MicroRNAs - Small Molecules with Great Potential in Tumorigenesis

Dear Colleagues,

MicroRNA RNAs represent a class of non-coding RNA transcripts that do not encode proteins, but they may play a role in the regulation of gene expression.

MicroRNAs can be differentially expressed in different tumor types, either benign or malignant, and they can also act as biomarkers. MicroRNAs can behave as oncogenes, favoring tumorigenesis. They can reduce the levels of proteins blocking proliferation and migration and activating apoptosis, whereas tumor-suppressive microRNAs can inhibit cancer development. Their inactivation in tumors is followed by the accumulation of proteins, stimulating proliferation and migration and decreasing apoptosis. Interestingly, microRNAs can also affect tumor progression by modulation of the development of new blood vessels. Due to the variety of microRNAs and their mechanisms of action, understanding how their altered expression contributes to cancer development and progression is a demanding task. Gaining insight into the mechanisms of microRNA regulation will increase opportunities for the discovery of novel therapeutic targets.

In this Special Issue, we will highlight implications of aberrant microRNAs in tumor development and progression. We welcome original articles and review articles that explore microRNA as regulators of signaling networks, cancer biomarkers or potential therapeutic targets.

Dr. Klaudia Skrzypek
Dr. Agnieszka Łoboda
Guest Editors

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