Special Issue "Natural and Tailored Enzymes for Development of Smart Biotherapeutics"
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 428
Interests: molecular enzymology; enzyme engineering; enzyme derived prebiotics; polysaccharide-based biomaterials; therapeutic enzymes; enzyme biosensors; environmental biotechnology; enzyme immobilization
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Interests: enzyme biotechnology; molecular enzymology; enzyme engineering; therapeutic enzymes; protein downstream processing; enzyme biosensor; enzybiotics; Algae biotechnology; cosmetics; structure-based drug design; immobilized enzyme
Aims and scope: The prospect for the pharmaceutical use of enzymes has increased greatly in the last decades. A range of specific therapeutic and pharmaceutical functions is attributed to enzymes, including anticoagulant, oncolytic, thrombolytic, anti-inflammatory, and antimicrobial properties. In addition, years now enzymes have been studied, as targets in pharmaceutical setting and almost half of the drugs, currently in clinical practice, are enzyme inhibitors. The specificity, promiscuity, plasticity and druggability are the main features that make enzymes surpass the therapeutic ability of conventional drugs. Furthermore, these biomolecules are, by nature, endowed with stimulusresponsive behavior, while protein engineering and nanotechnology are intelligent tools, allowing their redesign and customization of their therapeutic and pharmaceutical potential. Studies that focus on kinetics and catalytic mechanism of an enzyme, can unveil key factors that can be exploited for drug design and development.
The exploitation of enzymes can direct the pharmaceutical industry toward the development of novel therapeutics for the treatment of chronic, curable andperhaps incurable diseases and further stimulate their use as drug targets. The purpose of this thematic issue is to call for all pharmaceutical and biotechnological studies on natural and engineered enzymes that work as biological therapeutics or drug targets. The subtopics that will be covered within this issue include: therapeutic enzymes; rational/combinatorial engineering; enzyme replacement therapy; enzymes as antidotes; enzymes in drug delivery; enzyme prodrug therapy; enzymobiotics; enzyme-instructed self-assembly; enzyme nanocomplexes; biomimetic and artificial enzymes and structurebased design of enzyme inhibitors.
Dr. Evangelia Chronopoulou
Dr. Nikolaos Labrou
Manuscript Submission Information
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- therapeutic enzymes
- rational/combinatorial enzyme engineering
- enzyme replacement therapy
- enzymes as antidotes
- enzymes in drug delivery
- enzyme prodrug therapy
- enzyme-instructed self-assembly
- enzyme nanocomplexes
- biomimetic and artificial enzymes
- structure-based design of enzyme inhibitors