Special Issue "Alcohol and Molecules"

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editor

Dr. Faraz Bishehsari
E-Mail Website
Guest Editor
Department of Internal Medicine, Division of Digestive Diseases and Nutrition, Section of Gastroenterology, Rush Medical College, Chicago, IL 60612, USA
Interests: alcohol; organ damage; gastrointestinal cancers; microbiota; inflammation

Special Issue Information

Dear Colleagues,

Heavy alcohol consumption contributes to the increasing burden of chronic diseases worldwide. Alcohol is an established risk factor in a variety of pathologies from brain and liver damage to cancer at several anatomical sites. Alcohol’s effects are exerted via multiple known (direct DNA and cellular damages, oxidative stress, dysbiosis, hormonal and immune dysregulation) and as-yet unknown mechanisms. Identifying mechanisms that are involved in the alcohol-induced cellular and organ damages would provide targets for prevention and treatment.

For this Issue, studies that provide novel data or examine and review established mechanistics linking alcohol to organ damage will be considered. Possible differential effects of patterns of alcohol drinking at the molecular level are welcome.

Dr. Faraz Bishehsari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • alcohol
  • molecular damage
  • DNA damage
  • mitochondria
  • oxidative stress
  • hormonal dysregulation
  • barrier dysfunction
  • end-organ damage
  • cancers
  • microbiota
  • inflammation

Published Papers (1 paper)

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Research

Article
Impacts of Maternal Diet and Alcohol Consumption during Pregnancy on Maternal and Infant Gut Microbiota
Biomolecules 2021, 11(3), 369; https://doi.org/10.3390/biom11030369 - 01 Mar 2021
Viewed by 570
Abstract
(1) Background: Maternal diet and alcohol consumption can influence both maternal and infant’s gut microbiota. These relationships are still not examined in the Chinese population. The purpose of this study was to explore the effect of alcohol consumption and maternal diet during pregnancy [...] Read more.
(1) Background: Maternal diet and alcohol consumption can influence both maternal and infant’s gut microbiota. These relationships are still not examined in the Chinese population. The purpose of this study was to explore the effect of alcohol consumption and maternal diet during pregnancy on maternal and infant’s gut microbiota. (2) Methods: Twenty-nine mother-child dyads were enrolled in central China. Fecal samples of mothers during late pregnancy and of newborns within 48 h were collected. The V3–V4 regions of 16S rRNA sequences were analyzed. A self-administrated questionnaire about simple diet frequency in the past week was completed by mothers before childbirth. The demographic information was finished by mothers at 24 h after childbirth. (3) Results: Among these 29 mothers, 10 mothers reported alcohol consumption during pregnancy. The PCoA (β-diversity) showed significant difference in maternal gut microbiota between the alcohol consumption group vs. the non-alcohol consumption group (abund-Jaccard, r = 0.2, p = 0.006). The same phenomenon was observed in newborns (unweighted-UniFrac full tree, r = 0.174, p = 0.031). Maternal alcohol consumption frequency showed positive associations with maternal Phascolarctobacterium (p = 0.032) and Blautia (p = 0.019); maternal Faecalibacterium (p = 0.013) was negatively correlated with frequency of alcohol consumption. As for newborns, a positive relationship showed between Megamonas (p = 0.035) and newborns with maternal alcohol consumption. The diet was not associated with both maternal and infant’s gut microbiota. (4) Conclusions: Maternal alcohol consumption during pregnancy influenced the gut microbiota on both mothers and the newborns. Future research is needed to explore these relationships in a lager birth cohort. Understanding the long-term effect of alcohol consumption on maternal and newborns’ gut microbiota is needed. Full article
(This article belongs to the Special Issue Alcohol and Molecules)
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