p53 and Tumor Stroma
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 479
Special Issue Editors
Interests: regulation of wild-type and mutant p53; p53 DNA-binding cooperativity; cellular and organismal ageing; animal- and organoid-based models of hematopoietic and lung cancer
2. INSERM UMR1231, University of Burgundy Franche-Comté, 21078 Dijon, France; 3 Sirius University of Science and Technology, 354340 Sochi, Russia
Interests: anti-cancer therapy; DNA damage; cell death; senescence; p53 pathway; MAPK; phosphatases; immunotherapy
Special Issue Information
Dear Colleagues,
We are pleased to invite you for participation in the special issue “p53 and tumor stroma” which is being prepared for the journal Biomolecules
Solid tumors are highly dynamic and heterogeneous structures. Besides cancer cells, they contain extra-cellular matrix and many types of non-malignant cells such as fibroblasts, endothelial and immune cells, together composing the tumor stroma. Tumor stroma is not just a passive component which simply co-exists with the cancer cells. Upon tumor progression malignant cells strongly influence the surrounding micro-milieu and induce its reorganization. Altered microenvironment supports cancer cells, providing nutrition and protection from host immune system and therapeutic interventions. The multiple mechanisms that mediate interaction between cancer cells and tumor stroma are still incompletely understood, especially in the context of particular oncogenic mutations. One of the most frequent cancer-associated mutations detected in different types of solid tumors are mutations in the TP53 gene. This powerful tumor suppressor regulates a plethora of cellular processes, many of which raise barriers to tumorigenesis. In addition to cell-autonomous programs, p53 is involved in modulation of microenvironment from both sides – from tumor and stromal cells.
The aim of this special issue is to elucidate the activities employed by wild-type and mutant p53 in shaping tumor stroma and to highlight the role of these mechanisms for cancer development and therapy response. Original research manuscripts and reviews dealing with these aspects are very welcome.
Dr. Oleg Timofeev
Dr. Oleg N. Demidov
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Tumor microenvironment
- solid tumors
- response to therapy
- p53 secretome
- mutant p53
- therapy resistance
