmune diseases (e.g., MS and psoriasis), increased pathogenicity of viral infections, or enhanced brain inflammation which may accelerate neurodegenerative and neuropsychiatric diseases. These diseases are all characterized by a pro-inflammatory immune response, implying that chronic stress exposure attenuates rather than enhances the immunosuppressive effects of GCs in various cell types. Reduced sensitivity to the immunosuppressive effects of GCs, referred to as glucocorticoid resistance, has been extensively described in patients with various inflammatory diseases where steroid treatment has failed. Whereas several molecular mechanisms underlying the dysfunction of glucocorticoid receptors (GRs) due to persistent inflammation or genetic defects have recently been described, further insights into these mechanisms may help to unveil regulatory roles of GCs in various tissues and cell compartments, to elucidate the etiology of diseases with strong inflammatory components, and to identify therapeutic strategies to overcome GC resistance in a variety of inflammatory diseases.
This Special issue of Biomolecules invites manuscripts and reviews which provide molecular and cellular mechanisms underlying the impact of chronic stress on autoimmune and psychiatric disorders.
Prof. Alon Monsonego
Prof. Amit Bar-Or
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- psychiatric disorders