Perspectives of Sphingolipids
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".
Deadline for manuscript submissions: closed (30 September 2020) | Viewed by 4891
Special Issue Editor
Interests: molecular neurobiology; molecular psychiatry; biomarkers for psychiatric diseases; alcohol dependence; depression; sphingolipid metabolism; psychoneuroendocrinology; assay development
Special Issue Information
Dear Colleagues,
Despite the exciting recent advances in techniques and the remarkable progress in the field, sphingolipids, termed after the mythological sphinx, still remain enigmatic because of their unprecedented complexity and their function both as membrane components and bioactive molecules. It is estimated that there are thousands of individual molecular sphingolipid species with heterogeneous cellular and subcellular localization, and a large variety of enzymes involved in their metabolism allow for a wide field of research and for possible applications. These compounds regulate critical cellular processes, such as cell proliferation, differentiation, migration, and cell death, and thus alterations can contribute to changed susceptibility, and to the development or maintenance of key human disorders like cancer, cardiovascular, neuropsychiatric, or inflammatory diseases.
The aim of this Special Issue on “Perspectives of Sphingolipids” is, on the one hand, to provide an overview of the potential for sphingolipids as biomarkers for the diagnosis, subtyping or classification, monitoring of therapy, or prognosis of various disorders. The identification of altered sphingolipid compositions and the enzymes involved in their pathways could also lead to the development of novel preventive and therapeutic approaches. However, the capacity of sphingolipids is not restricted to pathophysiology; these biomolecules could also serve other functions, including as probes or markers for physiological processes from bacteria to plants or biotechnology, or as distinct interacting partners. On the other hand, original articles are invited to contribute to these challenging areas, and to highlight discoveries on prospective applications of specific sphingolipid species.
I am looking forward to your contributions to advancing this fascinating field.
Dr. Christiane Mühle
Guest Editor
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Keywords
- sphingolipids
- lipidomics
- biomarker discovery
- bioactive lipids
- ceramide
- sphingomyelin
- therapeutic applications
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